[PARK, Chun Eung, PARK, Chun Eung, JANG, Young Koo, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, RYU, Eun Ju, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, RYU, Eun Ju, MAENG, Cheol Young] 26, Jong-roJongro-guSeoul 03188 The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. The compound of Chemical Formula (1) or pharmaceutically acceptable salt thereof acts as a positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5), thereby being useful in the prevention or treatment of disorder mediated by glutamate dysfunction and mGluR5.

[GWAK, Hye Sun 곽혜선, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, LEE, Kyung Eun 이경은, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, LEE, Kyung Eun 이경은, PARK, Jin Young 박진영] 52, Ewhayeodae-gil, 120-750 서울시 서대문구 이화여대길 52, SeoulSeodaemun-gu,Seoul 120-750 The present invention relates to a complex composition having enhanced efficacy and safety for treating or alleviating dysmenorrhea. More particularly, the present invention relates to a complex composition for treating or alleviating dysmenorrhea, wherein the composition uses aceclofenac or a pharmaceutically acceptable salt thereof as a main ingredient, and is additionally combined with scopolamine or a pharmaceutically acceptable salt thereof such that a dose of aceclofenac or a pharmaceutically acceptable salt thereof is reduced in order to exhibit, in a small dose, efficacy for pain which is equal to or better than the efficacy provided by a dose of a typical prescription drug with minimal side effects.

[KIM, Young Ju 김영주, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KWEON, Jae Hong 권재홍, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KWEON, Jae Hong 권재홍, LEE, Sung Ah 이성아, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KWEON, Jae Hong 권재홍, LEE, Sung Ah 이성아, CHOI, Kwang Do 최광도, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KWEON, Jae Hong 권재홍, LEE, Sung Ah 이성아, CHOI, Kwang Do 최광도, KO, Dong Hyun 고동현, KIM, Young Ju 김영주, KIM, Eun Sun 김은선, LEE, Ji Yun 이지윤, LEE, Hyuk Woo 이혁우, KWEON, Jae Hong 권재홍, LEE, Sung Ah 이성아, CHOI, Kwang Do 최광도, KO, Dong Hyun 고동현, HEO, Seung Pyeong 허승평] 330, Dongho-ro, 04560 서울시 중구 동호로 330, SeoulJung-gu,Seoul 04560 The present invention relates to a novel crystal form of a benzimidazole derivative and a preparation method thereof. The novel crystal form according to the present invention is not denatured under harsh lighting conditions for a long time, has low moisture absorption properties and significantly low static electricity induction properties, thereby allowing the crystal form to be formulated easily. In addition, the crystal form has very excellent inherent-stability so as to be useful for long-term storage.

[CHANG, Jin Sook 장진숙, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, NA, Kwang Ho 나광호, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, NA, Kwang Ho 나광호, SHIN, Yong Uk 신용욱, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, NA, Kwang Ho 나광호, SHIN, Yong Uk 신용욱, LEE, Jae Min 이재민, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, NA, Kwang Ho 나광호, SHIN, Yong Uk 신용욱, LEE, Jae Min 이재민, LEE, Jae Hee 이재희, CHANG, Jin Sook 장진숙, KIM, Ju Eun 김주은, KIM, So Young 김소영, NA, Kwang Ho 나광호, SHIN, Yong Uk 신용욱, LEE, Jae Min 이재민, LEE, Jae Hee 이재희, HEO, In Kyung 허인경] (Ssangnim-dong) 330, Dongho-ro 100-400 서울시 중구 동호로 330 (쌍림동), SeoulJung-gu,Seoul 100-400 The present invention relates to a recombinant microorganism producing quinolinic acid - in particular, a microorganism producing quinolinic acid and having a protein of SEQ ID NO: 1, the activity of which is reduced or removed, and to a method for producing quinolinic acid using the same.

[KIM, Ju Eun 김주은, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, CHOI, Hyeon 최현, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, JOO, Hyo Sook 주효숙, KIM, Ju Eun 김주은, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열] 128, Yeoui-daero 07336 서울시 영등포구 여의대로 128, SeoulYeongdeungpo-gu, Seoul 07336 The present invention relates to a super absorbent resin and a method for preparing the same. More specifically, the present invention relates to a super absorbent resin, which comprises a double cross-linkage structure derived from alkylene glycol polyhydric (meth)acrylate and modified nano-clay and thus exhibits improved physical properties, and to a method for preparing the same. According to the preparation method of the present invention, the modified nano-clay and the alkylene glycol polyhydric (meth)acrylate are used as internal cross-linking agents in the process of preparing the super absorbent resin, and thus can contribute to the improvements in the cross-linking degree and physical properties of the super absorbent resin.

[KIM, Eunhee 김은희, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, IN, Tae-Kyu 인태규, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, IN, Tae-Kyu 인태규, JOO, Choun-Ki 주천기] 99, Daehak-ro 305-764 대전시 유성구 대학로 99, DaejeonYuseong-guDaejeon 305-764 The present invention relates to a novel methanone derivative, a preparation method for same, and a pharmaceutical composition, for preventing or treating retinal diseases, containing same as an active ingredient. A novel methanone derivative, an optical isomer of same, or pharmaceutically acceptable salts of same, according to the present invention, has excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, a composition containing same as an active ingredient can be utilized as a pharmaceutical composition for preventing or treating retinal diseases such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.

