agt:(LINDA LIU & PARTNERS 北京林达刘知识产权代理事务所(普通合伙))
ANTI-COUNTERFEITING REFLECTIVE SHEET AND PREPARATION METHOD THEREFOR
PCT/CN2023/139930
[JIANG, Jihui 蒋纪辉, HAN, Jianjun 韩剑钧, XIAO, Yuetang 肖岳堂, CHEN, Yan 陈燕]
{No. 99 Hongda Road, Qiaonan Block, Xiaoshan Economic & Technology Development Zone 中国浙江省杭州市萧山经济技术开发区桥南区块鸿达路99号, Zhejiang 311231Hangzhou, Zhejiang 311231;CN CN(CN)(CN)}
An anti-counterfeiting reflective sheet and a preparation method therefor. The anti-counterfeiting reflective sheet is provided with a glass microbead (3) encapsulated structure, and comprises a specular reflective layer (5), some metal (10) of the specular reflective layer (5) being removed by electromagnetic radiation. The anti-counterfeiting reflective sheet may provide both RFID signal transmission and retroreflective performance.
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DOUBLE-STRANDED RIBONUCLEIC ACID FOR INHIBITING ANGPTL3 GENE EXPRESSION, AND MODIFIER, CONJUGATE, AND USE THEREOF
PCT/CN2023/108634
[WANG, Shucheng 王书成, HUANG, He 黄河, WANG, Yan 王岩, LIN, Guoliang 林国良, CHAN, Yunxia 产运霞, GENG, Yuxian 耿玉先, WANG, Xiaojun 汪小君, RONG, Mei 荣梅]
NO.8, Guangyuan East Street, Tongzhou Industrial Development Zone 中国北京市通州区通州工业开发区广源东街8号, Beijing 101113Tongzhou District, Beijing 101113
The present disclosure relates to a double-stranded ribonucleic acid for inhibiting ANGPTL3 gene expression, and a modifier, a conjugate, and use thereof. Specifically, the present disclosure relates to a double-stranded ribonucleic acid, a double-stranded ribonucleic acid modifier, a double-stranded ribonucleic acid conjugate, a pharmaceutical composition and use for inhibiting ANGPTL3 gene expression, and a method for inhibiting intracellular ANGPTL3 gene expression. The double-stranded ribonucleic acid provided in the present disclosure can bind in cells to form an RNA-induced silencing complex (RISC), which cleaves the mRNA transcribed by the ANGPTL3 gene, efficiently and specifically inhibiting the expression of the ANGPTL3 gene. The double-stranded ribonucleic acid is used for treating diseases associated with ANGPTL3 gene-mediated metabolic disorders, and has important application prospects in clinical disease treatment.
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THERMAL-FIELD GENERATION APPARATUS CAPABLE OF REALIZING AUTOMATIC TEMPERATURE CONTROL, AND MANUFACTURING METHOD THEREFOR
PCT/CN2022/109479
[SHAO, Yue 邵玥, ZHENG, Yifan 郑伊凡]
No. 1 Tsinghua Yuan, Haidian District 中国北京市海淀区清华园1号, Beijing 100084Beijing 100084
Provided in the present application are a thermal-field generation apparatus capable of realizing automatic temperature control, and a manufacturing method therefor. The thermal-field generation apparatus capable of realizing automatic temperature control comprises a plurality of automatic temperature control elements (2), which form an array, wherein each automatic temperature control element (2) comprises an automatic-temperature-control element loading structure (21) and an automatic-temperature-control heat source (22); and the automatic-temperature-control heat source (22) is disposed on the automatic-temperature-control element loading structure (21), and the automatic-temperature-control heat source (22) contains magnetic nanoparticles and hydrogel, which magnetic nanoparticles are dispersed in the hydrogel, and can generate heat in an alternating magnetic field. Provided in the present application are a thermal-field generation apparatus capable of realizing automatic temperature control, and a manufacturing method therefor. The thermal-field generation apparatus capable of realizing automatic temperature control comprises a plurality of automatic temperature control elements (2), which form an array, wherein each automatic temperature control element (2) comprises an automatic-temperature-control element loading structure (21) and an automatic-temperature-control heat source (22); and the automatic-temperature-control heat source (22) is disposed on the automatic-temperature-control element loading structure (21), and the automatic-temperature-control heat source (22) contains magnetic nanoparticles and hydrogel, which magnetic nanoparticles are dispersed in the hydrogel, and can generate heat in an alternating magnetic field.
