[YE, Hong 叶红, YE, Hong 叶红, LIU, Gang 刘钢, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, ZHONG, Wei 钟维, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, ZHONG, Wei 钟维, LI, Shaohua 李少华, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, ZHONG, Wei 钟维, LI, Shaohua 李少华, WU, Xunwei 巫循伟, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, ZHONG, Wei 钟维, LI, Shaohua 李少华, WU, Xunwei 巫循伟, WANG, Lichun 王利春, YE, Hong 叶红, LIU, Gang 刘钢, YU, Nan 郁楠, ZENG, Hong 曾宏, ZHAO, Mingliang 赵明亮, QING, Yan 卿燕, DENG, Hua 邓华, LI, Wenjia 李雯佳, LI, Donghong 李栋宏, SU, Donghai 苏东海, ZHONG, Wei 钟维, LI, Shaohua 李少华, WU, Xunwei 巫循伟, WANG, Lichun 王利春, WANG, Jingyi 王晶翼] No.666, Xinhua Avenue (Section 2) 中国四川省成都市温江区海峡两岸科技产业园新华大道二段666号, Sichuan 611138Hai Xia Industrial Park, Wenjiang DistrictChengdu, Sichuan 611138 The present invention relates to a novel compound of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same and an application thereof. Specifically, the present invention relates to a phosphamide derivative of 4'-thionucleoside, a preparation method therefor, a pharmaceutical composition comprising the same, a use thereof in the preparation of a medicine for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases, and a method of using the same for preventing or treating abnormal cell proliferation diseases (for example, tumors or cancers and related diseases) or virus infectious diseases.

[ARATA, Michelle, Denise, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, TRECO, Douglas, A., ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, TRECO, Douglas, A., WANG, Zhaolin, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, TRECO, Douglas, A., WANG, Zhaolin, YE, Ping, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, TRECO, Douglas, A., WANG, Zhaolin, YE, Ping, ZHENG, Hong, ARATA, Michelle, Denise, DHAMNASKAR, Ketki, Ashok, ELBAUM, Daniel, JOSEPHSON, Kristopher, LARSON, Kelley, Cronin, MA, Zhong, NIMS, Nathan, Ezekiel, RICARDO, Alonso, SEYB, Kathleen, TANG, Guo-Qing, TRECO, Douglas, A., WANG, Zhaolin, YE, Ping, ZHENG, Hong, PERLMUTTER, Sarah, Jacqueline] One Kendall SquareSuite B14301Cambridge, MA 02139 The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.

[WANG, Xiaoqian 王晓倩, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, YE, Xiaofei 叶晓飞, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, ZHONG, Guoxing 钟国兴, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, ZHONG, Guoxing 钟国兴, LI, Xue 李雪] Building No. 7, BIG Park, No. 21, Hongan 3rd Street 中国广东省深圳市盐田区洪安三街 21号华大综合园7栋7层-14层, Guangdong 518083Yantian DistrictShenzhen, Guangdong 518083 Disclosed are a primer for detecting colorectal cancer drug-related gene mutation, a detection method and an application. The primer of the present application comprises 25 specific primer sets and 1 general primer set. The specific primer sets comprise specific primers respectively for detecting 27 mutation sites of 15 colorectal cancer drug-related genes, and the general primer set comprises outer primers commonly used for amplified products of the 25 specific primer sets. The 25 specific primer sets are sequentially shown as Seq ID NO. 1 to Seq ID NO. 50, wherein Seq ID NO. 1 and Seq ID NO. 2 form one set, Seq ID NO. 3 and Seq ID NO. 4 form one set, and so on; and the sequences of the general primer set are shown as Seq ID NO. 51 and Seq ID NO. 52.

[KUANG, Ye 邝野, KUANG, Ye 邝野, LI, Ou 李鸥, KUANG, Ye 邝野, LI, Ou 李鸥, LU, Yiqiu 陆怡秋, KUANG, Ye 邝野, LI, Ou 李鸥, LU, Yiqiu 陆怡秋, JIAO, Weiqi 焦伟棋, KUANG, Ye 邝野, LI, Ou 李鸥, LU, Yiqiu 陆怡秋, JIAO, Weiqi 焦伟棋, ZHONG, Tao 钟涛] Han's Industrail Park, No. 128 Chong Qing Rd, Fu yong, Bao'an District 中国广东省深圳市福永重庆路128号大族激光工业园4栋, Guangdong 518103Shenzhen, Guangdong 518103 A sharp corner transition module, comprising: a module bottom casing (1), an LED PCB board (2) and an arc-shaped mask (3); the LED PCB board (2) is located in a space formed between the module bottom casing (1) and the arc-shaped mask (3); the module bottom casing (1) is provided with LED mounting points (11) therein; and the arc-shaped mask (3) is provided with holes adapted to the LEDs on the LED PCB board (2). The sharp corner transition module solves the problem of generating a non-display black line defect at the sharp corner when an integral display screen is formed from butting the sharp corners of two planar display screens, such that a non-planar display screen achieves a seamless joint with no display gap and no black line defect in full-screen display.

