[CHEN, Li, FENG, Lichun, FENG, Song, GAO, Lu, GUO, Tao, HUANG, Mengwei, LIANG, Chungen, LIU, Yongfu, WANG, Lisha, WONG, Jason Christopher, WU, Jim Zhen, WU, Xihan, YUN, Hongying, ZHENG, Xiufang] Grenzacherstrasse 124 CH-4070 Basel;No.2 Chexin Highway, Building C-40, Songjiang, Shanghai 201a Songjiang, Shanghai, 201612;No. 181, Lane 555, Jinping Road Shanghai, 200240;237 Bohua Road, Building 47, Room 602# Pudong, Shanghai, 201204;715 Wanxia Road, #161-101 Pudong, Shanghai, 201202;2131 Jingao Road, #47-601 Shanghai, 201206;Room 901, Building 2, Lane 825, Chenhui Road Pudong, Shanghai, 201203;Lane 825 Chenhui Road, Building 5, Room 1202 Pudong, Shanghai, 201203;Room 303, No. 5, Lane 652 Kongjiang Road Yangpu District, Shanghai, 200093;Thannerstrasse 80 1st Floor CH-4054 Basel;14 Moonbeam Drive Mountain View, CA 94043;Lane 39 Yinxiao Road, No. 6, Room 1601 Pudong, Shanghai, 201204;Apartment 2-1101, Building 12, Jinmao Garden Nanjing, 210037;802 Yinghua Road, Bldg. 1, Aprt. 202 Pudong, Shanghai 201204;Room 504, No. 2, Lane 1728 Chengshan Road Shanghai, 200128 A compound of formula (I), as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in description and in claims, can be used as a medicament for the treatment of respiratory syncytial virus.

[NAN, Fajun, YU, Lifang, ZHANG, Mei, CHEN, Li, HUANG, Mengwei, FENG, Lichun, LI, Jia, PANG, Tao] Grenzacherstrasse 124 CH-4070 Basel;Room 701, No. 21, Lane 825, Chenhui Road, Pudong Shanghai 201203;189 Guoshoujing Road, Pudong Shanghai 201203;Room 404, No. 39, Lane 126, Lianxi Road, Pudong Shanghai 201204;Dongjiao State Guest Hotel A18, No. 1800 Jinke Road Shanghai 201203;Room 901, Building 2, Lane 825, Chenhui Road, Pudong Shanghai 201203;No. 181, Lane 555, Jinping Road Shanghai 200240;No. 567 Jing An East Road Shanghai 201204;1001 Rockville Pike, Apt. 1808, Rockville Maryland 20852 A compound of formula (I), the pharmaceutically acceptable salt, the pharmaceutical composition, the preparation method and the use thereof.

[CHEN, Li, FENG, Lichun, HUANG, Mengwei, LI, Jia, NAN, Fajun, PANG, Tao, YU, Lifang, ZHANG, Mei] Grenzacherstrasse 124 CH-4070 Basel;Dongjiao State Guest Hotel A18 No. 1800 Jinke Road Shanghai, 201203;No. 181, Lane 555, Jinping Road Shanghai, 200240;Room 901, Building 2, Lane 825 Chenhui Road Pudong, Shanghai, 201203;No. 567 Jing An East Road Pudong, Shanghai, 201204;Room 701, No. 21, Lane 825, Chenhui Road Pudong, Shanghai, 201203;1001 Rockville Pike, Apt. 1808 Rockville, Maryland 20852;833 S Wood St, Rm 505 Chicago, Illinois 60612;Room 404, No. 39, Lane 126, Lianxi Road Pudong, Shanghai, 201204 A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.

[CHEN, Yuanwei, FENG, Yan, XU, Baihua, LV, Binhua, SEED, Brian, HADD, Michael J., CHENG, Huawei, SHENG, Zelin, XU, Min, WANG, Congna, DU, Jiyan, ZHANG, Lili, XU, Ge, WU, Yuelin] 550 Del Rey Ave. Sunnyvale, California 94085-3528;15 Blue Ridge Lane North Haven, Connecticut 06473;850 Elizabeth Street, 2nd Floor Ridgefield, New Jersey 07657;Room 502, No. 9 Building 1152 East Huaxia Road Pudong New Area Shanghai 201200;Room 1303, Building 42 825 Chenhui Rd. 2nd Zhangjiang Tomson Garden Pudong New District Shanghai 201203;2 Hawthorne Place, Apt. 2J Boston Massachusetts 02114;2977 Bayside Lane San Diego, California 92109;Room 901, #4 2000 DongLu Road Pudong New District Shanghai 201206;82 Franklin Drive Belle Mead, New Jersey 08502;Room 902, No. 14, 158 Nong Baocheng Rd. Minhang Shanghai 201206;Room 301, Building 3 785 Xinde Rd. Chuansha Town Pudong New District Shanghai 201203;Room 102, Building 49 420 Qinghe Rd. Jiading District Shanghai 201800;Room 602, Building 33 1880 Longyang Rd. Wangbang City Garden Pudong New District Shanghai 201204;Room 301, Building 36 1155 Guanglan Rd. Liuming Garden Pudong New District Shanghai 201203;Room 502, 2169 South Pudong Rd. Pudong New District Shanghai 200127 Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

[CHEN, Li, FENG, Lichun, HUANG, Mengwei, LIU, Yongfu, WU, Guolong, WU, Jim, Zhen, ZHOU, Mingwei] Grenzacherstrasse 124 CH-4070 Basel;No.2 Chexin Highway, Building C-40, Songjiang Shanghai, 201612;No. 181, Lane 555, Jinping Road Shanghai, 200240;Room 901, Building 2, Lane 825, Chenhui Road Pudong, Shanghai, 201203;Room 502, No.1, Building 4, 171 Lane, Jianzhong Road Shanghai, 201203;Room 601, No. 15, Lane 329, Fang Hua Road, Pudong New Area Shanghai, 201204;Room 1601, No. 6, Lane 39, Yinxiao Road Pudong New District, Shanghai, 201204;Room 1505, Lane 3046, Chuan Bei Road Shanghai, 101210 A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.

