[KIM, Tae Won 김태원, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, JUNG, Ha Na 정하나, LEE, Dae Hee 이대희, JUNG, Seang Hwan 정승환, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Bong Choel 김봉철] 330, Dongho-ro, 04560 서울시 중구 동호로 330, SeoulJung-gu,Seoul 04560 The present invention relates to a biomarker for predicting sensitivity to a protein kinase inhibitor and a use thereof, and provides a marker for predicting sensitivity to a protein kinase inhibitor, a composition, a kit, and a prediction method. According to the present invention, an effect of predicting sensitivity to a protein kinase inhibitor is excellent, and thus the present invention can be useful for cancer treatment.

[KIM, Tae Won 김태원, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Bong Choel 김봉철] 88, Olympic-ro 43-gil 138-736 서울시 송파구 올림픽로43길 88, SeoulSongpa-guSeoul 138-736 The present invention relates to a novel biomarker for predicting sensitivity to an epidermal growth factor receptor (EGFR)-targeting agent, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the EGFR-targeting agent, the biomarker comprising the Recepteur d'Origine Nantais (RON) gene; a composition for predicting sensitivity to the EGFR-targeting agent, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression or activity of the protein of the gene; a composition for enhancing sensitivity to the EGFR-targeting agent, the composition comprising, as an active ingredient, an inhibitor inhibiting the expression of the gene, or the expression or activity of the protein of the gene; a kit for predicting sensitivity to the EGFR-targeting agent, the kit comprising the compositions; and a method for predicting sensitivity to the EGFR-targeting agent. According to the present invention, the present invention has an excellent effect of predicting sensitivity to the EGFR-targeting agent for colon cancer, and thus the present invention may be usefully employed for treating colon cancer.

[KIM, Tae Won 김태원, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Bong Choel 김봉철] 88, Olympic-ro 43-gil 138-736 서울시 송파구 올림픽로43길 88, SeoulSongpa-guSeoul 138-736 The present invention relates to a novel biomarker for predicting sensitivity to a poly ADP ribose polymerase (PARP) inhibitor, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the PARP inhibitor, the biomarker comprising the p53 gene and/or the DNA-dependent protein kinase (DNA-PK) gene; a composition for predicting sensitivity to the PARP inhibitor, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression of the protein of the gene; a kit for predicting sensitivity to the PARP inhibitor, the kit comprising the composition; a method for predicting sensitivity to the PARP inhibitor; a sensitivity enhancer for enhancing the sensitivity of a subject to the PARP inhibitor; and a pharmaceutical composition for preventing or treating cancer, the pharmaceutical composition comprising, as active ingredients, the sensitivity enhancer and the PARP inhibitor. According to the present invention, the present invention has an excellent effect of predicting sensitivity to the PARP inhibitor, and thus may be usefully employed for treating colon cancer.

[KIM, Tae Won 김태원, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Tae Won 김태원, JIN, Dong Hoon 진동훈, HONG, Seung Woo 홍승우, MOON, Jai Hee 문재희, SHIN, Jae Sik 신재식, HWANG, Ih Yeon 황이연, KIM, Jeong Hee 김정희, LEE, Ha Reum 이하름, CHOI, Eun Kyoung 최은경, KIM, Seung Mi 김승미, JUNG, Soo A 정수아, HA, Seung Hee 하승희, LEE, Dae Hee 이대희, LEE, Eun Young 이은영, LEE, Seul 이슬, LEE, Jung Shin 이정신, CHOI, Eun Kyung 최은경, LEE, Jae Lyun 이재련, HONG, Yong Sang 홍용상, KIM, Kyu Pyo 김규표, KIM, Jeong Eun 김정은, PARK, Seong Joon 박성준, KIM, Bong Choel 김봉철] 88, Olympic-ro 43-gil, 138-736 서울시 송파구 올림픽로43길 88, SeoulSongpa-guSeoul 138-736 The present invention relates to a novel biomarker for predicting sensitivity to an MET inhibitor, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting sensitivity to the MET inhibitor, the biomarker comprising the Immunoglobulin Superfamily member 1 (IGSF1, NM_001555.2) gene; a composition for predicting sensitivity to the MET inhibitor, the composition comprising a pharmaceutical preparation for measuring the degree of expression of the gene in the biomarker, or the degree of expression of the protein of the gene; a pharmaceutical composition for treating diseases related to the dysregulation of the MET signaling pathway, the pharmaceutical composition comprising, as an active ingredient, an inhibitor inhibiting the expression of the gene in the biomarker, or the expression or activity of the protein of the gene; a kit for predicting sensitivity to the MET inhibitor, the kit comprising the compositions; and a method for predicting sensitivity to the MET inhibitor. According to the present invention, the present invention has an excellent effect of predicting sensitivity to the MET inhibitor for stomach cancer or lung cancer, and thus the present invention may be usefully employed for treating stomach cancer or lung cancer.

