[BERNIER, David, BERNIER, David, CRISTAU, Pierre, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, DÖLLER, Uwe, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, DÖLLER, Uwe, MOSRIN, Marc, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, DÖLLER, Uwe, MOSRIN, Marc, REY, Jullien, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, DÖLLER, Uwe, MOSRIN, Marc, REY, Jullien, TIEBES, Jörg, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki, RINOLFI, Philippe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, DÖLLER, Uwe, MOSRIN, Marc, REY, Jullien, TIEBES, Jörg, WACHENDORFF-NEUMANN, Ulrike] Alfred-Nobel-Str. 5040789 Monheim am Rhein The present invention relates to novel isothiazolamide derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds for controlling harmful microorganisms in crop protection and in the protection of materials, especially for controlling fungi, preferably for controlling fungi in plants or plant seeds.

[TYVOLL, David, TYVOLL, David, FIELDER, Simon, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, PRASHAR, Jognandan, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, PRASHAR, Jognandan, SHEPARD, Michele, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, PRASHAR, Jognandan, SHEPARD, Michele, BLAKE, Iain, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, PRASHAR, Jognandan, SHEPARD, Michele, BLAKE, Iain, MYORS, Richard, TYVOLL, David, FIELDER, Simon, GIMONA, Michele, BARTON, Christopher, PRASHAR, Jognandan, SHEPARD, Michele, BLAKE, Iain, MYORS, Richard, GRASSY, Luke] 61/62 Fitzwilliam LaneDublin 2 An inkjet ink for improving printhead lifetimes includes: an aqueous-based ink vehicle; a colorant; an anti-kogation additive; and an anti-corrosion additive having at least one acetylenic group, the acetylenic group being absent any tertiary or quaternary α-carbon atoms.

[LI, Quanchang, LI, Quanchang, AFEWORKI, Mobae, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, PODSIADLO, Paul, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, PODSIADLO, Paul, BEECKMAN, Jean Willem, Lodewijk, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, PODSIADLO, Paul, BEECKMAN, Jean Willem, Lodewijk, KAMAKOTI, Preeti, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, PODSIADLO, Paul, BEECKMAN, Jean Willem, Lodewijk, KAMAKOTI, Preeti, MAO, Kanmi, LI, Quanchang, AFEWORKI, Mobae, CALABRO, David, Charles, GRIFFIN, David, NINES, Meghan, WESTON, Simon, Christopher, PODSIADLO, Paul, BEECKMAN, Jean Willem, Lodewijk, KAMAKOTI, Preeti, MAO, Kanmi, SHAH, Matu, J.] 1545 Route 22 EastP.O. Box 900Annandale, NJ 08801-0900 Methods of preparing organosilica materials, which is a polymer comprising independent siloxane units of Formula [Z3Z4SiCH2]3 (I), wherein each Z3 represents a hydroxyl group, a C1-C4 alkoxy group or an oxygen atom bonded to a silicon atom of another siloxane unit and each Z4 represents a hydroxyl group, a C1-C4 alkoxy group, a C1-C4 alkyl group, or an oxygen atom bonded to a silicon atom of another siloxane, in the absence of a structure directing agent and/or porogen are provided herein. Processes of using the organosilica materials, e.g., for gas separation, etc., are also provided herein.

