[ZHAO, Libo 赵立波, KONG, Guanyi 孔关义, LI, Hongyan 李鸿艳, GUAN, Hongtao 关宏涛, WANG, Jianwu 王建武, ZHAO, Hang 赵航, YOU, Zhicheng 游栉铖, LIU, Da 刘达, LIN, Zhongqing 林中青, LI, Zhi 李志, CHEN, Jing 陈静] {Room 108, Building 1, China Resources Life Science Park, Baoshen South Street 中国北京市大兴区宝参南街华润生命科学园1号楼108, Beijing 102609Daxing District, Beijing 102609;CN CN(CN)(CN)} The present invention provides an engineered extracellular vesicle, a pharmaceutical composition containing the engineered extracellular vesicle and a use thereof, and further provides a method for constructing the engineered extracellular vesicle. The engineered extracellular vesicle can be used for drug delivery, enrichment of target proteins in extracellular vesicles, or display of target proteins. The present invention provides an engineered extracellular vesicle, a pharmaceutical composition containing the engineered extracellular vesicle and a use thereof, and further provides a method for constructing the engineered extracellular vesicle. The engineered extracellular vesicle can be used for drug delivery, enrichment of target proteins in extracellular vesicles, or display of target proteins.

[WANG, Xiangmin 王祥敏, LIANG, Zefeng 梁泽锋, YAN, Qiang 颜强, ZHANG, Qingyang 张庆扬, YAO, Chuangmu 姚创沐, WANG, Ge 王戈, DING, Jiayi 丁佳艺, CHEN, Zhenhong 陈震鸿, ZHAO, Meng 赵猛, BAI, Qian 白乾, ZHAO, Hang 赵航, ZHU, Wenfeng 祝文锋, SUN, Keliang 孙科亮, LIN, Qiaoying 林巧英, CHEN, Dandan 陈丹丹, LIN, Xiumin 林秀敏, ZOU, Ming 邹明, CHEN, Jiamin 陈家敏, ZHANG, Huawei 张华薇, CHEN, Zhihao 陈志浩, MO, Yurun 莫雨润, ZHONG, Jiawen 钟伽文, YUAN, Mu 苑木, ZOU, Fu 邹夫] 35/F, Tencent Building 中国广东省深圳市南山区高新区科技中一路腾讯大厦35层, Guangdong 518057Kejizhongyi Road, Midwest District of Hi-tech park Nanshan DistrictShenzhen, Guangdong 518057 A method and device for image search, a computer apparatus, and a storage medium. The method comprises: displaying an image selection page of an instant messaging client (101); determining, on the basis of an operation performed by a user with respect to the image selection page, an input image for a search operation (102); presetting multiple image similarity dimensions according to the level of similarity between two chat session interactive images (103); searching on the basis of the multiple image similarity dimensions to obtain one or more output images similar to the input image (104), wherein each output image is similar to the input image in at least one image similarity dimension; and generating a search result list according to the one or more output images, and displaying same (105).

[HU, Qingwen 胡青文, ZHAO, Hang 赵航, LIN, Gaojie 林高杰, DONG, Dengke 董登科] Room B-0035, 2/F, No. 3 Building, No. 30, Shixing Road, Shijingshan District 中国北京市石景山区实兴大街30号院3号楼2层B-0035房间, Beijing 100041Beijing 100041 Disclosed are a virtual object display method and apparatus, an electronic device, and a readable medium. The method comprises: recognizing a trigger gesture in hand images according to three-dimensional coordinates of a hand key point, the hand images comprising a first hand image having at least two continuous frames of the hand key point that are relatively static and at least one frame of a second hand image, the hand key point in the second hand image moving relative to the first hand image, and a gesture of the hand of at least one of the first hand image and the second hand image being the trigger gesture; in response to the trigger gesture, determining a throwing parameter according to the hand images; simulating a trajectory of a thrown virtual object according to the throwing parameter and displaying the trajectory in an augmented reality scene. Disclosed are a virtual object display method and apparatus, an electronic device, and a

[HUANG, Yanshan 黄岩山, NI, Sheng 倪晟, XIA, Jinqiang 夏金强, ZHU, Mingyue 朱明月, FANG, Chen 方晨, SUN, Peng 孙鹏, ZHAO, Hang 赵航, XU, Bingyong 徐兵勇] Floor 2, Building 3, Hexiang Science And Technology Center, Phase 3, Medicine Port Town, Qiantang New District 中国浙江省杭州市钱塘新区医药港小镇三期和享科技中心3幢2楼, Zhejiang 310018Hangzhou, Zhejiang 310018;Room 201, Building 4, No. 101, No. 1 Street, Qiantang New District 中国浙江省杭州市钱塘新区1号大街101号4幢201室, Zhejiang 310018Hangzhou, Zhejiang 310018 Provided is a long-acting glucagon derivative, the amino acid sequence thereof comprising the sequence shown in SEQ ID NO: 9. Animal experiments show that, when compared to the similar fatty acid-modified GLP-1R single agonist Semaglutide (J Med. Chem. 2015, 58(18):7370-80), the long-acting glucagon derivative has stronger glucose tolerance and weight reduction activity in mice, and can last for a longer period of time.

