in:(Zhen Zhen Chen)

NOVEL TRIAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF PCT/CN2016/076118
[YUAN, Daoyi 袁道义, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, GONG, Aishen 宫爱申, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, GONG, Aishen 宫爱申, XIANG, Zhixiang 向志祥, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, GONG, Aishen 宫爱申, XIANG, Zhixiang 向志祥, WANG, Mingxia 王明霞, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, GONG, Aishen 宫爱申, XIANG, Zhixiang 向志祥, WANG, Mingxia 王明霞, LIU, Guoqiang 刘国强, YUAN, Daoyi 袁道义, ZHAO, Xiong 赵雄, CHEN, Zhen 陈真, LI, Xuechao 李学超, PENG, Dan 彭丹, OU, Xingrong 欧兴蓉, CHENG, He 程鹤, LUO, Jie 罗杰, YAN, Pangke 严庞科, GONG, Aishen 宫爱申, XIANG, Zhixiang 向志祥, WANG, Mingxia 王明霞, LIU, Guoqiang 刘国强, WANG, Gengyu 王庚禹] ZHAO, Deyu 中国四川省成都市温江区海峡两岸科技产业开发园百利路136号赵德余, Sichuan 611130No.136 Beverley Road, Across the Taiwai Strait Technology Industry Development ParkWenjiang DistrictChengdu, Sichuan 611130;WANG Wei 中国广东省广州市广州高新技术产业开发区科学大道97号1321房王伟, Guangdong 510032Room 1321, No. 97, Guangzhou new and high tech Industrial Development ZoneGuangzhou, Guangdong 510032 Provided are a novel triazolopyrimidine derivative represented by formula II, crystal form and preparation method thereof, and use thereof in the preparation of medicine for resisting coagulation and thrombus, treating or preventing cerebral ischemia diseases, or improving sleep.
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2-PHENYLIMIDAZOLE DERIVATIVE CONTAINING PROPYNAMIDE GROUPS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF PCT/CN2016/083236
[FENG, Zhiqiang 冯志强, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, ZHOU, Wanqi 周婉琪, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, ZHOU, Wanqi 周婉琪, ZHEN, Ruonan 郑若男, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, ZHOU, Wanqi 周婉琪, ZHEN, Ruonan 郑若男, ZHEN, Yi 郑义, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, ZHOU, Wanqi 周婉琪, ZHEN, Ruonan 郑若男, ZHEN, Yi 郑义, ZHOU, Chuan 周川, FENG, Zhiqiang 冯志强, CHEN, Xiaoguang 陈晓光, LI, Yan 李燕, LIU, Yanjie 刘艳杰, JIN, Xiaofeng 金小锋, ZHOU, Wanqi 周婉琪, ZHEN, Ruonan 郑若男, ZHEN, Yi 郑义, ZHOU, Chuan 周川, LIU, Chunxia 刘春霞] ZHANG, Xubin 中国北京市西城区南纬路甲2号张徐斌, Beijing 100050No.A2, Nan Wei Road, Xicheng DistrictBeijing 100050 Disclosed are a 2-phenylimidazole derivative that contains propynamide groups and that is represented by formula I, a pharmaceutical salt thereof, a preparation method therefor, a composition containing the one or more compounds, and uses of the compounds in the preparation of drugs for preventing or treating tumor diseases.
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PF RAPID DATABASE CONSTRUCTION METHOD AND APPLICATION THEREFOR PCT/CN2014/087603
[LI, Jian 李剑, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHANG, Xiandong 张现东, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Wei 李尉, LI, Jian 李剑, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Wei 李尉, HUANG, Yile 黄奕乐] Floor 7 to 14, Building No. 7, BGI Park, No. 21 Hongan 3rd Street, Yantian District 中国广东省深圳市盐田区洪安三街21号华大综合园7栋7层-14层, Guangdong 518083Shenzhen, Guangdong 518083 A PF rapid database construction method and an application therefor. The PF rapid database construction method comprises the following steps: a first step of fragmenting genomic DNA so as to obtain DNA fragments; a second step of performing end repairing on the DNA fragments; a third step of adding P1 and BarcodeX adapters at the ends of the DNA fragments having undergone end repairing; a fourth step of performing library mixing according to the required yield of each library; a fifth step of performing nick translation on the mixed libraries; a sixth step of performing quality testing on the product having undergone nick translation.
