[DAVIS, C., Geoffrey, BLACHER, Russell, W., CORVALAN, Jose, R., CULWELL, Alan, R., GREEN, Larry, L., HALES, Joanna, HAVRILLA, Nancy, IVANOV, Vladimir, E., LIPANI, John, A., LIU, Qiang, WEBER, Richard, F., YANG, Xiao-Dong] 7601 Dumbarton Circle Fremont, CA 94555;1132 Vancouver Avenue Burlingame, CA 94010;16800 Columbia Drive Castro Valley, CA 94552;125 Williams lane Foster City, CA 94404;290A Hemlock Avenue Carlsbad, CA 92008;Apartment 12 70 Crestline Drive San Francisco, CA 94131;5180 Selma Avenue Fremont, CA 94536;6 Marlin Cove Oakland, CA 94618;4275 Tanager Common Fremont, CA 94555;2263 Latour Avenue Livermore, CA 94550;55 Williams Lane Foster City, CA 94404;2537 Pacheco Street San Francisco, CA 94116;2833 Bryant Street Palo Alto, CA 94306 In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.