[ZHAO, Hang 赵航] Room 01, Level 9, Sohu.com Internet Plaza 中国北京市海淀区中关村东路1号院9号楼搜狐网络大厦9层01房间, Beijing 100084No.9 Building, No. 1 Park Zhongguancun East Road, Haidian DistrictBeijing 100084 A data processing method and device. The method comprises: determining a search keyword according to a search statement inputted by a user (S101), and determining a first graph entity library corresponding to a category to which the search keyword belongs (S102); according to an association relationship among multiple categories of graph entity libraries, determining the category of a graph entity library associated with the first graph entity library, and constructing a first set, the first set comprising at least one graph entity library having an association relationship with the first graph entity library, and the association relationship among the graph entity libraries being constructed according to search requirements of the user (S103); and after the first set is constructed, using the search keyword as a center to display the graph entity libraries comprised in the first set (S104). The first set can reflect the search requirements of the search statement and guide the user to further trigger a search behavior on the basis of the search requirements of the user; and the method allows for providing a search result meeting the user requirements to the user. A data processing method and device. The method comprises: determining a search keyword according to a search statement inputted by a user (S101), and determining a first graph entity library corresponding to a category to which the search keyword belongs (S102); according to an association relationship among multiple categories of graph entity libraries, determining the category of a graph entity library associated with the first graph entity library, and constructing a first set, the first set comprising at least one graph entity library having an association relationship with the first graph entity library, and the association relationship among the graph entity libraries being constructed according to search requirements of the user (S103); and after the first set is constructed, using the search keyword as a center to display the graph entity libraries comprised in the first set (S104). The first set can reflect the search requirements of the search statement and guide the user to further trigger a search behavior on the basis of the search requirements of the user; and the method allows for providing a search result meeting the user requirements to the user.

[NI, Shen 倪晟, WANG, Zhenhuan 王振环, XIA, Jinqiang 夏金强, LIAO, Zhixiong 廖志雄, ZHAO, Hang 赵航, XU, Binyong 徐兵勇, ZHOU, Liang 周亮, CHEN, Hongxiang 陈鸿翔] No. 101, No. 1 Street, Qiantang 中国浙江省杭州市钱塘区1号大街101, Zhejiang 310000Hangzhou, Zhejiang 310000;Room 409, Building 2, No. 400, Fucheng Road, Qiantang 中国浙江省杭州市钱塘区浙江省杭州市钱塘区福城路400号2幢409室, Zhejiang 310000Hangzhou, Zhejiang 310000 An abiraterone acetate soft capsule and a preparation method therefor. The capsule is composed of contents and a capsule shell. The contents comprise abiraterone acetate, caprylic-acid capric-acid mono- and diglycerides, Tween 80, Span 80, and butyl hydroxy anisol; the capsule shell is made of a soft capsule material, the composition of the capsule shell comprises gelatin, water, glycerol, and a sorbitol sorbitan solution, and the proportion of the components is 1:0.74:0.35:0.35. After the abiraterone acetate soft capsule is orally taken in an empty stomach, the oral bioavailability is increased to 12.5 times compared with an original drug Zytiga, the variability among individuals is low, and the phenomenon that the exposure amount of the abiraterone is obviously increased due to administration of the original drug of Zytiga after meal is eliminated.

[QIE, Shengkai 郄胜凯, XU, Quanliang 徐全亮, ZHANG, Bingyao 张炳瑶, ZHANG, Qingfeng 张清风, ZHAO, Hang 赵航, LI, Guoquan 李国权, FU, Zhongkai 付中锴] 101, Floors 1-4, Building No. 4, Yard 9, Dijin Road, 中国北京市海淀区地锦路9号院4号楼-1至4层101, Beijing 100095Haidian District, Beijing 100095 The present application discloses a road underground structural defect detection method, a medium, and a system. The method comprises: acquiring a road sample set, samples of the road sample set comprising: a road longitudinal section, a cross section waveform image, and first feature data acquired by three-dimensional ground penetrating radar; training a convolutional neural network by means of the road sample set, the convolutional neural network comprising: two independent convolutional modules, and a fusion layer, a first fully-connected layer, a second fully-connected layer, and a classification layer sequentially connected to the two convolutional modules, each convolutional module comprising: a first convolutional unit, a second convolutional unit, a third convolutional unit, a fourth convolutional unit, and a fifth convolutional unit that are sequentially connected; and inputting acquired measured information of a road into the trained convolutional neural network, so that the convolutional neural network outputs a category of an underground structural defect corresponding to the measured information, the measured information comprising: a road longitudinal section, a cross section waveform image, and second feature data acquired by the three-dimensional ground penetrating radar. The present application can improve the accuracy of structural defect category recognition.

