[SOMMERGRUBER, Wolfgang, KRAUT, Norbert, SCHWEIFER, Norbert, RETTIG, Wolfgang, HILBERG, Frank, SOLCA, Flavio, STEEGMAIER, Martin] {Binger Strasse 173 55216 Ingelheim am Rhein;DE(DE)(DE)}{Binger Strasse 173 55216 Ingelheim am Rhein;DE(DE)(DE)}{Linzerstrasse 19, Haus 4 A-3002 Purkersdorf;AT(AT)(AT)}{Melkergasse 23-25 A-2500 Baden;AT(DE)(AT)}{Spitzweg 95 A-1210 Wien;AT(AT)(AT)}{Rysergasse 60 A-1230 Vienna;AT(DE)(AT)}{Pilgramgasse 18/22 A-1050 Vienna;AT(DE)(AT)}{Gesslgasse 10/6 A-1230 Wien;AT(CH)(AT)}{Leni-Matthaei-Weg 29 72762 Reutlingen;DE(DE)(DE)} The invention is based on the finding that indolinones are useful for the therapy of diseases which result from aberrant activity of certain tyrosine kinases selected from the group comprising ABL, FGFR3, FLT3, and RET.

[SOMMERGRUBER, Wolfgang, KRAUT, Norbert, SCHWEIFER, Norbert, RETTIG, Wolfgang, HILBERG, Frank, SOLCA, Flavio, STEEGMAIER, Martin] {Binger Strasse 173 55216 Ingelheim Am Rhein;DE(DE)(DE)}{Binger Strasse 173 55216 Ingelheim Am Rhein;DE(DE)(DE)}{Linzerstrasse 19, Haus 4 A-3002 Purkersdorf;AT(AT)(AT)}{Melkergasse 23-25 A-2500 Baden;AT(DE)(AT)}{Spitzweg 95 A-1210 Wien;AT(AT)(AT)}{Rysergasse 60 A-1230 Vienna;AT(DE)(AT)}{Pilgramgasse 18/22 A-1050 Vienna;AT(DE)(AT)}{Gesslgasse 10/6 A-1230 Wien;AT(CH)(AT)}{Leni-Matthaei-Weg 29 72762 Reutlingen;DE(DE)(DE)} The invention is based on the finding that indolinones are useful for the therapy of diseases which result from aberrant activity of a kinase selected from the group comprising AXL, FLT3, MEK1, and RET.

[Bodo Betzemeier, Trixi Brandl, Steffen Breitfelder, Ralph Brueckner, Thomas Gerstberger, Michael Gmachl, Matthias Grauert, Frank Hilberg, Christoph Hoenke, Matthias Hoffmann, Maria Impagnatiello, Dirk Kessler, Christian Klein, Bernd Krist, Udo Maier, Darryl McConnell, Charlotte Reither, Stefan Scheuerer, Andreas Schoop, Norbert Schweifer, Oliver Simon, Martin Steegmaier, Steffen Steurer, Irene Waizenegger, Ulrike Weyer-Czernilofsky, Andreas Zoephel] AT,,Vienna;DE,,Warthausen;DE,,Assmannshardt;AT,,Vienna;AT,,Vienna;AT,,Vienna;DE,,Biberach;AT,,Vienna;DE,,Ingelheim;DE,,Mittelbiberach;AT,,Vienna;AT,,Vienna;AT,,Vienna;AT,,Vienna;DE,,Senden;AT,,Vienna;AT,,Vienna;DE,,Warthausen;AT,,Vienna;AT,,Vienna;AT,,Vienna;AT,,Vienna;AT,,Vienna;AT,,Vienna;AT,,Baden;AT,,Vienna; The present invention encompasses compounds of the general formula (1) in which R1 to R3 are defined as in claim 1, which are suitable for treating diseases which are characterized by excessive or anomalous cell proliferation, and their use for producing a pharmaceutical having the abovementioned properties.