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AUTOMATIC TEMPERATURE CONTROL DEVICE INTEGRATING MAGNETOCALORIC AND LIQUID COOLING FUNCTIONS, AND MANUFACTURING METHOD THEREFOR
PCT/CN2022/109482
[SHAO, Yue 邵玥, ZHENG, Yifan 郑伊凡]
No. 1 Tsinghua Yuan, Haidian District 中国北京市海淀区清华园1号, Beijing 100084Beijing 100084
The present application provides an automatic temperature control device integrating magnetocaloric and liquid cooling functions, and a manufacturing method therefor. The automatic temperature control device integrating magnetocaloric and liquid cooling functions comprises: a plurality of automatic temperature control elements (2), wherein the automatic temperature control elements (2) comprise automatic temperature control heat sources (22), the automatic temperature control heat sources (22) comprise magnetic nanoparticles and hydrogels, the magnetic nanoparticles are dispersed in the hydrogels, and the magnetic nanoparticles can generate heat in an alternating magnetic field; and a thermal field base plate (1), wherein the thermal field base plate (1) is provided with a plurality of mounting slots (11), the automatic temperature control elements (2) are arranged in the mounting slots (11), a liquid cooling channel (12) is arranged around the mounting slots (11), and the liquid cooling channel (12) is used for allowing for passage of a cooling medium.
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PHOSPHORUS PENTAFLUORIDE GAS GENERATOR AND PHOSPHORUS PENTAFLUORIDE GAS GENERATION METHOD
PCT/CN2023/079338
[LI, Zhenxing 李振星, XU, Sheng 许晟, CHEN, Hongwei 陈宏伟, NISHIMATSU, Koei 西松江英]
No. 1 Sensong Road, Rugao Port Area, Changjiang District, Rugao City 中国江苏省南通市如皋市长江镇(如皋港区)森松路1号, Jiangsu 226532Nantong, Jiangsu 226532
The present invention provides a phosphorus pentafluoride gas generator and a phosphorus pentafluoride gas generation method. Two liquid material feeders used for feeding liquid hydrogen fluoride into a generator cylinder are arranged on an upper cylinder of the generator cylinder. A lower cylinder of the generator cylinder is provided with a liquid hydrogen fluoride permeation jacket arranged along the inner wall of the lower cylinder. The liquid hydrogen fluoride permeation jacket is provided with an isolation filter plate used for bearing and contacting a phosphorus pentachloride solid material in the generator cylinder. The liquid hydrogen fluoride supplied by a liquid hydrogen fluoride supply device permeates into the generator cylinder through the isolation filter plate and reacts with the phosphorus pentachloride solid material. By using the phosphorus pentafluoride gas generator and the phosphorus pentafluoride gas generation method, liquid hydrogen fluoride participating in reaction can fully contact and react with a phosphorus pentachloride solid material of a reaction object, so that the generation efficiency of a phosphorus pentafluoride gas is improved.
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LABELING METHOD AND APPARATUS, ELECTRONIC DEVICE, AND STORAGE MEDIUM
PCT/CN2021/087285
[LUO, Zefeng 罗泽丰, ZHONG, Huaping 钟华平, HE, Conghui 何聪辉]
Room 201, Building A, No. 1, Qianwan Road, Qianhai Shenzhen-Hongkong Modern Service Industry Cooperation Zone 中国广东省深圳市前海深港合作区前湾一路1号A栋201室, Guangdong 518000Shenzhen, Guangdong 518000
Provided are a labeling method and apparatus, electronic device, and storage medium, said method comprising: receiving a first operation to label a target image (S11), said first label operation being used for drawing a first drawn graphic indicating a first image region in said target image; if a second drawn graphic in said target image overlaps at least partially with said first drawn graphic, then adjusting the first drawn graphic to obtain a labeling result corresponding to the first label operation (S12).