[CHAO, Ruochen 巢若尘, XU, Zhihua 许志华, CAO, Guoxin 曹国新, ZHANG, Le 张乐, CHEN, Manman 陈蔓蔓, ZHAO, Hang 赵航] No. 39 Caohu Avenue, Xiangcheng Economic Development Zone 中国江苏省苏州市相城经济开发区漕湖大道39号, Jiangsu 215100Suzhou, Jiangsu 215100;B26-28F. Midea Headquarter Building, No. 6 Midea Avenue, Beijiao, Shunde 中国广东省佛山市顺德区北滘镇美的大道6号美的总部大楼B区26-28楼, Guangdong 528311Foshan, Guangdong 528311 A floor brush assembly (100) and a cleaning device, the floor brush assembly (100) comprising: a housing (110); a rolling brush (130) rotatably disposed on the housing (110); and squeezing rollers (140) disposed on the housing (110) via bearings (150), wherein the circumferential sides of the squeezing rollers (140) are in contact with the circumferential side of the rolling brush (130), and the squeezing rollers (140) squeeze the rolling brush (130); when the rolling brush (130) rotates, the squeezing rollers (140) rotate along with the rolling brush (130).

[ZHAO, Hang 赵航, LI, Wuyang 李武阳] NO.36 PHOENIX ROAD, JIANGNING ECONOMIC AND TECHNOLOGY DEVELOPMENT ZONE 中国江苏省南京市江宁经济技术开发区菲尼克斯路36号, Jiangsu 211100Nanjing, Jiangsu 211100 Disclosed in the present application are a control method for a programmable logic controller, and a programmable logic controller. The control method comprises: by means of a multi-language programming interface, receiving an interface invoking application which is sent by a high-level language program unit; and the multi-language programming interface applying for the invoking of a remote control interface on the basis of the interface invoking application, and controlling, by means of the remote control interface, a programmable logic controller to execute a corresponding programming action. In the present application, by means of configuring a multi-language programming interface, an application instruction which is sent by means of a preset programming language can be received, and on the basis of the application instruction and by means of a remote control interface, a programmable logic controller is controlled to act, thereby solving the technical problems in the prior art of a programmable logic controller not supporting the use of a high-level programming language, resulting in an increase in the learning costs of a user and a decrease in the applicability of the programmable logic controller, such that the technical effects of improving the applicability of the programmable logic controller and reducing the learning costs of the user are achieved. Disclosed in the present application are a control method for a programmable logic controller, and a programmable logic controller. The control method comprises: by means of a multi-language programming interface, receiving an interface invoking application which is sent by a high-level language program unit; and the multi-language programming interface applying for the invoking of a remote control interface on the basis of the interface invoking application, and controlling, by means of the remote control interface, a programmable logic controller to execute a corresponding programming action. In the present application, by means of configuring a multi-language programming interface, an application instruction which is sent by means of a preset programming language can be received, and on the basis of the application instruction and by means of a remote control interface, a programmable logic

[ZHAO, Hang 赵航] Fourth Floor, One Capital Place, P.O. Box 847, George Town 开曼群岛大开曼资本大厦一座四层847号邮箱, Grand CaymanGrand Cayman Embodiments of the present application provide a method and apparatus for sending information, so as to resolve the problems of increase in the costs for information sending for a sender and waste of resources needed for information sending of the information sending method in the prior art. In the method, a server separately sends information to a user in a first sending mode and a second sending mode within a waiting time for sending information, and monitors within the waiting time whether the user has received and checked the information that is sent in the first sending mode and the second sending mode; if yes, the server does not utilize a mobile communication network to send information to the user; if not, the server utilizes a mobile communication network to send information to the user. By sending information in the method, a server is enabled to detect within a waiting time whether a user has checked the information that is sent by the server in a second sending mode, and not to utilize the mobile communication network to send information to the user after detecting that the user has checked the information. The present application is capable of effectively reducing costs for information sending and saving resources needed for information sending relative to the prior art. Embodiments of the present application provide a method and apparatus for sending information, so as to resolve the problems of increase in the costs for information sending for a sender and waste of resources needed for information sending of the information sending method in the prior art. In the method, a server separately sends information to a user in a first sending mode and a second sending mode within a waiting time for sending information, and monitors within the waiting time whether the user has received and checked the information that is sent in the first sending mode and the second sending mode; if yes, the server does not utilize a mobile communication network to send information to the user; if not, the server utilizes a mobile communication network to send information to the user. By sending information in the method, a server is enabled to detect within a waiting time whether a user has checked the information that is sent by the server in a second sending mode, and not to utilize the mobile communication network to send information to the user after detecting that the user has checked the information. The present application is capable of effectively reducing costs for information sending and saving resources needed for information sending relative to the prior art.