[ZHU XIANCHAO, CHEN HUAGEN, XIONG XISHUANG, LI YING, WANG JUANJUAN, LIU CHANG, XIA QINGFENG, MAO YIZHI, WANG ZHU, SHEN ENHUA] CN;CN

[ZHU, Xianchao 祝先潮, CHEN, Huagen 陈华根, XIONG, Xishuang 熊细双, LIU, Chang 刘畅, LI, Ying 李颖, XIA, Qingfeng 夏清风, HE, Ping 何平, WANG, Juanjuan 王娟娟, HUANG, Xiaomin 黄小敏] ROOM B201, BUILDING 1, 1976 MIDDLE GAOKE ROAD 中国上海市浦东新区高科中路1976号1幢B201室, Shanghai 201203Pudong New Area, Shanghai 201203;2ND FLOOR, BUILDING 19 (D1), 356 ZHENGBO ROAD 中国上海市奉贤区正博路356号19幢(D1)2层, Shanghai 201413Fengxian District, Shanghai 201413 The present invention relates to a polyvalent pneumococcal polysaccharide protein conjugate and immunogenicity thereof, and specifically provides an immunogenic composition containing capsular polysaccharides of streptococcus pneumoniae from different serotypes, and a carrier, the serotypes at least comprising 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F. The immunogenic composition can improve the immunogenicity of polysaccharides of different serotypes, and may prevent invasive infection caused by pneumococci of various different serotypes. The present invention relates to a polyvalent pneumococcal polysaccharide protein conjugate and immunogenicity thereof, and specifically provides an immunogenic composition containing capsular polysaccharides of streptococcus pneumoniae from different serotypes, and a carrier, the serotypes at least comprising 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F. The immunogenic composition can improve the immunogenicity of polysaccharides of different serotypes, and may prevent invasive infection caused by pneumococci of various different serotypes.

[ZHU XIANCHAO, CHEN HUAGEN, XIONG XISHUANG, LI YING, WANG JUANJUAN, LIU CHANG, XIA QINGFENG, MAO YIZHI, WANG ZHU, SHEN ENHUA] ; Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

[ZHU XIANCHAO, CHEN HUAGEN, XIONG XISHUANG, LI YING, WANG JUANJUAN, LIU CHANG, XIA QINGFENG, MAO YIZHI, WANG ZHU, SHEN ENHUA] CN;CN Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

[ZHU, Xianchao, CHEN, Huagen, XIONG, Xishuang, LI, Ying, WANG, Juanjuan, LIU, Chang, XIA, Qingfeng, MAO, Yizhi, WANG, Zhu, SHEN, Enhua] Room B201, Building 1 1976 Middle Gaoke Road Pudong New District, Shanghai 201203, CN Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

[ZHU XIANCHAO, CHEN HUAGEN, XIONG XISHUANG, LIU CHANG, LI YING, XIA QINGFENG, HE PING, WANG JUANJUAN, HUANG XIAOMIN] CN;CN

[ZHU XIANCHAO, CHEN HUAGEN, XIONG XISHUANG, LI YING, WANG JUANJUAN, LIU CHANG, XIA QINGFENG, MAO YIZHI, WANG ZHU, SHEN ENHUA] CN;CN Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

[ZHU, Xianchao 祝先潮, CHEN, Huagen 陈华根, XIONG, Xishuang 熊细双, LI, Ying 李颖, WANG, Juanjuan 王娟娟, LIU, Chang 刘畅, XIA, Qingfeng 夏清风, MAO, Yizhi 毛意芝, WANG, Zhu 王著, SHEN, Enhua 谌恩华] Room B201, Building 1, 1976 Middle Gaoke Road, Pudong New District 中国上海市浦东新区高科中路1976号1幢B201室, Shanghai 201203Shanghai 201203 Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.

[ZHU, Xianchao, CHEN, Huagen, XIONG, Xishuang, LIU, Chang, LI, Ying, XIA, Qingfeng, HE, Ping, WANG, Juanjuan, HUANG, Xiaomin] 5th floor, Building 1, 367 Shengrong Road, Pudong New District, Shanghai 201210, CN The present invention relates to a polyvalent pneumococcal polysaccharide protein conjugate and immunogenicity thereof, and specifically provides an immunogenic composition containing capsular polysaccharides of streptococcus pneumoniae from different serotypes, and a carrier, the serotypes at least comprising 2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20, 22F and 33F. The immunogenic composition can improve the immunogenicity of polysaccharides of different serotypes, and may prevent invasive infection caused by pneumococci of various different serotypes.

[Xianchao ZHU, Huagen CHEN, Xishuang XIONG, Ying LI, Juanjuan WANG, Chang LIU, Qingfeng XIA, Yizhi MAO, Zhu WANG, Enhua SHEN] CN Shanghai Provided is a tetanus toxin protein variant, the tetanus toxin protein variant comprising a C fragment of the tetanus toxin protein and a partial fragment of a translocation region of the tetanus toxin protein. Further provided is a proteoglycan conjugate, the proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein. Also provided is a method for improving immunogenicity, the method comprising the following steps: providing a proteoglycan conjugate comprising a polysaccharide from Streptococcus pneumoniae and a truncated tetanus toxin protein.