[LIU, Hong 柳红, LIU, Hong 柳红, GENG, Meiyu 耿美玉, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, HE, Yulong 何玉龙, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, HE, Yulong 何玉龙, LI, Chunpu 李淳朴, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, HE, Yulong 何玉龙, LI, Chunpu 李淳朴, DING, Jian 丁健, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, HE, Yulong 何玉龙, LI, Chunpu 李淳朴, DING, Jian 丁健, JIANG, Hualiang 蒋华良, LIU, Hong 柳红, GENG, Meiyu 耿美玉, ZHU, Wei 朱未, HUANG, Min 黄敏, CHEN, Xianjie 陈先杰, LIU, Hongchun 刘红椿, HE, Yulong 何玉龙, LI, Chunpu 李淳朴, DING, Jian 丁健, JIANG, Hualiang 蒋华良, CHEN, Kaixian 陈凯先] 555 Zu Chong Zhi Road 中国上海市浦东张江祖冲之路555号, Shanghai 201203Zhang Jiang, PudongShanghai 201203 The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular relates to a compound of general formula I as multi-targeted receptor tyrosine kinase inhibitors, such as EGFR, Her2, VEGFR and FGFR, and enantiomers, diastereoisomers, racemes and mixtures thereof, or pharmaceutical salt thereof, preparation method thereof, pharmaceutical composition comprising the compound, and the use thereof. The present invention relates to the field of pharmaceutical chemistry and pharmacotherapeutics, and in particular relates to a compound of general formula I as multi-targeted receptor tyrosine kinase inhibitors, such as EGFR, Her2, VEGFR and FGFR, and enantiomers, diastereoisomers, racemes and mixtures thereof, or pharmaceutical salt thereof, preparation method thereof, pharmaceutical composition comprising the compound, and the use thereof.

[FAN, Pingyan 樊平燕, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, ZHANG, Hongchun 张洪春, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, ZHANG, Hongchun 张洪春, LIU, Wei 刘伟, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, ZHANG, Hongchun 张洪春, LIU, Wei 刘伟, SUN, Liying 孙立赢, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, ZHANG, Hongchun 张洪春, LIU, Wei 刘伟, SUN, Liying 孙立赢, WANG, Hongxin 王洪鑫, FAN, Pingyan 樊平燕, SUN, Jidong 孙吉栋, MA, Zhaoyun 马兆云, ZHANG, Hongchun 张洪春, LIU, Wei 刘伟, SUN, Liying 孙立赢, WANG, Hongxin 王洪鑫, SHEN, Xingpei 申兴沛] No. 586 Lanzhoudong Road, Jiaozhou 中国山东省青岛市胶州市兰州东路586号, Shandong 266300Qingdao, Shandong 266300;Room 309B, 3rd Floor, Innovation and Technology 中国广东省东莞市松山湖高新技术产业开发区创新科技园1号楼3楼309B室, Guangdong 523000No.1 Building, High-Tech Industrial Development Zone, Song Shan LakeDongguan, Guangdong 523000;CIMC R&D Center No.2 Gangwan Avenue, Shekou Industrial Zone 中国广东省深圳市蛇口工业区港湾大道2号中集集团研发中心大楼, Guangdong 518067Shenzhen, Guangdong 518067 A container with a built-in oil tank comprises a cold machine and the oil tank in communication with the cold machine. The container with a built-in oil tank is characterized in that: a heat-preservation separation chamber is disposed in the container with a built-in oil tank, the oil tank is disposed in the heat-preservation separation chamber, the heat-preservation separation chamber is formed by multiple heat-preservation walls in a surrounding manner, a heat-preservation device is disposed on the heat-preservation separation chamber, and the heat-preservation walls comprise inner heat-preservation walls and outer heat-preservation walls disposed opposite to the inner heat-preservation walls. According to the container with a built-in oil tank in the present invention, the oil tank is disposed in the heat-preservation separation chamber, it is ensured that fuel oil in the oil tank is not solidified, and it is ensured that the cold machine can normally work under extreme conditions, more economical diesel oil can be used, operation costs are effectively reduced, and damage to the oil tank due to a collision can be effectively prevented.