[DUNN, David, DUNN, David, SUTTON, Howard Winston Tyrrell, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, RIBIERE, Patrice Georges Antonin, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, RIBIERE, Patrice Georges Antonin, GIBBINGS, Matthew Richard, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, RIBIERE, Patrice Georges Antonin, GIBBINGS, Matthew Richard, GAMBOA MARTINEZ, Sergio Aaron, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, RIBIERE, Patrice Georges Antonin, GIBBINGS, Matthew Richard, GAMBOA MARTINEZ, Sergio Aaron, ANDERSON, Craig, DUNN, David, SUTTON, Howard Winston Tyrrell, DALY, John Ing Chuan, GRANT, Simon Jonathon, HUTCHINGS, Lian, RIBIERE, Patrice Georges Antonin, GIBBINGS, Matthew Richard, GAMBOA MARTINEZ, Sergio Aaron, ANDERSON, Craig, ROGAN, Yulia] Rotary WayConsettDurhamDurham DH8 7ND A catalyst,method of using, and use of a hydrogenation catalyst, preferably palladium on a support, preferably alumina or activated charcoal support. This in the presence of lithium salts, with salts such as theborates being preferred. This provides hydrogenation of precursors to give rise to a stereoselective, such as diastereoselectivebias in the product of alkene hydrogenation using the catalyst. This equation, using the preferred substrate, best illustratesthe invention:

[LI, Quanchang, LI, Quanchang, CALABRO, David, Charles, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, MERTENS, Machteld, Maria Wilfried, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, MERTENS, Machteld, Maria Wilfried, BEUTEL, Tilman, Wolfram, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, MERTENS, Machteld, Maria Wilfried, BEUTEL, Tilman, Wolfram, LAI, Wenyih, Frank, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, MERTENS, Machteld, Maria Wilfried, BEUTEL, Tilman, Wolfram, LAI, Wenyih, Frank, PODSIADLO, Paul, LI, Quanchang, CALABRO, David, Charles, AFEWORKI, Mobae, WESTON, Simon, Christopher, MERTENS, Machteld, Maria Wilfried, BEUTEL, Tilman, Wolfram, LAI, Wenyih, Frank, PODSIADLO, Paul, BEECKMAN, Jean, Willem Lodewijk] 1545 Route 22 EastP.O. Box 900Annandale, NJ 08801-0900 Organosilica materials, which are a polymer of at least one independent monomer of Formula [Z1OZ2OSiCH2]3 (I), wherein each Z1 and Z2 independently represent a hydrogen atom, a C1-C4 alkyl group or a bond to a silicon atom of another monomer and at least one other trivalent metal oxide monomer are provided herein. Methods of preparing and processes of using the organosilica materials, e.g., for catalysis etc., are also provided herein.

[TIEBES, Jörg, TIEBES, Jörg, MOSRIN, Marc, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, GATZWEILER, Elmar, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, GATZWEILER, Elmar, ROSINGER, Christopher Hugh, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, GATZWEILER, Elmar, ROSINGER, Christopher Hugh, BERNIER, David, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, GATZWEILER, Elmar, ROSINGER, Christopher Hugh, BERNIER, David, CRISTAU, Pierre, TIEBES, Jörg, MOSRIN, Marc, REY, Jullien, DÖLLER, Uwe, DRÖGE, Thomas, MAECHLING, Simon, SCHMIDT, Jan Peter, TELSER, Joachim, SCHMUTZLER, Dirk, DIETRICH, Hansjörg, GATZWEILER, Elmar, ROSINGER, Christopher Hugh, BERNIER, David, CRISTAU, Pierre, TSUCHIYA, Tomoki] Alfred-Nobel-Str. 5040789 Monheim am Rhein The invention relates to the technical field of the herbicides and/or plant growth regulators. Specifically, the invention primarily relates to novel isothiazolamides, and compositions comprising said novel isothiazolamides. Further, the present invention relates to processes for the preparation said novel isothiazolamides and their use as herbicides and/or plant growth regulators.

[SIMON, Julian, SIMON, Julian, JOHNSON, Graham, SIMON, Julian, JOHNSON, Graham, RUBEL, Edwin W., SIMON, Julian, JOHNSON, Graham, RUBEL, Edwin W., RAIBLE, David W., SIMON, Julian, JOHNSON, Graham, RUBEL, Edwin W., RAIBLE, David W., GONZALEZ, Mario D., SIMON, Julian, JOHNSON, Graham, RUBEL, Edwin W., RAIBLE, David W., GONZALEZ, Mario D., MELTZER, Peter C., SIMON, Julian, JOHNSON, Graham, RUBEL, Edwin W., RAIBLE, David W., GONZALEZ, Mario D., MELTZER, Peter C., MIAO, Weishi] 4311 11th Avenue NESuite 500Seattle, Washington 98105;1100 Fairview Avenue NorthSeattle, Washington 98109;474 39th Avenue EastSeattle, Washington 98112 Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed. Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are al

