[ANDREWS III CLARENCE W, DAVIS-WARD RONDA G, EMMITTE KYLE A, KUNTZ KEVIN W, MOOK JR ROBERT A, VEAL JAMES M, CHEUNG MUI, DREWRY DAVID H, HUBBARD ROBERT D, LINN JAMES A, SMITH GARY K] US

[ANDREWS III CLARENCE W, LINN JAMES ANDREW, MOOK ROBERT ANTHONY JR, VEAL JAMES MARVIN, SMITH GARY KEITH, CHEUNG MUI, DAVIS-WARD RONDA G, DREWRY DAVID HAROLD, KUNTZ KEVIN W, HUBBARD ROBERT DALE, EMMITTE KYLE ALLEN] US The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

[ANDREWS, III, Clarence, W, CHEUNG, Mui, DAVIS-WARD, Ronda, G, DREWRY, David, Harold, EMMITTE, Kyle, Allen, HUBBARD, Robert, Dale, KUNTZ, Kevin, W, LINN, James, Andrew, MOOK, Robert, Anthony Jr., SMITH, Gary, Keith, VEAL, James, Marvin] One Franklin Plaza Philadelphia, PA 19101;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;GlaxoSmithKline Five Moore Drive PO Box 13398 Research Triangle Park, NC 27709;8916 Weaver Crossing Road Apex, NC 27502 The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

[ANDREWS III CLARENCE W, CHEUNG MUI, DAVIS-WARD RONDA G, DREWRY DAVID HAROLD, EMMITTE KYLE ALLEN, HUBBARD ROBERT DALE, KUNTZ KEVIN W, LINN JAMES ANDREW, MOOK ROBERT ANTHONY, SMITH GARY KEITH, VEAL JAMES MARVIN] US

[MOOK ROBERT ANTHONY, SMITH GARY KEITH, VEAL JAMES MARVIN, ANDREWS III CLARENCE W, CHEUNG MUI, DAVIS-WARD RONDA G, DREWRY DAVID HAROLD, EMMITTE KYLE ALLEN, HUBBARD ROBERT DALE, KUNTZ KEVIN W, LINN JAMES ANDREW]

[ANDREWS CLARENCE W III, CHEUNG MUI, DAVIS-WARD RONDA G, DREWRY DAVID HAROLD, EMMITTE KYLE ALLEN, HUBBARD ROBERT DALE, KUNTZ KEVIN W, LINN JAMES ANDREW, MOOK ROBERT ANTHONY JR, SMITH GARY KEITH, VEAL JAMES MARVIN] US

[KUNTZ KEVIN W, DREWRY DAVID HAROLD, VEAL JAMES MARVIN, DAVIS-WARD RONDA G, EMMITTE KYLE ALLEN, CHEUNG MUI, SMITH GARY KEITH, LINN JAMES ANDREW, HUBBARD ROBERT DALE, ANDREWS III CLARENCE W, MOOK ROBERT ANTHONY JR] US

[SHERRILL, Ronald George,Glaxo Wellcome Inc., HALE, Michael, R., SPALTENSTEIN, Andrew,Glaxo Wellcome Inc., FURFINE, Eric Steven,Glaxo Wellcome Inc., ANDREWS, Clarence W., III,Glaxo Wellcome Inc., LOWEN, Gregory, Thomas] 130 Waverly Street, Cambridge, MA 02139-4242, US

[ANDREWS STEVEN W, WURSTER JULIE A, HULL CLARENCE E III, WANG EDWARD H, MALONE THOMAS, GUO XIALING, ZHU ZHEN, WANG SHIMIAO] US The present invention relates to organic molecules represented by the general formula (I) wherein: X is O; Y is [C(R2)2]c;. R, R1, R2,-a, b and c are as disclosed in the description; and pharmaceutically acceptable salts thereof, capable of modulating tyrosine kings signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.

[ANDREWS CLARENCE WEBSTER III, CHEUNG MUI, DAVIS-WARD RONDA G, DREWRY DAVID HAROLD, EMMITTE KYLE ALLEN, HUBBARD ROBERT DALE, KUNTZ KEVIN W, LINN JAMES ANDREW, MOOK ROBERT ANTHONY JR, SMITH GARY KEITH, VEAL JAMES MARCIN] US