[REDDY, Raja, K., REDDY, Raja, K., GLINKA, Tomasz, REDDY, Raja, K., GLINKA, Tomasz, TOTROV, Maxim, REDDY, Raja, K., GLINKA, Tomasz, TOTROV, Maxim, HECKER, Scott, REDDY, Raja, K., GLINKA, Tomasz, TOTROV, Maxim, HECKER, Scott, RODNY, Olga] 3033 Science Park Rd., Suite 200San Diego, CA 92121 Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.

[HECKER, Scott, HECKER, Scott, REDDY, Raja, K., HECKER, Scott, REDDY, Raja, K., GLINKA, Tomasz] 3033 Science Park Rd., Suite 200San Diego, CA 92121 Disclosed herein are antimicrobial compounds, compositions, pharmaceutical compositions, and the use and preparation thereof. Some embodiments relate to cyclic boronic acid ester derivatives and their use as therapeutic agents.

[TABASSUM NAZIA, HARINATH K, SREE DIVYA N, REDDY T RAMA, MASINA VENKATA RAJESH, RAMANA ATTILI VENKATA, RAO ANNALURI SREENIVASA, KUMAR RAJA BOINA RAJA, SHANMUKHI M, REDDY N CHANDRA SEKHAR] IN;IN;IN;IN;IN;IN;IN;IN;IN;IN DIMA-Dataset Discovery: DATASET DISCOVERY IN DATA INVESTIGATIVE USING MACHINE LEARNING AND Al-BASED PROGRAMMING Our invention "DIMA-Dataset Discovery" is an improved capability are described for design, mapping, developing, training, validating and deploying discovery virtual avatars, avatars embodying mathematical models must be used for document and large data repositories. For example: an avatar may be constructed by machine learning, Al-based Programming, method, processes, including by processing information related to what types of information analysis, Investigative find useful in large data sets. The invention an avatar must be deployed as an aid to human intuition in a wide range of analytical processes, such as related to international, national security, enterprise management, data management, query mapping (advertised, sales, marketing, product, promotions, placement, pricing, etc.). The invention also dispute resolution (including litigation), forensic analysis, criminal, administrative, civil and private investigations, scientific investigations, research and development, and a wide range of others. The data elements from the source data may be presented and tracking, scored, rated mapping or ranked based at least in part on the identifiers within the data cluster relating to the super-set topic. The mathematical model must be optimized based at least in part on a comparison of the scored data elements and upon reaching a threshold of optimization, accuracy, quality, or merit, the optimized mathematical model must be saved and stored as a computer-based discovery avatar parent. A second set of extracted data features must be extracted from the source data that share a second attribute that is related to both the super-set topic and a subset topic. Dr. M. Shanmukhi (Professor) NaziaTabassum (Assistant Professor) Dr. Raja boina Raja Kumar (Associate Professor) Dr. Attili Venkata Ramana (Associate Professor) Dr. Annaluri Sreenivasa Rao (Assistant Professor) N. Sree Divya (Assistant Professor) K. Harinath (Assistant Professor) Dr. Rama Reddy T (Professor) Dr. Venkata Rajesh Masina (Associate Professor) Dr. N Chandra Sekhar Reddy (Professor & Head) TOTAL NO OF SHEET: 05 NO OF FIG.:05 FEATURE YES TEST DOCUMENTS TOI EXTRACTION AA MST OPI INGEST10N 109 ECTORZATONNO -------- -------- CUSTR Q EUEUSER FEEDBACK Ila DETERMINE NEW EXPLOIT _ M LABELS J APPLY TOCA ? ~~INCOMING 4 TANG 112 DOCUMENTS USER EXPERIENCE STOP114 F11 Enrich using .. .... DBpedia FIG. 1: IS ASIMPLIFIED DIAGRAM OF ACURIOSITY ENGINE METHOD AND SYSTEM FOR THE CREATION AND TRAINING OF DISCOVERY AVATARS.

