[Christopher A. Tacklind, Aragon Burlingham, Daniel T. Adams, Mark Diel, Zinovy Dolgonosov, Brian Lamb, Jean-Pierre Krauer, Helen D. Shaughnessy, Ed West, Leung Wing Fai, Derek Tong Kai Chun, Yung Wai Lam, Fong Ming, Kwan Yat Shan, Chan Wing Keung, Lam Wing Cheung] US CA Palo Alto An alignment device provides one or more references, such as laser lines and planes in horizontal and vertical orientations. One version of the alignment device includes an optics mounting assembly situated in a pivot socket on a frame to provide an output beam. A spring system and one or more alignment assemblies align and secure the optics mounting assembly in the socket. As a result, the output beam has a desired orientation with respect to true level. The spring system holds the optics mounting assembly in communication with the alignment assemblies to reduce system backlash. One implementation of the pivot socket has a surface in the form of a sphere's interior surface. A set of support members on the optics mounting assembly rest on the pivot socket's spherical surface—causing the output reference beam to extend from the center of a sphere including the socket's spherical surface. This reduces the translation of the output reference beam's origin when the optics mounting assembly pivots in the socket.

[Vallee Bert L.(Brookline,MA), Keung Wing-Ming(Wayland,MA)] Method for inhibiting aldehyde dehydrogenase activity using daidzin and/or daidzin analog and/or daidzin or daidzin analog in combination with a factor or factors which increase the bioavailability of the daidzin or daidzin analog, as ALDH-I inhibitory compounds or compositions. Such inhibitory compounds or compositions are useful as pharmaceutical compositions in methods for the treatment of alcohol dependence (i.e., alcoholism) or alcohol abuse, for alcohol sensitization, for extinguishing an alcohol-drinking response, for suppressing an urge for alcohol, for inducing alcohol intolerance, for preventing alcoholism in an individual with or without a susceptibility or predisposition to alcoholism or alcohol abuse, and for limiting alcohol consumption in an individual whether or not genetically predisposed.

[Hua Hong Tan, Chee Kay Chow, Zong Xiang Cai, Wei Ming Xian, Yao Hong Wu, Wing Keung Lam] SG Singapore A manufacturing system includes a substrate disposed on a conveyer system. The conveyer system includes a pair of side supports. The substrate is moved on the conveyer system until the substrate is disposed over a bottom support block. The bottom support block is raised to physically contact the substrate. A transfer arm module is provided. The transfer arm module includes a flat bottom surface and an opening formed in the flat bottom surface. The transfer arm module is disposed with the flat bottom surface physically contacting the substrate opposite the bottom support block. A vacuum is enabled through the opening of the transfer arm module. The substrate is lifted off the bottom support block using the vacuum. The substrate is moved over a printing pallet using the transfer arm module. The vacuum is disabled when the substrate is in a positioning area of the printing pallet.

[Jeff Zablocki, Matthew Abelman, Michael Organ, Yaroslav Bilokin, Elfatih Elzein, Tetsuya Kobayashi, Rao Kalla, Thao Perry, Xiaofen Li, Robert Jiang, Ivan Diamond, Lina Yao, Peidong Fan, Maria Pia Arolfo, Zhan Jiang, Wing Ming Keung, Guoxin Tao] US CA Foster City Disclosed are novel isoflavone derivatives having the structure of Formula Iwhich are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

[VALLEE BERT L, KEUNG WING MING] US

[KEUNG WING-MING] US

[LI FENGXIAO, YU KING CHEUNG, CHAN WING CHEONG, TONG CHUN KEUNG, ZHAN LI MING, YAO QING YUN, ZHONG JIE LING, LAO LE MIAN] HK;CN

[VALLEE BERT L, KEUNG WING MING] US

[VALLEE, Bert, L., KEUNG, Wing-Ming] 250 Longwood Avenue Boston, MA 02115;300 Boylston Street #712 Boston, MA 02116;2 Juniper Lane Wayland, MA 01778 A method for the treatment of alcohol abuse using diadzin and compounds analogous to diadzin is disclosed. Also disclosed is a method for screening compounds having antidipsotropic activity.

[Neil McLellan, Ming Wang Sze, Wing Keung Lam, Kin-wai Wong] HK New Territories An integrated circuit package is provided. The package includes a substrate having first and second surfaces and a plurality of conductive traces therebetween. A semiconductor die is mounted on the first surface of the substrate and an adapter disposed on the semiconductor die. A plurality of wire bonds connect the semiconductor die to ones of the conductive traces of the substrate, and an encapsulant encapsulates the wirebonds and a remainder of the semiconductor die. A heat spreader has a top portion in contact with the adapter and at least one sidewall extends from the top portion. At least a portion of the at least one sidewall is in contact with the substrate. A ball grid array is disposed on the second surface of the substrate, bumps of the ball grid array being in electrical connection with ones of the conductive traces.