[Wenlian LIU, Xianwei GONG, Fei DING, Guo TANG, Yunhui WU, Jun LIU, SuGang SUI, Jiansen WU, Ying BAI, Ting ZHENG, Zongming XU, Bin LEI, Hongchun PAN, Xufeng WANG, Tian ZHANG, Hanhua XU, Xiong WANG] CN Kunming A high-efficiency particle analysis method includes the following steps: taking representative air-dried samples and measuring a moisture content; boiling, sieving, weighing and adding a dispersant; conducting a particle analysis test; reading four readings of 1st to 59th and 60th to 90th samples; and drawing a particle size distribution curve showing the relationship between the particle size and the percentage of below a certain diameter. According to the method, a time difference is used to change the measurement mode, and the four readings of the 59th and 90th samples are read in a cycling manner; and a novel test method is provided on the premise of ensuring quality, thus greatly improving the efficiency of a particle analysis test and meeting production requirements.

[LIU, Wenlian 刘文连, GONG, Xianwei 龚宪伟, DING, Fei 丁飞, TANG, Guo 唐果, WU, Yunhui 吴云辉, LIU, Jun 刘军, SUI, SuGang 眭素刚, WU, Jiansen 吴建森, BAI, Ying 白莹, ZHENG, Ting 郑庭, XU, Zongming 徐宗明, LEI, Bin 雷斌, PAN, Hongchun 潘红春, WANG, Xufeng 王旭峰, ZHANG, Tian 张田, XU, Hanhua 许汉华, WANG, Xiong 王雄] No.1, Dongfeng Lane, Dongfeng East Road 中国云南省昆明市东风东路东风巷1号, Yunnan 650051Kunming, Yunnan 650051 A high-efficiency particle analysis method, the method comprising the following procedures: taking representative air-dried samples, measuring the moisture content thereof, boiling same, sieving same, weighing same and adding a dispersant, subjecting same to a particle analysis test, taking four readings of 1-59 and 60-90 samples, drawing a distribution curve of particle sizes and particle sizes smaller than a certain diameter percentage, etc. The metering mode is changed by utilizing the time difference, four readings of 59 and 90 samples are repeatedly and circularly realized, and a brand-new test method is provided on the premise of ensuring the quality thereof, such that the particle analysis test efficiency is greatly improved, and the production requirements are met.

[JIN, Lun 金伦, LIU, Fanfen 刘范芬, YUAN, Dingding 苑丁丁, LIU, Qingsong 刘青松, FU, Xing 付行, ZENG, Hongchun 曾红春] No. 68 Jingnan Avenue, Duodao District 中国湖北省荆门市荆门高新区·掇刀区荆南大道68号 448000Jingmen High-tech ZoneJingmen, Hubei 448000 A positive electrode sheet, and a preparation method for the positive electrode sheet. The positive electrode sheet comprises a positive electrode current collector and a positive electrode active material layer arranged on the surface of at least one side of the positive electrode current collector, wherein the positive electrode active material layer comprises a dispersion aid, lithium iron phosphate, electrically conductive carbon black and carbon nanotubes. The materials in the positive electrode active material layer satisfy the relational expression: 30≤(B1×C1+B2×C2+B3×C3)/A×0.01≤500, where A is the mass ratio of the dispersion aid in the positive electrode active material layer, B1 is the specific surface area of lithium iron phosphate, C1 is the mass ratio of lithium iron phosphate in the positive electrode active material layer, B2 is the specific surface area of the electrically conductive carbon black, C2 is the mass ratio of the electrically conductive carbon black in the positive electrode active material layer, B3 is the specific surface area of the carbon nanotubes, and C3 is the mass ratio of the carbon nanotubes in the positive electrode active material layer. By rationally matching the specific surface areas of lithium iron phosphate, the carbon black and the carbon nanotubes with the addition amounts of lithium iron phosphate, the carbon black, the carbon nanotubes and the dispersion aid in the positive electrode active material layer, the good distribution of a binder can be ensured in the positive electrode active material layer while a good electrically conductive network is formed, the stripping force of the positive electrode active material layer is improved, and the electrical resistance of the positive electrode active material layer is reduced, thereby reducing the DCR internal resistance of a battery and improving the rate capacity thereof.