[CHEN, Yuanwei, CHENG, Huawei, LI, Shengbin, WU, Yuelin, FENG, Yan, LV, Binhua, XU, Baihua, SEED, Brian, HADD, Michael J., SONG, Yanli, DU, Jiyan, WANG, Congna, ROBERGE, Jacques Y.] 550 Del Rey Ave. Sunnyvale, California 94085-3528;15 Blue Ridge Lane North Haven, Connecticut 06473;Room 901, #4 2000 DongLu Road Pudong New District Shanghai 201206;Room 303, Building 28 2000 Lingshan Rd. Pudong New District Shanghai 200136;Room 502, 2169 South Pudong Rd. Pudong New District Shanghai 200127;850 Elizabeth Street, 2nd Floor Ridgefield, New Jersey 07657;Room 1303, Building 42 825 Chenhui Rd. 2nd Zhangjiang Tomson Garden Pudong New District Shanghai 201203;Room 502, Building 9 1152 East Huaxia Rd. Pudong New Area Shanghai 201200;2 Hawthorne Place, Apt. 2J Boston, Massachusetts 02114;2977 Bayside Lane San Diego, California 92109;Room 401, Building 11 1166 Guanglan Rd. Pudong New District Shanghai 201210;Room 102, Building 49 420 Qinghe Rd. Jiading District Shanghai 201800;Room 301, Building 3 785 Xinde Rd. Chuansha Town Pudong New District Shanghai, Shanghai 201203;T9-9C, Seasons Parkview 1983 Hua Mun Rd. Shanghai 201204 Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by SGLT inhibition.

[CHEN, Li, FENG, Lichun, HE, Yun, HUANG, Mengwei, LIU, Yongfu, YUN, Hongying, ZHOU, Mingwei] Grenzacherstrasse 124 CH-4070 Basel;Dongjiao State Guest Hotel A 18, No. 1800 Jinke Road Shanghai, 201203;555 Jin Ping Road, No. 181, Minhang Shanghai, 200240;1298 Kangqiao Road, #99, Nanhui District Shanghai, 201315;Room 901, Building 2, Lane 825, Chenhui Road Pudong, Shanghai, 201203;Room 502, No.1, Building 4, 171 Lane, Jianzhong Road Shanghai, 201203;802 Yinghua Road, Bldg. 1, Aprt. 202 Pudong, Shanghai, 201204;Room 1505, Lane 3046, Chuan Bei Road Shanghai, 101210 A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as AMPK activators.

[FENG, Lichun, HUANG, Mengwei, LIU, Yongfu, WU, Guolong, ZHOU, Mingwei] Grenzacherstrasse 124 CH-4070 Basel;555 Jin Ping Road, No. 181, Minhang Shanghai, 200240;Room 901, Building 2, Lane 825, Chenhui Road Pudong, Shanghai, 201203;Room 502, No. 1, Building 4, 171 Lane, Jianzhong Road Shanghai, 201203;Room 601, No. 15, Lane 329, Fang Hua Road, Pudong New Area Shanghai, 201204;Room 1505, Lane 3046, Chuan Bei Road Shanghai, 101210 A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.

[FENG, Lichun, HUANG, Mengwei, LIU, Yongfu, WU, Guolong, YAN, Shixiang, YUN, Hongying, ZHOU, Mingwei] Grenzacherstrasse 124 CH-4070 Basel;555 Jin Ping Road, No. 181, Minhang Shanghai, 200240;Lane 825 Chenhui Road, Building 2, Room 901, Pudong Shanghai, 201203;Room 303, No. 5, Lane 652 Kongjiang Road Yangpu District Shanghai, 200093;Room 601, No. 15, Lane 329, Fang Hua Road, Pudong New Area Shanghai, 201204;396 Ling Zhao Rd, No. 4, Rm. 402 Shanghai, 200124;802 Yinghua Rd. Bldg 1, Apt# 202, Pudong Shanghai, 201204;Room 1505, Lane 3046, Chuan Bei Road Shanghai, 101210 A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the significance given in claim 1, can be used as AMPK modulators for treating obesity, hyperglycemia or type 2 diabetes.

[CHEN, Li, FENG, Lichun, HE, Yun, HUANG, Mengwei, YUN, Hongying] Grenzacherstrasse 124 CH-4070 Basel;No.2 Chexin Highway Building C-40, Songjiang Shanghai 201612;No. 181, Lane 555, Jinping Road Shanghai 200240;1298 Kangqiao Road, #99, Nanhui District Shanghai 201315;Room 901, Building 2, Lane 825 Chenhui Road Pudong, Shanghai 201203;802 Yinghua Road, Bldg. 1, Aprt. 202 Pudong, Shanghai 201204 A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1, can be used as a modulator of AMPK.