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CNV ANALYSIS METHOD FOR CHROMOSOMES OF SINGLE-CELL AND DETECTION DEVICE PCT/CN2014/087604
[LI, Jian 李剑, LI, Jian 李剑, XIA, Yingying 夏滢颖, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, ZHANG, Xiandong 张现东, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Wei 李尉, LI, Jian 李剑, XIA, Yingying 夏滢颖, CHEN, Dayang 陈大洋, ZHEN, Heqiang 甄贺富, ZHANG, Caifen 张彩芬, ZHANG, Aiping 张爱萍, ZHANG, Xiandong 张现东, LIU, Saijun 刘赛军, LI, Wei 李尉, HUANG, Yile 黄奕乐] Floors 7 to14, Building No. 7, BGI Park, No. 21 Hongan 3rd Street, Yantian District 中国广东省深圳市盐田区洪安三街21号华大综合园7栋7层-14层, Guangdong 518083Shenzhen, Guangdong 518083 A CNV analysis method for chromosomes of a single-cell and a detection device, the CNV analysis method for chromosomes of a single-cell comprising the following steps: a first step of extracting effective data; a second step of performing sequence alignment on the extracted effective data then determining whether a Y chromosome is present; a third step of dividing the sequences having undergone sequence alignment into windows then performing GC-content correction; a fourth step of performing breakpoint screening on the data having undergone GC-content correction; a fifth step of filtering the data having undergone breakpoint screening for data satisfying a determining condition and performing visualisation.
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DRIVING METHOD, DRIVING CIRCUIT AND DISPLAY APPARATUS PCT/CN2015/087007
[DENG, Liguang, DENG, Liguang, CHEN, Zhen, DENG, Liguang, CHEN, Zhen, KIM, Hyungkyu, DENG, Liguang, CHEN, Zhen, KIM, Hyungkyu, ZHU, Moyu, DENG, Liguang, CHEN, Zhen, KIM, Hyungkyu, ZHU, Moyu, LIU, Yingming, DENG, Liguang, CHEN, Zhen, KIM, Hyungkyu, ZHU, Moyu, LIU, Yingming, CHENG, Jun, DENG, Liguang, CHEN, Zhen, KIM, Hyungkyu, ZHU, Moyu, LIU, Yingming, CHENG, Jun, ZHAI, Ming] No.10 Jiuxianqiao Rd.Chaoyang DistrictBeijing 100015;No. 8 Xihuanzhonglu, BDABeijing 100176 Provided is a driving method to drive an LCD panel having rows of pixels includes obtaining source data signals of a plurality of frames for the LCD panel; inputting a source data signal of one frame of the plurality of frames; and inverting polarity of the source data signal of the one frame before scanning sequentially the rows of pixels. The driving method also includes configuring at least one of timing of the source data signal and timing of scanning a first row of the rows of pixels to cause a time overlap between an actual scanning time of the first row and a time period when the source data signal is at a threshold value to be no less than an original scanning time of the first row; scanning the first row of the rows of pixels; and scanning rest of the rows of pixels to complete displaying the one frame.