[CHEN, Ning, CHEN, Ning, CHEN, Xiaoqi, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, DEBENEDETTO, Mikkel V., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, DEBENEDETTO, Mikkel V., FARRELL, Robert P., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, DEBENEDETTO, Mikkel V., FARRELL, Robert P., HEDLEY, Simon J., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, DEBENEDETTO, Mikkel V., FARRELL, Robert P., HEDLEY, Simon J., JUDD, Ted C., CHEN, Ning, CHEN, Xiaoqi, CHEN, Yinhong, CHENG, Alan C., CONNORS, Richard V., DEIGNAN, Jeffrey, DRANSFIELD, Paul John, DU, Xiaohui, FU, Zice, HEATH, Julie Anne, HORNE, Daniel B., HOUZE, Jonathan, KALLER, Matthew R., KHAKOO, Aarif Yusuf, KOPECKY, David John, LAI, Su-Jen, MA, Zhihua, MCGEE, Lawrence R., MEDINA, Julio C., MIHALIC, Jeffrey T., NISHIMURA, Nobuko, OLSON, Steven H., PATTAROPONG, Vatee, SWAMINATH, Gayathri, WANG, Xiaodong, YANG, Kevin, YEH, Wen-Chen, DEBENEDETTO, Mikkel V., FARRELL, Robert P., HEDLEY, Simon J., JUDD, Ted C., KAYSER, Frank] One Amgen Center DriveThousand Oaks, California 91320-1799 Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures where the definitions of the variables are provided herein.

[KNIGHT, Simon, Christopher, KNIGHT, Simon, Christopher, PRITCHETT, David, John, KNIGHT, Simon, Christopher, PRITCHETT, David, John, KASTING, Thomas, P., KNIGHT, Simon, Christopher, PRITCHETT, David, John, KASTING, Thomas, P., BOX, Mark, Edward, KNIGHT, Simon, Christopher, PRITCHETT, David, John, KASTING, Thomas, P., BOX, Mark, Edward, YU, Raymond] Scudamore RoadLeicester Leicestershire LE3 1UG A dispenser for dispensing a flowable product from a container has a pump module (2) mounted on the container (1) at an opening thereof. The pump module includes a pump body, which defines a pump chamber and a pump chamber inlet for product to flow from the container interior into the pump chamber. A pump actuator (4) is operable in a pumping stroke relative to the pump body to vary the volume of the pump chamber and dispense the product. The pump includes a movable body portion (3) which is operable in a displacement stroke into the container. The movable portion has a displacement body (34) with a product-engaging face directed onto an interior product space of the container upstream of the pump chamber inlet, to assist priming. Below this a disrupter member (6), a grid of narrow bars, projects to penetrate the product.

[SANTHANAM, Uma, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, ANDERSON, Glen Thomas, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, ANDERSON, Glen Thomas, WYBORSKI, Russell J., SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, ANDERSON, Glen Thomas, WYBORSKI, Russell J., DUTTON, Simon, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, ANDERSON, Glen Thomas, WYBORSKI, Russell J., DUTTON, Simon, SCHOEN, Jeanine, SANTHANAM, Uma, IDKOWIAK-BALDYS, Jolanta, THORN LEESON, Daniel, GONZALEZ, Anthony David, YADAV, Pradeep H., MARTINEZ-AVILA, Olga Maria, POLICELLI, Lauren, ANDERSON, Glen Thomas, WYBORSKI, Russell J., DUTTON, Simon, SCHOEN, Jeanine, VON BARGEN, Dana] c/o Joan McGillycuddy777 Third AvenueNew York, New York 10017 Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.