[TAO, Qingsheng, TAO, Qingsheng, ZHONG, Ye, TAO, Qingsheng, ZHONG, Ye, ZHOU, Yi] Weena 455NL-3013 AL Rotterdam;Unilever House, 100 Victoria EmbankmentLondon Greater London EC4Y 0DY;800 Sylvan Avenue AG West, S. WingEnglewood Cliffs, NJ New Jersey 07632 Disclosed is a composition comprising particle having average diameter of no greater than 3 microns; non-volatile silicone; and at least 30% of water by weight of the composition, wherein the weight ratio of the particle to the non-volatile silicone is at least 3:1.

[SHAO, Libin 邵利彬, SHAO, Libin 邵利彬, SHAO, Kang 邵康, SHAO, Libin 邵利彬, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, SHAO, Libin 邵利彬, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, SHAO, Libin 邵利彬, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, WANG, Hui 王惠, SHAO, Libin 邵利彬, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, WANG, Hui 王惠, AN, Na 安娜, SHAO, Libin 邵利彬, SHAO, Kang 邵康, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, WANG, Hui 王惠, AN, Na 安娜, ZHONG, Guoxing 钟国兴] Floor 7-14, Building No.7, BGI Park, No. 21 Hongan 3rd Street 中国广东省深圳市盐田区洪安三街21号华大综合园7栋7层-14层, Guangdong 518083Yantian DistrictShenzhen, Guangdong 518083 Disclosed are primers used for detecting related gene mutations of gastrointestinal stromal tumour medications and a detection method and use. The primers comprise a set of 24 specific primer pairs which detect 32 mutational sites of 14 related genes of gastrointestinal stromal tumour medications, respectively; and a set of one universal primer pair which is made up of outer primers commonly used for amplification products of the set of 24 specific primer pairs.

[SHAO, Libin 邵利彬, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, YE, Xiaofei 叶晓飞, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, YE, Xiaofei 叶晓飞, AN, Na 安娜, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, ZHONG, Guoxing 钟国兴] Floor 7-14, Building No.7, BGI Park, No. 21 Hong'an 3rd Street 中国广东省深圳市盐田区洪安三街21号华大综合园7栋7层-14层, Guangdong 518083Yantian DistrictShenzhen, Guangdong 518083 Disclosed are primers used for detecting related gene mutations of non-small-cell lung cancer medications and a detection method and use. The primers of the present application comprise a set of 41 specific primer pairs and a set of one universal primer pair, wherein the specific primer set is made up of specific primers for detecting 41 mutational sites of 12 related genes of non-small-cell lung cancer medications, respectively; and the universal primer set is made up of outer primers commonly used for amplification products of the set of 41 specific primer pairs.

[SHAO, Kang 邵康, SHAO, Kang 邵康, SHAO, Libin 邵利彬, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, AN, Na 安娜, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, SHAO, Kang 邵康, SHAO, Libin 邵利彬, WANG, Xiaoqian 王晓倩, YE, Xiaofei 叶晓飞, AN, Na 安娜, WANG, Hui 王惠, ZHONG, Guoxing 钟国兴] Floor 7th-14th, Building No.7, BGI Park, No.21 Hong'an 3rd Street, Yantian District 中国广东省深圳市盐田区洪安三街21号华大综合园7栋7层-14层, Guangdong 518083Shenzhen, Guangdong 518083 Disclosed are a qRT-PCR primer, probe, chip, kit, application and method for detecting a non-small cell lung cancer (NSCLC). The primer and probe comprise a sequence selected from SEQ ID NOs: 1-66, and can detect 22 subtypes of fusion genes, EML4-ALK, NMP1-ALK, CD74-ROS, SLC34A2-ROS, CDCC6-RET and KIF5B-RET.

[YE ZHONG-YI, YE MING-YING, YE YI-LAN] TW;TW;TW

[YE ZHONG-YI, YE MING-YING, YE YI-LAN] TW;TW;TW