[XIA, Lin, GENG, Meiyu, YE, Yan, DING, Jian, ZHANG, Qiong, SHEN, Aijun, HUANG, Ying, LIU, Hongchun, YANG, Haoran, AI, Jing, ZHANG, Minmin] Room 208, Section 103, Building 6 No. 421 Newton Rd. China (Shanghai) Pilot Free Trade Zone, Shanghai 201203, CN The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

[LIU, Hong 刘红, PAN, Hongchun 潘红春] 20-1, No.8, Huayu Mingdu Community, Shiqiaopu, Jiulongpo District 中国重庆市九龙坡区石桥铺华宇名都城小区8号20-1, Chongqing 400039Chongqing 400039 A solvent system capable of effectively dissolving ornidazole or levornidazole, and an application thereof. ornidazole or levornidazole is an active ingredient, and the solvent system is a mixed short chain polyethylene glycol and propylene glycol organic solvent; the short-chain polyethylene glycol is preferably polyethylene glycol 300 and/or polyethylene glycol 400. The solvent system can be used in the preparation of an injection fluid for ornidazole or an injection fluid for levornidazole. The ornidazole injection fluid or the levornidazole injection fluid have advantageous qualities such as being simpler to prescribe and safer to produce, the prepared products being more stable, not easily crystallizing at low temperatures, less solvent being needed, impurity (particularly genotoxic impurities) content being lower, phlebitis incidence being low, being without low pH infusion irritation, and being more suitable for use by a disulfiram reaction-sensitive patient, ensuring greater safety in clinical medication and better patient medication adherence. A solvent system capable of effectively dissolving ornidazole or levor

[Yangyang Yue, Xiaoping Song, Chengpeng Fu, Jian Li, Qinlian Bu, Hongchun Xu, Wuping Zhang, Chenggang Liu] CN Wuhan City, Hubei Disclosed are a dual-carrier integrated optical device and a photoelectric module. The optical device comprises: an encapsulation unit, and a ceramic substrate and two independent carrier assemblies arranged in the encapsulation unit. Every carrier assembly comprises a DWDM active chip arranged on the first heat sink, a first heat sink arranged on the independent control element, and an independent control element for adjusting the temperature of the DWDM active chip to adjust an output wavelength of the DWDM active chip. The DWDM active chip and the independent control element are respectively connected to the ceramic substrate. According to the characteristic that the wavelength of the active chip will shift with the temperature, an output laser wavelength of each active chip is independently controlled by means of the independent control element, which achieves higher wavelength stability and can realize optical signal transmission at different rates.

[YUAN, Shuguang 袁曙光, LI, Hongchang 李红昌, CHEN, Xianchong 陈显翀, LI, Hongchun 李红春, CUI, Wenqiang 崔文强, ZOU, Rongfeng 邹荣峰, LIU, Ke 刘科] 1068, Xueyuan Avenue, Shenzhen University Town, 中国广东省深圳市南山区深圳大学城学苑大道1068号, Guangdong 518055Nanshan DistrictShenzhen, Guangdong 518055 Disclosed is an application of sirtinol in the preparation of a drug for preventing and treating a coronavirus. Specifically disclosed is an application of sirtinol or a pharmaceutically acceptable salt, isotope, stereoisomer, mixture of stereoisomers, tautomer, ester, amide, or prodrug thereof in the preparation of a drug for preventing and treating a disease caused by a coronavirus. The coronavirus includes SARS-Cov-2, SARS-CoV, HCoV 229E, NL63, OC43, HKU1, and MERS-CoV. The disease caused by the coronavirus is pneumonia or a complication thereof caused by any of SARS-Cov-2, SARS-CoV, HCoV 229E, NL63, OC43, HKU1, or MERS-CoV. The invention confirms for the first time the inhibitory effect of sirtinol on SARS-Cov-2, which causes Covid-19, and has a low half maximal effective concentration, and thus has excellent potential.

[Liu Chen, Min Wang, Hongchun Wang] CN Shekou This Invention relates to a respiratory signal processing method, including the following steps: A. Obtain the respiratory physiological signals by means of a specific respiratory circuit, AD collects and obtains the respiratory digital signals and applies the data preprocessing to such signals; B. Convert frequency spectrum of the preprocessed respiratory signals and obtain the distribution of their frequency domain; C. Judge whether there is asphyxia in accordance with the properties of respiratory signal's physiological parameters; D. Introduce the physiological parameters of heart activities and analyze frequency spectrum distribution of respiratory signals and judge whether there is any interference from heart activities; E. Analyze the spectral energy envelop of respiratory waveform and find out the correct spectral peak, and then convert the frequency point corresponding to the spectral peak to the respiratory rate so as to obtain the value of current respiratory rate by integrating with the previous values of respiratory rate. The processing methods under this Invention can maximize the accuracy of results of respiratory rate and improve the stability of such result remarkably.