[LEE, Eun Yong 이은용, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Gui Hang 이귀항, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Gui Hang 이귀항, PAEK, Mi Jeong 백미정, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Gui Hang 이귀항, PAEK, Mi Jeong 백미정, JUNG, Won Ho 정원호, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Gui Hang 이귀항, PAEK, Mi Jeong 백미정, JUNG, Won Ho 정원호, CHOI, Bong Goo 최봉구, LEE, Eun Yong 이은용, LEE, Ji Ae 이지애, JUNG, Byoung Soo 정병수, JUNG, Yong Su 정용수, HWANG, Jae Suk 황재석, LEE, Gui Hang 이귀항, PAEK, Mi Jeong 백미정, JUNG, Won Ho 정원호, CHOI, Bong Goo 최봉구, CHOI, Ho Kyoung 최호경] 508ho, 184, Gasan digital 2-ro 08501 서울시 금천구 가산디지털2로 184, 508호, SeoulGeumcheon-guSeoul 08501 The present invention provides: a novel structure of a phosphorus-based epoxy compound having a high phosphorus (P) content and having high heat resistance and low dielectric characteristics; a method for preparing a phosphorus-based epoxy compound having a high phosphorus content and having high heat resistance and low dielectric characteristics through a preparation method in which an epoxy group is introduced into a phosphorus-based hydroxy compound by using an epoxy compound; and a phosphorus-based epoxy composition containing the same.

[LIM, Young Kyung 임영경, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, KIM, Tae Hyun 김태현, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, KIM, Tae Hyun 김태현, KIM, Sun Young 김선영, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, KIM, Tae Hyun 김태현, KIM, Sun Young 김선영, JO, Kwang Hyun 조광현, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, KIM, Tae Hyun 김태현, KIM, Sun Young 김선영, JO, Kwang Hyun 조광현, KANG, Ki Mun 강기문, LIM, Young Kyung 임영경, JEONG, Eun Hee 정은희, HWANG, Yi Jung 황의중, CHO, Kwan Ho 조관호, LEE, Se Byeong 이세병, SHIN, Dong Ho 신동호, PARK, Jeong Hoon 박정훈, KIM, Dae Yong 김대용, KIM, Joo Young 김주영, KIM, Tae Hyun 김태현, KIM, Sun Young 김선영, JO, Kwang Hyun 조광현, KANG, Ki Mun 강기문, JEONG, Ho Jin 정호진] 323, Ilsan-ro, Ilsandong-gu 10408 경기도 고양시 일산동구 일산로 323, Gyeonggi-doGoyang-si,Gyeonggi-do 10408 The present invention relates to an in vivo radiation amount measuring instrument. An in vivo radiation amount measuring instrument according to the present invention comprises: a main body elongated along an in vivo inserting direction and capable of supplying a fluid; an expanding part having at least a portion thereof fixed or connected to the main body and capable of being expanded and contracted by means of the outflow/inflow of the fluid; and a radiation measuring part disposed on the expanding part and measuring the amount of surface radiation distribution on in vivo tissue which the expanding part contacts by expanding.

[KIM, Moonsoo, KIM, Moonsoo, LEE, Chaewoon, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Hyun, Jung, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Hyun, Jung, KIM, Hye, Kyoung, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Hyun, Jung, KIM, Hye, Kyoung, LEE, Jae, Il, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Hyun, Jung, KIM, Hye, Kyoung, LEE, Jae, Il, KIM, Misoon, KIM, Moonsoo, LEE, Chaewoon, LEE, Gilnam, YOON, Cheolhwan, SEO, Jeongbeob, KIM, Jay, Hak, LEE, Minwoo, JEONG, Hankyul, CHOI, Hyang, JUNG, Myung, Eun, LEE, Ki, Nam, KIM, Hyun, Jung, KIM, Hye, Kyoung, LEE, Jae, Il, KIM, Misoon, CHOI, Soongyu] 335, Pangyo-ro, Bundang-guSeongnam-si, Gyeonggi-do13488;132, Teheran-roGangnam-gu, Seoul06235 The disclosure provides novel chemical compounds represented by Formula (I) or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is -CH=CR3C(O)Nr4R5, -C=CC(O)NR4R5,-C≡ CC(0)NR4R5, or (II).