[BETZEMEIER, Bodo, BRANDL, Trixi, BREITFELDER, Steffen, BRUECKNER, Ralph, GERSTBERGER, Thomas, GMACHL, Michael, GRAUERT, Matthias, HILBERG, Frank, HOENKE, Christoph, HOFFMANN, Matthias, IMPAGNATIELLO, Maria, KESSLER, Dirk, KLEIN, Christian, KRIST, Bernd, MAIER, Udo, MCCONNELL, Darryl, REITHER, Charlotte, SCHEUERER, Stefan, SCHOOP, Andreas, SCHWEIFER, Norbert, SIMON, Oliver, STEEGMAIER, Martin, STEURER, Steffen, WAIZENEGGER, Irene, WEYER-CZERNILOFSKY, Ulrike, ZOEPHEL, Andreas] {CD-Patents Binger Strasse 173 55216 INGELHEIM AM RHEIN;DE(DE)(DE)}{CD-Patents Binger Strasse 173 55216 INGELHEIM AM RHEIN;DE(DE)(DE)}{Rainergasse 34 A-2721 Bad Fischau;AT(DE)(AT)}{Murbacherstr.27 CH-4056 Basel;CH(DE)(CH)}{Weihergasse 21 88433 Assmannshardt;DE(DE)(DE)}{Gallgasse 68/2 A-1130 WIEN;AT(DE)(AT)}{Reibergasse 9-23/H11 A-1230 WIEN;AT(DE)(AT)}{Beckmanngasse 55/12 A-1140 WIEN;AT(AT)(AT)}{Osterbergstrasse 10 88400 Biberach;DE(DE)(DE)}{Pilgramgasse 18/22 A-1050 WIEN;AT(DE)(AT)}{Turnierstrasse 43 55218 Ingelheim;DE(DE)(DE)}{Sonnenweg 17 88441 Mittelbiberach;DE(DE)(DE)}{Untere Weissgerberstrasse 36/12 A-1030 WIEN;AT(IT)(AT)}{Schoenbrunner Strasse 170/1/9 A-1120 WIEN;AT(DE)(AT)}{Burggasse 112/41 A-1070 WIEN;AT(DE)(AT)}{Kreuzstrasse 3 86450 Altenmuenster;DE(DE)(DE)}{Bierweg 19 89250 Senden;DE(DE)(DE)}{Unterbergergasse 4/32 A-1200 WIEN;AT(AU)(AT)}{Ziedlergasse 9/13 A-1230 Wien;AT(AT)(AT)}{Hanns-Wanner Weg 21 88447 Warthausen;DE(DE)(DE)}{Beckmanngasse 38/14 A-1150 WIEN;AT(DE)(AT)}{Spitzweg 95 A-1210 Wien;AT(AT)(AT)}{Schloeglgasse 12/Top A4 A-1120 WIEN;AT(DE)(AT)}{Leni-Matthaei-Weg 29 72762 Reutlingen;DE(DE)(DE)}{Weimarer Strasse 103/7 A-1190 WIEN;AT(DE)(AT)}{Lechnerstrasse 13/18 A-1030 WIEN;AT(DE)(AT)}{Klesheimstrasse 28 A-2500 Baden;AT(DE)(AT)}{Trauttmansdorffgasse 17/1 A-1130 WIEN;AT(DE)(AT)} The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.

[BETZEMEIER BODO, BRANDL TRIXI, BREITFELDER STEFFEN, BRUECKNER RALPH, GERSTBERGER THOMAS, GMACHL MICHAEL, GRAUERT MATTHIAS, HILBERG FRANK, HOENKE CHRISTOPH, HOFFMANN MATTHIAS, IMPAGNATIELLO MARIA, KESSLER DIRK, KLEIN CHRISTIAN, KRIST BERND, MAIER UDO, MCCONNELL DARRYL, REITHER CHARLOTTE, SCHEUERER STEFAN, SCHOOP ANDREAS, SCHWEIFER NORBERT, SIMON OLIVER, STEEGMAIER MARTIN, STEURER STEFFEN, WAIZENEGGER IRENE, WEYER-CZERNILOFSKY ULRIKE, ZOEPHEL ANDREAS] DE

[SCHWEIFER, Norbert, SCHERL-MOSTAGEER, Marwa, SOMMERGRUBER, Wolfgang, ABSEHER, Roger] {Postfach 200 55216 Ingelheim am Rhein;DE(DE)(DE)}{Herzmanskystrasse 20/2/5 A-1140 Wien;AT(AT)(AT)}{Glockengasse 21/1/4 A-1020 Wien;AT(AT)(AT)}{Linzerstrasse 19 Haus 4 A-3002 Purkersdorf;AT(AT)(AT)}{Schlossgasse 15/16 A-1050 Wien;AT(AT)(AT)} The invention relates to the tumour-associated antigen B345 and to DNA molecules which code for the same.