[KIM, Joong Soo 김중수, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, SONG, Eun Kyoung 송은경, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, SONG, Eun Kyoung 송은경, SONG, Nak-Kyu 송낙규, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, SONG, Eun Kyoung 송은경, SONG, Nak-Kyu 송낙규, HONG, Dae Sik 홍대식, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, SONG, Eun Kyoung 송은경, SONG, Nak-Kyu 송낙규, HONG, Dae Sik 홍대식, KIM, Woo Ri 김우리, KIM, Joong Soo 김중수, KWON, Hyuck Ju 권혁주, CHOI, Yi Young 최이영, LEE, Ki Soo 이기수, SONG, Eun Kyoung 송은경, SONG, Nak-Kyu 송낙규, HONG, Dae Sik 홍대식, KIM, Woo Ri 김우리, KIM, Si Yong 김시용] 128, Yeoui-daero, 07336 서울시 영등포구 여의대로 128, SeoulYeongdeungpo-gu,Seoul 07336 The present invention relates to an ethylene/1-hexene or ethylene/1-butene copolymer having outstanding working properties. The ethylene/1-hexene or ethylene/1-butene copolymer according to the present invention has a high molecular weight and a wide molecular weight distribution and has outstanding working properties and has outstanding environmental stress cracking resistance and hence can be used in high-pressure heating piping, mining pipes or large-diameter pipes and the like.

[PARK, Sung Soo 박성수, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, JOO, Hyo Sook 주효숙, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, JOO, Hyo Sook 주효숙, PARK, Sung Hyun 박성현, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, JOO, Hyo Sook 주효숙, PARK, Sung Hyun 박성현, CHOI, Hee Jung 최희정, PARK, Sung Soo 박성수, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, JOO, Hyo Sook 주효숙, PARK, Sung Hyun 박성현, CHOI, Hee Jung 최희정, YOON, Ki Youl 윤기열] 128, Yeoui-daero, Yeongdeungpo-gu 07336 서울시 영등포구 여의대로 128, SeoulSeoul 07336 The present invention relates to a super-absorbent polymer having excellent properties, both centrifugal retention capacity (CRC) and absorption under pressure (AUP) having been improved by introducing a surface crosslinked layer crosslinked by surface-modified inorganic particles, and to a method for preparing the same. The super-absorbent polymer comprises: a base resin powder containing a crosslinked polymer of water-soluble ethylene-based unsaturated monomers having an at least partially neutralized acidic group; and a surface crosslinked layer formed on the base resin powder, wherein inorganic particles may be chemically bound to the crosslinked polymer contained in the surface crosslinked layer, via an oxygen-containing bond or a nitrogen-containing bond.

[KIM, Eunhee 김은희, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, IN, Tae-Kyu 인태규, KIM, Eunhee 김은희, YOO, Sung-Eun 유성은, KANG, Nam Sook 강남숙, KOO, Tae-Sung 구태성, PARK, Min-Young 박민영, KIM, Young-Hoon 김영훈, BAE, Hyun-Ju 배현주, KIM, Jin-Woo 김진우, IN, Tae-Kyu 인태규, JOO, Choun-Ki 주천기] 99 Daehak-ro, Yuseong-gu 305-764 대전광역시 유성구 대학로99, DaejeonDaejeon 305-764 The present invention relates to a novel indene derivative, a preparation method for same, and a pharmaceutical composition, for preventing or treating retinal diseases, containing same as an active ingredient. A novel indene derivative, an optical isomer of same, or pharmaceutically acceptable salts of same, according to the present invention, has excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, a composition containing same as an active ingredient can be utilized as a pharmaceutical composition for preventing or treating retinal diseases such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.

[JOO, Hyo Sook 주효숙, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, PARK, Sung Soo 박성수, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, PARK, Sung Soo 박성수, PARK, Sung Hyun 박성현, JOO, Hyo Sook 주효숙, YOON, Ki Youl 윤기열, KIM, Gi Cheul 김기철, KIM, Ju Eun 김주은, CHOI, Hyeon 최현, CHOI, Hee Jung 최희정, PARK, Sung Soo 박성수, PARK, Sung Hyun 박성현, LEE, Myung Han 이명한] 128, Yeoui-daero, 07336 서울시 영등포구 여의대로 128, SeoulYeongdeungpo-gu,Seoul 07336 The present invention relates to a super absorbent resin and a method for preparing the same, wherein the super absorbent resin has more enhanced gel strength and exhibits excellent physical properties, such as the improvement in both centrifuge retention capacity (CRC) and absorbency under pressure (AUP), due to the optimized cross-linkage structure of a base resin powder inside a surface cross-linkage layer. The super absorbent resin comprises: a base resin powder containing a first cross-linked polymer of a water-soluble ethylene-based unsaturated monomer having an at least partially neutralized acidic group; and a surface cross-linkage layer containing a second cross-linked polymer obtained by further cross-linking the first cross-linked polymer and formed on the base resin powder, wherein in the first cross-linked polymer, inorganic particles may be chemically linked to each other via a cross-linkage, an oxygen-containing linkage (-O-), or a nitrogen-containing linkage (-NR-; R is hydrogen or a C1-C3 alkyl group or an amide linkage).