[GWAK, Hye Sun 곽혜선, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, LEE, Kyung Eun 이경은, GWAK, Hye Sun 곽혜선, KIM, Kwan Chang 김관창, CHOI, Ji Ha 최지하, JUNG, Sung Ae 정성애, LEE, Rena 이레나, HA, Eun Hee 하은희, KIM, Young Ju 김영주, PANG, Eun Kyoung 방은경, PARK, Sunny 박선이, JEONG, Eu Rim 정유림, LEE, Kyung Eun 이경은, PARK, Jin Young 박진영] 52, Ewhayeodae-gil, 120-750 서울시 서대문구 이화여대길 52, SeoulSeodaemun-gu,Seoul 120-750 The present invention relates to a complex composition having enhanced efficacy and safety for treating or alleviating dysmenorrhea. More particularly, the present invention relates to a complex composition for treating or alleviating dysmenorrhea, wherein the composition uses aceclofenac or a pharmaceutically acceptable salt thereof as a main ingredient, and is additionally combined with scopolamine or a pharmaceutically acceptable salt thereof such that a dose of aceclofenac or a pharmaceutically acceptable salt thereof is reduced in order to exhibit, in a small dose, efficacy for pain which is equal to or better than the efficacy provided by a dose of a typical prescription drug with minimal side effects.

[PARK, Chun Eung, PARK, Chun Eung, JANG, Young Koo, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, RYU, Eun Ju, PARK, Chun Eung, JANG, Young Koo, SHIN, Yong Je, KIM, Ji Yeon, HAM, Seung Mo, KIM, Yong Gil, MIN, Hye Kyung, CHA, Soo Bong, JUNG, Hyo Jun, LEE, Ju Young, HAN, Seung Nam, CHUNG, Jin Yong, CHOI, Eun Ju, JOUNG, Chan Mi, PARK, Jong Sil, LEE, Ji Won, CHO, Nahm Ryune, RYU, Eun Ju, MAENG, Cheol Young] 26, Jong-roJongro-guSeoul 03188 The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. The compound of Chemical Formula (1) or pharmaceutically acceptable salt thereof acts as a positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5), thereby being useful in the prevention or treatment of disorder mediated by glutamate dysfunction and mGluR5.

[KIM, Joong Kyu 김중규, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Hak-Sung 김학성, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Hak-Sung 김학성, LEE, Joong-jae 이중재, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Hak-Sung 김학성, LEE, Joong-jae 이중재, JO, Seong-Min 조성민, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Hak-Sung 김학성, LEE, Joong-jae 이중재, JO, Seong-Min 조성민, RYOU, Jeong-Hyun 유정현, KIM, Joong Kyu 김중규, PARK, Yun-Hee 박윤희, CHOI, Hyo Jung 최효정, JUNG, Ji Eun 정지은, KIM, Sun Young 김선영, CHO, Jong Un 조종운, JUNG, Doo Hwan 정두환, MIN, Ji Young 민지영, KIM, Yong Zu 김용주, PARK, Tae Kyo 박태교, WOO, Sung Ho 우성호, KIM, Hak-Sung 김학성, LEE, Joong-jae 이중재, JO, Seong-Min 조성민, RYOU, Jeong-Hyun 유정현, KIM, Tae Yoon 김태윤] 8-26, Munpyeongseo-ro 34302 대전광역시 대덕구 문평서로 8-26, DaejeonDaedeok-guDaejeon 34302;291, Daehak-ro 34141 대전광역시 유성구 대학로 291, DaejeonYuseong-guDaejeon 34141 The present invention relates to a drug conjugate using a repebody derivative, and a preparation method thereof and, more specifically, to a repebody derivative drug conjugate (RDC) in which a drug, a toxin, a ligand, and a substance having activity such as detection marking are conjugated to repebody, which exhibits substrate specificity by connecting a leucine-rich repeat (LRR) structure originated from a variable lymphocyte receptor (VLR) as a variable region on the N-terminus of an LRR family protein having an alpha helical capping motif, and a preparation method thereof. The RDC according to the present invention is a conjugate which is combined with a compound having high substrate specificity and excellent tissue and tumor penetration that repebody provides, and biological activity. As such, the RDC has the advantages of having superior efficacy compared to the case of using repebody alone, and having specific selectivity compared to the case of using the compound alone. Due to these features, the RDC is expected to be utilized in the treatment of tumors by combining, with repebody, which specifically binds to a protein overexpressed on cancer cells, a toxin that kills cells, to thereby selectively kill only the cancer cells.