[Kane John M.(Cincinnati,OH), Maynard George D.(Westbrook,CT), Burkholder Timothy P.(Carmel,IN), Bratton Larry D.(Whitmore Lake,MI), Dalton Christopher R.(Mundelein,IL), Kudlacz Elizabeth M.(Groton,CT), Santiago Braulio(San Juan,PR)] The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): ##STR1## and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

[Maynard George D.(Westbrook,CT), Kane John M.(Cincinnati,OH), Dalton Christopher R.(Mundelein,IL), Santiago Braulio(San Juan,PR), Kudlacz Elizabeth M.(Groton,CT), Bratton Larry D.(Whitmore Lake,MI)] The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)?,4!diazepan-1-yl)-2-(aryl)butyl)b enzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

[Kane John M.(Cincinnati,OH), Maynard George D.(Westbrook,CT), Burkholder Timothy P.(Carmel,IN), Bratton Larry D.(Westminister,CO), Dalton Christopher R.(Mundelein,IL), Santiago Braulio(San Juan,PR), Kudlacz Elizabeth M.(Groton,CT)] The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers ##STR1## thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

[Burkholder Timothy P.(Carmel,IN), Bratton Larry D.(Whitmore Lake,MI), Kudlacz Elizabeth M.(Groton,CT), Maynard George P.(Westbrook,CT), Kane John M.(Cincinnati,OH), Santiago Braulio(San Juan,PR)] The present invention relates to novel substituted piperidine derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic diseases including: seasonal rhinitis, allergic rhinitis, and sinusitis.

[Burkholder Timothy P.(Carmel,IN), Maynard George D.(Westbrook,CT), Kudlacz Elizabeth M.(Groton,CT)] The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, coughs and bronchitis.

[Maynard George P.(Westbrook,CT), Kane John M.(Cincinnati,OH), Bratton Larry D.(Whitmore Lake,MI), Kudlacz Elizabeth M.(Groton,CT)] The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

[Maynard George P.(Westbrook,CT), Kane John M.(Cincinnati,OH), Bratton Larry D.(Whitmore Lake,MI), Kudlacz Elizabeth M.(Groton,CT)] The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

[Burkholder Timothy P.(Carmel,IN), Maynard George D.(Westbrook,CT), Kudlacz Elizabeth M.(Groton,CT)] The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.