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OIL COLLECTING BUSHING FOR BEARING AND TRANSMISSION
PCT/CN2020/122429
Industriestrasse 1-3 德国黑措根奥拉赫工业街1-3, Herzogenaurach 9107491074 Herzogenaurach;Room 502, No. 3, Lane 55, Huazhan Road, Xuhui District 中国上海市徐汇区华展路55弄3号502室, Shanghai 200231Shanghai 200231
An oil collecting bushing for a bearing. The bushing is used for guiding lubricating oil into a roller path (2S) of a bearing (2), and comprises a cylindrical bushing main body (11) and a plurality of oil claws (12). An oil collecting groove for collecting the lubricating oil is formed on an inner circumferential part of the bushing main body (11), and the bushing main body (11) is provided with a plurality of openings (11h) which penetrate the bushing main body (11) and which are in communication with the oil collecting groove. The plurality of oil claws (12) are arranged at the parts of the bushing main body (11) where the openings (11h) are formed, and each oil claw (12) is formed so as to warp radially outwards from the bushing main body (11). Therefore, under the centrifugal force generated during the rotation of an oil collecting bushing (1), the lubricating oil from the oil collecting groove can be guided into the roller path (2S) by the oil claws (12) via the corresponding openings (11h). With the oil collecting bushing, the bearing is not only effectively lubricated, but is also cooled down. Further provided is a transmission comprising the oil collecting bushing. An oil collecting bushing for a bearing. The bushing is used for guiding lubricating oil into a roller path (2S) of a bearing (2), and comprises a cylindrical bushing main body (11) and a plurality of oil claws (12). An oil collecting groove for collecting the lubricating oil is formed on an inner circumferential part of the bushing main body (11), and the bushing main body (11) is provided with a plurality of openings (11h) which penetrate the bushing main body (11) and which are in communication with the oil collecting groove. The plurality of oil claws (12) are arranged at the parts of the bushing main body (11) where the openings (11h) are formed, and each oil claw (12) is formed so as to warp radially outwards from the bushing main body (11). Therefore, under the centrifugal force generated during the rotation of an oil collecting bushing (1), the lubricating oil from the oil collecting groove can be guided into the roller path (2S) by the oil claws (12) via the corresponding openings (11h). With the oil collecting bushing, the bearing is not only effectively lubricated, but is also cooled down. Further provided is a transmission comprising the oil collecting bushing.
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OCCUPANT DETECTION METHOD AND APPARATUS IN VEHICLE CABIN, ELECTRONIC DEVICE, AND STORAGE MEDIUM
PCT/CN2021/078692
[QI, Kaiyue 祁凯悦, WU, Jun 伍俊, FAN, Yiqing 范亦卿, TAO, Ying 陶莹, XU, Liang 许亮]
Room 01, 2nd Floor, No. 29, 30, Lane 1775, Qiushan Road, Mucheng Town 中国上海市自由贸易试验区临港新片区泥城镇秋山路1775弄29、30号2楼01室, Shanghai 200232Lingang New Area, Pilot Free Trade ZoneShanghai 200232
An occupant detection method and apparatus in a vehicle cabin, an electronic device, and a storage medium. The method comprises: obtaining an image in the vehicle cabin (S11); on the basis of the image, detecting a riding area of a target occupant belonging to a preset population in the vehicle cabin (S12); and in response to detecting that the riding area of the target occupant matches a non-permitted riding area of the preset population, generating reminder information (S13). An occupant d
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POLYNUCLEOTIDE HAVING PROMOTER ACTIVITY AND APPLICATION OF POLYNUCLEOTIDE IN PRODUCING AMINO ACID
PCT/CN2021/106501
[ZHENG, Ping 郑平, LIU, Jiao 刘娇, SUN, Jibin 孙际宾, ZHOU, Wenjuan 周文娟, SHI, Tuo 石拓, GUO, Xuan 郭轩, MA, Yanhe 马延和]
32 West 7th Avenue, Tianjin Airport Economic Area 中国天津市空港经济区西七道32号, Tianjin 300308Tianjin 300308
Provided are a polynucleotide having promoter activity and an application of the polynucleotide in producing an amino acid. Also disclosed are a transcription expression cassette, a recombinant expression vector, and a recombinant host cell which contain the polynucleotide, and a method for enhancing expression of a target gene, a method for preparing a protein, and a method for producing an amino acid. The polynucleotide having the promoter activity is a mutant of a polynucleotide having the sequence as shown in SEQ ID NO: 9. Compared with the polynucleotide having the sequence as shown in SEQ ID NO: 9, the promoter activity of the mutant is significantly enhanced, thereby promoting the stable and efficient expression of the target gene.
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3,4-DIHYDROISOQUINOLINE COMPOUND AND USE THEREOF
PCT/CN2021/097746
[ZHAO, Chuanwu 赵传武, ZHANG, Yan 张颜, YANG, Jinlu 杨金路, ZHANG, Li 张莉, ZHANG, Xuejiao 张雪娇, CUI, Shuxiang 崔淑香, GUO, Qian 郭谦]
No.226, Huanghe Street, High-Tech Development Zone 中国河北省石家庄市高新技术产业开发区黄河大道226号, Hebei 050035Shijiazhuang, Hebei 050035
Provided in the present invention are a compound as represented by formula (I), or a pharmaceutically acceptable salt, a tautomer, a geometrical isomer, an optical isomer, a solvate or an isotopic derivative thereof, and the use thereof. The compound of the present invention has a significant inhibitory activity on PRMT5, has a significant inhibitory effect on tumor cells and in vivo tumor models, also has a good administration performance, and has clinical application potential for preventing and/or treating diseases which are at least partially mediated by PRMT5.
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