[GERLACH, Valerie, L., MACDOUGALL, John, R., SMITHSON, Glennda, MILLET, Isabelle, STONE, David, GUNTHER, Erik, ELLERMAN, Karen, GROSSE, William, M., ALSOBROOK, John, P., II, LEPLEY, Denise, M., BURGESS, Catherine, E., PADIGARU, Muralidhara, KEKUDA, Ramesha, SPYTEK, Kimberly, A., LEACH, Martin, D., SHIMKETS, Richard, A.] 555 Long Wharf Drive 11th floor New Haven, CT 06511;18 Rock Pasture Road Branford, CT 06405;117 Russell Street Hamden, CT 06517;125 Michael Drive Guilford, CT 06435;74 Carrington Avenue Milford, CT 06460;223 Whitehorn Drive Guilford, CT 06437;34 Bryan Road Branford, CT 06405;87 Montoya Drive Branford, CT 06405;15 Rice Terrace Road Apartment C Branford, CT 06405;60 Lake Drive Madison, CT 06443;51 Church Street Branford, CT 06405;90 Carriage Hill Drive Wethersfield, CT 06109;71 Hampton Park Branford, CT 06405;1 Malthy Street Branford, CT 06405;28 Court St. #1 New Haven, CT 06511;131 Beechwood Drive Madison, CT 06433;191 Leete Street West Haven, CT 06516 Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antiboides, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[PADIGARU, Muralidhara, GROSSE, William, M., SZERKERES, Edward, D., CASMAN, Stacie, J., ALSOBROOK, John, P., III, BURGESS, Catherine, E., TAYLOR, Sarah, VERNET, Corine, A., M., BAUMGARTNER, Jason, C., TCHERNEV, Velizar, T., SPYTEK, Kimberly, A., LI, Li, SHENOY, Suresh, KEKUDA, Ramesha, GANGOLLI, Esha, A., STONE, David, J., SMITHSON, Glennda, MACDOUGALL, John, R.] 555 Long Wharf Drive 11th floor New Haven, CT 06511;98 Montoya Circle Branford, CT 06405;15 Rice Terrace Road, Apt. 2 Branford, CT 06405;130 Montoya Drive Branford, CT 06504;155 Knollwood Drive Wallingford, CT 06492;60 Lake Drive Madison, CT 06443;90 Carriage Hill Drive Wethersfield, CT 06109;29 Winthrop Road Cheshire, CT 06437;1739 Foxon Road, Box L North Branford, CT 06471;122 Derrwood Avenue Milford, CT 06460;1216 S.W. 2nd Avenue, Apt. 156 Gainesville, FL 32601;28 Court St. #1 New Haven, CT 06511;487 Oak Avenue #67 Cheshire, CT 06410;15 Millwood Drive Branford, CT 06405;1 Malthy Street Branford, CT 06405;383 Walden Green Branford, CT 06505;223 Whitethorn Drive Guilford, CT 06516;81 Main Street #32A Branford, CT 06504;343 Warpas Road Madison, CT 06443 Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[FERNANDES, Elma, VERNET, Corine, A., M., MISHNU, Vishnu, S., LEACH, Martin, D., SHIMKETS, Richard, A., ZERHUSEN, Bryan, D., KEKUDA, Ramesha] 555 Long Wharf Drive 11th floor New Haven, CT 06511;77 Florence Road, #2 Branford, CT 06405;1739 Foxon Road, Box L North Branford, CT 06471;309 East Main Street #306 Branford, CT 06405;884 School Street Webster, MA 01570;191 Leete Street West Haven, CT 06516;485 Jefferson Road, Apt. 2-10 Branford, CT 06405;1 Malthy Street Branford, CT 06405 The present invention provides ORFX, polynucleotides and polypeptides and antibodies that immunospecifically bind to ORFX. The invention additionally provides methods in which the ORFX polypeptides/polynucleotides and antibodies are used in detection and treatment of a broad range of pathological states.

[CASMAN, Stacie, J., EDINGER, Shlomit, R., ELLERMAN, Karen, SMITHSON, Glennda, KEKUDA, Ramesh, MURALIDHARA, Padigaru] 555 Long Wharf Drive 11th Floor New Haven, CT 06511;17 Peck Street North Haven, CT 06473;766 Edgewood Avenue New Haven, CT 06515;87 Montoya Drive Branford, CT 06405;125 Michael Drive Guilford, CT 06435;1 Malthy Street Branford, CT 06405;Apartment 6E 1579 Rhinelander Ave. Bronx, NY 10561 Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.