[REDDY DUNDATI KARUNAKAR, MOHAN ASHWALA, SHASHIDHAR K, PRASAD C HARI, LAVANYA K, LODHI AMAIRULLAH KHAN, MADHAVI B, KHAN MAZHER SARFARAZ, R PRIYADARSINI, SHAVALI T K SHAIK, AHAMAD SHAHANAWAJ, MEHANOOR SYEDA HUSNA, RAVINDER O, QASEEM MOHAMMAD SANAULLAH, RAJU K, SUSEELA K, CHEELA RAJA RAO, BEGUM SYEDA FARHATH] SA;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN;IN UTILIZATION OF INTERNET OF THINGS TO OPTIMIZE THE HUMAN TASK IN AN INDUSTRY 4.0 CONTEXT The Industrial Internet (IOT) is used to collect large amount of data (data-rich) , aggregated and shared in a meaningful way. Patent goal is to increase the automation level at domestic and commercial levels. In the Industrial Internet of Things, data is crucial as well and this causes a change in the human tasks in an Industry 4.0 context whereby automation leads to a decrease of specific types of work but at the same time requires new skillsets. The goal of the Industrial Internet of Things is also not to fully replace human work, its goal is to enhance and optimize it by creating new revenue streams and business models with a big role for data analysis. Keywords: Industrial IOT, IoT, Block Chain, Industry 4.0 Figures A) Traditional Cloud-loT Model B) Edge-loT Model C) 3-tier loT Model lou Coud :oud _ _I Edge Edge z Sensing Actuating Sensing Actuating Sensing Actuating Process Process Process Process Process Process Sensors Actuators Sensors Actuators Sensors Actuators jSLocal Edges Fig 1. loT frameworks

[Reddy, K. Raja, Stebbins, Jeff, Boyer, Serge, H., Erion, Mark, D., Hecker, Scott, J., Raffaele, Nicholas, Brian, Bookser, Brett, C., Reddy, Mali, Venkat] 11119 North Torrey Pines Road, Suite 200, La Jolla, CA 92037, US The invention pertains to use of DGAT-1 inhibitors to treat and/or prevent overweight, obesity and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease. Compounds and compositions suitable for use in the disclosed methods are also provided.

[REDDY, K., Raja, STEBBINS, Jeff, BOYER, Serge, H., ERION, Mark, D., HECKER, Scott, J., RAFFAELE, Nicholas, Brian, BOOKSER, Brett, C., REDDY, Mali, Venkat] 11085 North Torrey Pines Road Suite 300, La Jolla, CA 92037, US

[DANG QUN, ERION MARK D, REDDY M RAMI, ROBINSION EDWARD D, KASIBHATLA SRINIVAS RAO, REDDY K RAJA] Novel purine compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described.whereinA is selected from the group consisting of -NR82, -NHSO2R3, -OR5, -SR5, halo, lower alkyl, -CON(R4)2, guanidino, amidino, -H, and perhaloalkyl;E is selected from the group consisting of -H, halo, lower alkylthio, lower perhaloalkyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, -CN, and -NR72;X is selected from the group consisting of -alk-NR-, alkylene, alkenylene, alkynylene, arylene, heteroarylene, -alk-NR-alk-, -alk-O-alk-, -alk-S-alk-, -alk-S-, alicyclicene, heteroalicyclicene, 1,1-dihaloalkylene, -C(O)-alk-, -NR-C(O)-NR\'-, -alk-NR-C(O)-, -alk-C(O)-NR-, -Ar-alk-, and -alk-Ar-, all optionally substituted, wherein each R and R\' is independently selected from -H and lower alkyl, and wherein each "alk" and "Ar" is an independently selected alkylene or arylene, respectively;Y is selected from the group consisting of -H, alkyl, alkenyl, alkynyl, aryl, alicyclic, heteroalicyclic, aralkyl, aryloxyalkyl, alkoxyalkyl, -C(O)R3, -S(O)2R3, -C(O)-OR3, -CONHR3, -NR22, and -OR3, all except H are optionally substituted; andpharmaceutically acceptable prodrugs and salts thereof.

[GOMEZ-GALENO JORGE E, REDDY RAJA K, VAN POELJE PAUL D, LEMUS ROBERT HUERTA, NGUYEN THANH HUU, GROTE MATTHEW P, DANG QUN, HECKER SCOTT J, MALI VENKAT REDDY, CHEN MINGWEI, SUN ZHILI, BOYER SERGE HENRI, LI HAIQING, CRAIGO WILLIAM]

[CHEN MINGWEI, CRAIGO WILLIAM, GOMEZ-GALENO JORGE E, REDDY RAJA K, VAN POELJE PAUL D, LEMUS ROBERT HUERTA, NGUYEN THANH HUU, GROTE MATTHEW P, DANG QUN, HECKER SCOTT J, MALI VENKAT REDDY, SUN ZHILI, BOYER SERGE HENRI, LI HAIQING] US

[KASIBHATLA SRINIVAS RAO, REDDY K RAJA, ERION MARK D, REDDY M RAMI, DANG QUN, AGARWAL ATUL] US