[MYLES, David C., GULLAPALLI, Rampurna Prasad, ZHANG, Jing Jim, ASKIN, David, ALBERT, Ekaterina, YANG, Lina, HUANG, Shuyan, WANG, Liping] 512 2nd Street, 4th FloorSan Francisco, California 94107 Solid forms of an estrogen receptor (ER) inhibitor, compositions thereof and methods of treating an ER-mediated disorder are provided.

[Todd K. Jones, Sander G. Mills, David Askin, Robert A. Reamer, Richard Desmond, David M. Tschaen, Ralph P. Volante, Ichiro Shinkai] NJ Rahway A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

[David Askin, David Conlon, Yoshinori Kohmura, Jaemoon Lee, Brenda Pipik, Yong-Li Zhong] US NJ Warren Processes for preparing 10-amino-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepine-2-carboxylates and related compounds are disclosed. The preparation of carboxamide derivatives from these carboxylates is also disclosed. The carboxamides are HIV integrase inhibitors and are useful for treating HIV infection and AIDS.

[CONLON DAVID, ZHONG YONG-LI, PIPIK BRENDA, LEE JAEMOON, ASKIN DAVID, KOHMURA YOSHINORI] JP;US

[ASKIN, David, CONLON, David, LEE, Jaemoon, PIPIK, Brenda, ZHONG, Yong-Li, KOHMURA, Yoshinori] 126 East Lincoln Avenue, Rahway, NJ 07065-0907, US

[JONES TODD K, ASKIN DAVID, MILLS SANDER G, REAMER ROBERT A, DESMOND RICHARD, VOLANTE RALPH P, TSCHAEN DAVID M, SHINKAI ICHIRO] US 7751P/5495A 6/28/89:F1 17853Y TITLE OF THE INVENTION PROCESS FOR SYNTHESIS OF FK-506 AND TRICARBONYL INTERMEDIATES A process is described for the total synthesis of the macrolide immunosuppresant, FR-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

[MYLES DAVID C, GULLAPALLI RAMPURNA PRASAD, ZHANG JING JIM, ASKIN DAVID, ALBERT EKATERINA, WANG LIPING, YANG LINA, HUANG SHUYAN] US

[MYLES, David, C., GULLAPALLI, Rampurna Prasad, ZHANG, Jing Jim, ASKIN, David, IE, Thomas, San, PATEL, Mitulkumar, ALBERT, Ekaterina, YANG, Lina, HUANG, Shuyan, WANG, Liping] 512 2nd Street, 4th FloorSan Francisco, California 94107 The present disclosure provides solid and salt forms of an estrogen receptor (ER) inhibitor, compositions thereof and methods of treating a ER-mediated disorder.

[JONES TODD K, ASKIN DAVID, MILLS SANDER G, REAMER ROBERT A, DESMOND RICHARD, VOLANTE RALPH P, TSCHAEN DAVID M, SHINKAI ICHIRO] US 7751P/5495A 6/28/89:F1 17853Y TITLE OF THE INVENTION PROCESS FOR SYNTHESIS OF FK-506 AND TRICARBONYL INTERMEDIATES A process is described for the total synthesis of the macrolide immunosuppresant, FR-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

[Jones, Todd K., Askin, David, Mills, Sander G., Reamer, Robert A., Desmond, Richard, Volante, Ralph P., Tschaen, David M., Shinkai, Ichiro] 126, East Lincoln Avenue P.O. Box 2000, Rahway New Jersey 07065-0900, US A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.