[BETZEMEIER, Bodo, BRANDL, Trixi, BREITFELDER, Steffen, BRUECKNER, Ralph, GERSTBERGER, Thomas, GMACHL, Michael, GRAUERT, Matthias, HILBERG, Frank, HOENKE, Christoph, HOFFMANN, Matthias, IMPAGNATIELLO, Maria, KESSLER, Dirk, KLEIN, Christian, KRIST, Bernd, MAIER, Udo, MCCONNELL, Darryl, REITHER, Charlotte, SCHEUERER,Stefan, SCHOOP, Andreas, SCHWEIFER, Norbert, SIMON, Oliver, STEEGMAIER, Martin, STEURER, Steffen, WAIZENEGGER, Irene, WEYER-CZERNILOFSKY, Ulrike, ZOEPHEL, Andreas] DE,55216 Ingelheim am Rhein,CD Patents, Binger Strasse 173;DE,55216 Ingelheim am Rhein,CD-Patents Binger Strasse 173;

[BETZEMEIER BODO, BRANDL TRIXI, BREITFELDER STEFFEN, BRUECKNER RALPH, GERSTBERGER THOMAS, GMACHI MICHAEL, GRAUERT MATTHIAS, HILBERG FRANK, HOENKE CHRISTOPH, HOFFMANN MATTHIAS, IMPAGNATIELLO MARIA, KESSLER DIRK, KLEIN CHRISTIAN, KRIST BERND, MAIER UDO, MCCONNELL DARRYL, REITHER CHARLOTTE, SCHEUERER STEFAN, SCHOOP ANDREAS, SCHWEIFER NORBERT, SIMON OLIVER, STEEGMAIER MARTIN, STEURER STEFFEN, WAIZENEGGER IRENE, WEYER-CZERNILOFSKY ULRIKE, ZOEPHEL ANDREAS] DE

[HILBERG DR FRANK, GRAUERT DR MATTHIAS, HOENKE CHRISTOPH, WEYER-CZERNILOFSKY DR ULRIKE, HOFFMANN MATTHIAS, BREITFELDER STEFFEN, BRANDL TRIXI, BETZEMEIER BODO, BRUECKNER RALPH, GERSTBERGER THOMAS, GMACHL MICHAEL, IMPAGNATIELLO MARIA, KESSLER DIRK, KLEIN CHRISTIAN, KRIST BERND, MAIER UDO, MCCONNELL DARRYL, REITHER CHARLOTTE, SCHEUERER DR STEFAN, SCHOOP ANDREAS, SCHWEIFER NORBERT, SIMON OLIVER, STEEGMAIER MARTIN, STEURER STEFFEN, WAIZENEGGER IRENE, ZOEPHEL ANDREAS] DE

[SIMON OLIVER, KRIST BERND, HOFFMANN MATTHIAS, GRAUERT MATTHIAS, STEEGMAIER MARTIN, BRANDL TRIXI, KLEIN CHRISTIAN, STEURER STEFFEN, BRUECKNER RALPH, KESSLER DIRK, SCHWEIFER NORBERT, GERSTBERGER THOMAS, MAIER UDO, GMACHL MICHAEL, BREITFELDER STEFFEN, SCHEUERER STEFAN, WEYER-CZERNILOFSKY ULRIKE, WAIZENEGGER IRENE, REITHER CHARLOTTE, IMPAGNATIELLO MARIA, MCCONNELL DARRYL, HILBERG FRANK, BETZEMEIER BODO, SCHOOP ANDREAS, HOENKE CHRISTOPH, ZOEPHEL ANDREAS]