[KLEINSCHROTH JUERGEN, JUERGEN KLEINSCHROTH, HARTENSTEIN JOHANNES, JOHANNES HARTENSTEIN, BARTH HUBERT, HUBERT BARTH, SCHAECHTELE CHRISTOPH, CHRISTOPH SCHAECHTELE, RUDOLPH CLAUS, CLAUS RUDOLPH, WEINHEIMER GUENTER, GUENTER WEINHEIMER] Novel indolocarbazole derivatives of the general formula I <IMAGE> in which R<1> and R<2> are identical or different and denote hydrogen, a straight-chain or branched alkyl group having 1 to 6 C atoms, a benzyl group, an unsubstituted or substituted aminoalkyl group having up to 12 C atoms, an alkoxycarbonylalkyl radical having up to 6 C atoms, a radical -CH2-CO-NR<3>R<4> in which R<3> and R<4> are identical or different and represent hydrogen, an alkyl group having 1 to 4 C atoms or a benzyl group, or R<1> and/or R<2> denote a haloalkyl, hydroxyalkyl or alkoxyalkyl radical each having up to 6 C atoms, a benzoyloxyalkoxyalkyl, acetyloxyalkoxyalkyl or hydroxyalkoxyalkyl radical each having up to 11 C atoms, or an acyl group having 1 to 4 C atoms or R<1> and R<2> together denote an alkylene group having 2 to 4 C atoms, optionally substituted by hydroxyl, C1-4-alkoxy or amino, X and Y are either identical and in each case both denote hydrogen, or X and Y are different, one of the radicals X or Y representing hydrogen and the other of the two radicals denoting a hydroxyl or an alkoxy group having up to 4 C atoms, with the proviso that not all radicals R<1>, R<2>, X and Y simultaneously denote hydrogen, and their pharmacologically acceptable salts, process for the preparation of the compounds I or of regioisomer mixtures of two of these compounds I and medicines containing at least one of the compounds I.

[KLEINSCHROTH JUERGEN, JUERGEN KLEINSCHROTH, HARTENSTEIN JOHANNES, JOHANNES HARTENSTEIN, BARTH HUBERT, HUBERT BARTH, SCHAECHTELE CHRISTOPH, CHRISTOPH SCHAECHTELE, RUDOLPH CLAUS, CLAUS RUDOLPH, WEINHEIMER GUENTER, GUENTER WEINHEIMER]

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] DE

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] <P>PROBLEM TO BE SOLVED: To provide an indolocarbazole imide for producing a pharmaceutical composition, which is used for the treatment and/or as a prophylactic and an immunosuppressant against cancers, virus diseases, heart and vascular diseases, bronchopulmonary diseases, central nervous system degenerative diseases, inflammatory diseases, immune system disorders and psoriasis. <P>SOLUTION: The indolocarbazole imide compound represented by general formula I and its use are obtained. The compound can be used for the treatment and/or as a remedy and an immunosuppressant against cancers, virus diseases (e.g. HIV infection), heart and vascular diseases (e.g. hypertension, thrombosis, heart rhythm disorder and atherosclerosis), bronchopulmonary diseases, central nervous system degenerative diseases (e.g. Alzheimer\'s disease), inflammatory diseases (e.g. rheumatism and arthritis), immune system disorders (e.g. allergy) and psoriasis. <P>COPYRIGHT: (C)2004,JPO

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE JUERGEN] DE

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] DE

[KLEINSCHROTH JUERGEN DR, HARTENSTEIN JOHANNES DR, SCHAECHTELE CHRISTOPH DR, RUDOLPH CLAUS DR, BARTH HUBERT DR, ARANDA JULIAN DR, BETCHE HANS JUERGEN DR] DE The object of the invention is the use of indolocarbazole imides of general formula (I) for the production of medicaments for the treatment and/or prevention of cancer, viral diseases (e.g. HIV infections), cardiac and circulatory disorders (e.g. hypertension, thrombosis, cardiac rhythm irregularities, atherosclerosis), broncho-pulmonary diseases, degenerative diseases of the central nervous system (e.g. Alzheimer\'s disease), inflammatory conditions (e.g. rheumatism, arthritis) diseases of the immune system (e.g. allergies) and psoriasis, or for use as immunosuppressors, and novel compounds of formula (I).

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] DE The present invention is concerned with the use of indolocarbazole imides of the general formula (I): for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases (for example HIV infections), heart and blood vessel diseases (for example high blood pressure, thromboses, heart rhythm disturbances and atheroscleroses), bronchopulmonary diseases, degenerative diseases of the central nervous system (for example Alzheimer\'s disease), inflammatoryl diseases (for example rheumatism and arthritis), diseases of the immune system (for example allergies), as well as psoriasis and for use as immune suppressives; as well as new compounds of general formula (I).

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] DE

[KLEINSCHROTH JUERGEN, SCHAECHTELE CHRISTOPH, HARTENSTEIN JOHANNES, RUDOLPH CLAUS, BARTH HUBERT, ARANDA JULIAN, BETCHE HANS JUERGEN] DE