5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637 This disclosure relates to compositions and methods for treating lung disorders, including, for example, pulmonary fibrosis, and other fibrotic disorders. Thioredoxin domain-containing 5 (TXNDC5) is significantly increased in fibrotic lungs from human PF patients. Therefore, a targeted nanoparticle comprising an inhibitor of TXNDC5 was developed, which may have potential to treat pulmonary fibrosis.

5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University Of Chicago5801 S. Ellis Ave.Chicago, IL 60637 This disclosure relates to compositions and methods for treating hypothyroidism. This disclosure relates to compositions and methods for treating hypothyroidism.

5801 S. Ellis Ave.Chicago, IL 60637;c/o The Universtiy of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The Univesity of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5800 S. Ellis AvenueChicago, Illinois 60637;c/o The University of Chicago5800 S. Ellis AvenueChicago, Illinois 60637 This disclosure relates to compositions and methods for treating arterial disease, including, for example, atherosclerosis, peripheral artery disease, ischemic stroke, and stenosis. This disclosure relates to compositions and methods for treating arterial disease, including, for example, atherosclerosis, peripheral artery disease, ischemic stroke, and stenosis.

5801 S. Ellis Ave.Chicago, IL 60637;c/o The University Of Chicago5801 S. Ellis Ave.Chicago, IL 60637;c/o The University of Chicago5801S. Ellis Ave.Chicago, Illinois 60637;c/o The University of Chicago5801S. Ellis Ave.Chicago, Illinois 60637 This disclosure relates to compositions and methods for treating lung disorders, including, for example, Acute Respiratory Distress Syndrome (ARDS), Ventilator-Induced Lung Injury (VILI), Acute lung injury (ALI), and other acute and chronic lung disorders. This disclosure relates to compositions and methods for treating lung disorders, including, for example, Acute Respiratory Distress Syndrome (ARDS), Ventilator-Induced Lung Injury (VILI), Acute lung injury (ALI), and other acute and chronic lung disorders.

[SCHNEEWIND, Olaf, CHENG, Alice, G., MISSIAKAS, Dominique, M., KIM, Hwan, Keun, KIM, Hye-young] 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;C/o University Of Chicago 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;906 E 53rd St., Apt 1 Chicago, IL 60615; The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve a non-toxigenic Protein A (SpA) variant. In some embodiments, the methods and compositions involve SdrD, ClfA, and/or FnbpB polypeptides.

[SCHNEEWIND, Olaf, MISSIAKIS, Dominique, MCADOW, Molly, KIM, Hwan, Keun] 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;;906 E. 53rd St., Apt. 1 Chicago, IL 60615 Certain embodiments are directed to methods of inhibiting Staphylococcal infection comprising administering effective amounts of a ClfA inhibitor and a thrombin inhibitor to a patient.

[SCHNEEWIND, Olaf, MISSIAKAS, Dominique, M., KIM, Hwan, Keun, EMOLO, Carla, DEDENT, Andrea] 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;906 East 53rd Apt. #1 Chicago, IL 60615;; Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Staphylococcal protein A (SpA).

[SCHNEEWIND, Olaf, KIM, Hye-Young, MISSIAKAS, Dominique, M., KIM, Hwan Keun] 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;10151 Arrow Route Unit #71 Rancho Cucamonga, CA 91730;5628 S. Blackstone Ave. Chicago, IL 60637;906 E 53rd St., Apt. 1 Chicago, IL 60615 The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. In certain embodiments, the methods and compositions involve attenuated S. aureus strains having deletions in their genome, such as in the srtA and saeR regions.

[SCHNEEWIND, Olaf, MISSIAKAS, Dominique, M., WANG, Yating] 5801 S. Ellis Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637;5628 S. Blackstone Ave. Chicago, IL 60637; Production of protein conjugate vaccines by use of transpeptidase enzymes, such as sortase enzymes. For example, homogenous immunoconjugates (e.g., a population of molecules having the same structure) formed by conjugating an antigenic polypeptide and a bacterial capsule component are provided. In certain aspects, methods for generating an immune response to B. anthracis by use of protective antigen-PDGA immunoconjugates are provided.

[GUYOT-SIONNEST, Philippe, KEULEYAN, Sean, E., LHUILLIER, Emmanuel] 5801 South Ellis Avenue Chicago, IL 60637;5528 S. Woodlawn Ave. Chicago, IL 60637;5018 S. Blackstone Ave., Apt. 103 Chicago, IL 60615;5316 S. Dorchester Ave. Chicago, IL 60615 Nanoparticles, methods of manufacture, devices comprising the nanoparticles, methods of their manufacture, and methods of their use are provided herein. The nanoparticles and devices having photoabsorptions in the range of 1.7 μm to 12 μm and can be used as photoconductors, photodiodes, phototransistors, charge-coupled devices (CCD), luminescent probes, lasers, thermal imagers, night-vision systems, and/or photodetectors.