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MUTANT GLUTAMATE DEHYDROGENASE FOR THE CONVERSION OF HOMOSERINE INTO 4-HYDROXY-2-KETOBUTYRATE PCT/EP2015/072806
[CHEN, Zhen, CHEN, Zhen, GENG, Feng, CHEN, Zhen, GENG, Feng, ZENG, An-Ping, CHEN, Zhen, GENG, Feng, ZENG, An-Ping, DISCHERT, Wanda, CHEN, Zhen, GENG, Feng, ZENG, An-Ping, DISCHERT, Wanda, SOUCAILLE, Philippe] Biopole Clermont-LimagneF-63360 Saint Beauzire The present invention concerns a method for the production of derivatives of 4-hydroxy-2-ketobutyrate chosen among 1,3-propanediol or 2,4-dihydroxybutyrate by culturing a genetically modified microorganism for the production of the desired derivative of 4-hydroxy-2-ketobutyrate, the microorganism further comprising a gene coding for a mutant glutamate dehydrogenase converting by deamination L-homoserine into 4-hydroxy-2-ketobutyrate. The invention also concerns said genetically modified microorganism.
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WIRELESS SENSOR NETWORK CHARGING METHOD FOR MULTI-CHARGE NODES PCT/CN2015/095390
[YUAN, Lifen 袁莉芬, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Zhijie 袁志杰, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Zhijie 袁志杰, CHENG, Zhen 程珍, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Zhijie 袁志杰, CHENG, Zhen 程珍, ZHAO, Deqin 赵德勤, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Zhijie 袁志杰, CHENG, Zhen 程珍, ZHAO, Deqin 赵德勤, SUN, Yesheng 孙业胜, YUAN, Lifen 袁莉芬, CHEN, Peng 陈鹏, HE, Yigang 何怡刚, LUO, Shuai 罗帅, YUAN, Zhijie 袁志杰, CHENG, Zhen 程珍, ZHAO, Deqin 赵德勤, SUN, Yesheng 孙业胜, WU, Lei 吴磊] 193 Tunxi Road, Baohe District 中国安徽省合肥市包河区屯溪路193号, Anhui 230009Hefei, Anhui 230009 A wireless sensor network charging method for multi-charge nodes, comprising the following steps: (1) establishing a WSNs model; (2) dividing a field range of charging trolleys; and (3)charging all the charging trolleys: (a) initializing: l=0, and j=0, wherein l is the total number of received alarm nodes, and j is the number of an alarmed node; (b) receiving an alarm signal, updating values about l and j, generating a shortest charging path sl, and computing an energy discriminant vector; (c) if a vector element meets Qlj≤%5B and j=1,2,…,l, executing, according to the corresponding shortest charging path sl, a charging task on l alarm nodes, otherwise, returning to continuously update the values about l and j; (d) executing the charging task; and (e) judging whether the charging trolleys are required to go back to a parking lot to supplement energy or not, enabling the charging trolleys to go back to the parking lot to supplement the energy if yes, and otherwise, returning to continuously update the values about l and j and the vector element Qlj. The present invention can adaptively change a charging strategy according to energy change of a sensor; and all charging trolleys are independent from each other, and the present invention is simple and reliable. A wireless sensor network charging method for multi-charge nodes, comprising the following steps: (1) establishing a WSNs model; (2) dividing a field range of charging tro
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EXPRESSION ELEMENT, EXPRESSION CASSETTE, AND VECTOR CONTAINING SAME PCT/CN2014/095340
[LIN, Jiunn-Horng 林俊宏, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, FANG, Chien-Yu 方健宇, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, FANG, Chien-Yu 方健宇, ZENG, Hao-Zhen 曾晧真, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, FANG, Chien-Yu 方健宇, ZENG, Hao-Zhen 曾晧真, LAI, Jian-Fong 赖建逢, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, FANG, Chien-Yu 方健宇, ZENG, Hao-Zhen 曾晧真, LAI, Jian-Fong 赖建逢, HUANG, Weng-Zeng 黄文正, LIN, Jiunn-Horng 林俊宏, WANG, Jyh-Perng 王志鹏, CHEN, Zeng-Weng 陈正文, FANG, Chien-Yu 方健宇, ZENG, Hao-Zhen 曾晧真, LAI, Jian-Fong 赖建逢, HUANG, Weng-Zeng 黄文正, HSUAN, Shih-Ling 宣诗玲] No.1, Ln. 51, Dahu Road, Xiangshan Dist. 中国台湾省新竹市香山区大湖路51巷1号, Taiwan 300Hsinchu City, Taiwan 300 Disclosed are an expression element, an expression cassette, and a vector constructed thereby. The expression element has a promoting effect on the expression quantity of genes to be expressed, and thus has a highly industrial utilization value.
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PNEUMATIC DISC BRAKE PRESSURE ARM HAVING BEARING LIMITING STRUCTURE PCT/CN2015/084784
[CHEN, Zhen 陈振, CHEN, Zhen 陈振, SU, Song 苏松, CHEN, Zhen 陈振, SU, Song 苏松, SHI, Chao 石潮, CHEN, Zhen 陈振, SU, Song 苏松, SHI, Chao 石潮, YANG, Xiong 杨熊] NO.198, Chuangye Road, Economic Technological Development Zone 中国湖北省武汉市经济技术开发区创业路198号, Hubei 430058Wuhan, Hubei 430058 Disclosed is a pneumatic disc brake pressure arm having a bearing limiting structure. One end of a pressure arm (1) is a force-bearing part (1a) and the other end is a force-exerting part (1b). An inner surface of the force-exerting part (1b) is a rotation arc face (1d) and an outer surface is a propulsion arc face. A fulcrum cylindrical post (2) is arranged in a recess formed by the rotation arc face (1d) and is arranged concentrically with the rotation arc face (1d), multiple needle bearings (3) are provided around the fulcrum cylindrical post (2), a positioning block (6) is arranged on one side of the fulcrum cylindrical post (2) away from the rotation arc face (1d). A force-exerting part (1b) is provided with a limiting block (1c) at an upper end of the rotation arc face (1d) and is provided with a limiting plate (4) at a lower end of the rotation arc face (1d), and a lower end face of the limiting block (1c) is higher than the inner surface of the positioning block (6) and lower than a top part of the needle bearings (3) near the limiting block (1c). The pneumatic disc brake pressure arm having a bearing limiting structure ensures that, by means of the limiting block (1c) functioning together with the limiting plate (4), the needle bearings (3) are located within the range of the rotation arc face (1d) of the pressure arm (1) throughout.
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CONFERENCE MANAGEMENT METHOD AND TERMINAL UTILIZING IBEACONS TECHNOLOGY PCT/CN2015/072091
[SHI, Zhen 石贞, SHI, Zhen 石贞, CHEN, Xiling 陈喜玲, SHI, Zhen 石贞, CHEN, Xiling 陈喜玲, YANG, Yan 杨燕, SHI, Zhen 石贞, CHEN, Xiling 陈喜玲, YANG, Yan 杨燕, GAO, Ke 高科] No.86, Hechang 7th West Road, ZhongKai Hi-tech Development District 中国广东省惠州市仲恺高新区和畅七路西86号, Guangdong 516006Huizhou, Guangdong 516006 Disclosed is a conference management method for reservation and registration. The method comprises: a Bluetooth terminal receives broadcast information of an ibeacons device arranged in a conference room, starts a conference management application after parsing the broadcast information, sends a reservation request for at least one conference room to a server, and receives a reservation result sent by the server after the server performs analysis processing on the reservation request, so that the reservation step is completed; and after enabling the conference management application, at least one Bluetooth terminal measures the distance between the terminal and the ibeacons device in the conference room according to the information obtained by parsing, sends the distance to the server, receives from the server the position relationships between the terminal and other mobile terminals and the ibeacons device in the current conference room and the registration states of the terminal and the other mobile terminals, and displays the position relationships and the registration states, so that the automatic registration step is completed. Also disclosed is a Bluetooth terminal for reservation or registration. By means of the present invention, a Bluetooth terminal is utilized for reserving a conference room and carrying out registration automatically, so that the automation of a conference management system is achieved, and the conference management efficiency is improved.
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