[WOLFGANG MUETZEL, MUETZEL WOLFGANG, HEINZ GRIES, GRIES HEINZ, HEINRICH PFEIFFER, PFEIFFER HEINRICH, ULRICH SPECK, SPECK ULRICH]

[WOLFGANG MUETZEL, MUETZEL WOLFGANG, HEINZ GRIES, GRIES HEINZ, HEINRICH PFEIFFER, PFEIFFER HEINRICH, ULRICH SPECK, SPECK ULRICH] Ionic compounds of the formula ＜IMAGE＞ wherein X is -CONR1R2, -CH2NHxAcyl or -CH2OH; Y is -NR3R4, -NHxAcyl or OR5; R1, R2, R3 and R4 can be identical or different, and each is hydrogen, C1-6- alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3-alkoxy group, R5 is C1-6 alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3-alkoxy group, and Acyl, which can be the same or different in X and Y, is C2-6-alkanoyl or C2-6-alkanoyl substituted by 1-4 OH groups and/or by one C1-3-alkoxy group, or a physiologically compatible salt thereof with an inorganic or organic base, have valuable properties as X-ray contrast agents.

[WOLFGANG MUETZEL, MUETZEL WOLFGANG, HEINZ GRIES, GRIES HEINZ, HEINRICH PFEIFFER, PFEIFFER HEINRICH, ULRICH SPECK, SPECK ULRICH] Ionic compounds of the formula ＜IMAGE＞ wherein X is -CONR1R2, -CH2NHxAcyl or -CH2OH; Y is -NR3R4, -NHxAcyl or OR5; R1, R2, R3 and R4 can be identical or different, and each is hydrogen, C1-6- alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3-alkoxy group, R5 is C1-6 alkyl or C2-8-alkyl substituted by 1-5 OH groups and/or by one C1-3-alkoxy group, and Acyl, which can be the same or different in X and Y, is C2-6-alkanoyl or C2-6-alkanoyl substituted by 1-4 OH groups and/or by one C1-3-alkoxy group, or a physiologically compatible salt thereof with an inorganic or organic base, have valuable properties as X-ray contrast agents.

[GRIES HEINZ DR, MUETZEL WOLFGANG DR, ZURTH CHRISTIAN DR, WEINMANN HANNS-JOACHIM DR] DE

[GRIES HEINZ DR, MUETZEL WOLFGANG DR, ZURTH CHRISTIAN DR, WEINMANN HANNS-JOACHIM DR] DE

[GRIES HEINZ, PFEIFFER HEINRICH, SPECK ULRICH, MUETZEL WOLFGANG] DE 1. Compounds of the general formula I see diagramm : EP0032387,P17,F5 in which X represents the radical -CO.N.R1 R2 , -CCOR3 , -CH2 .NH.R7 or -CH2 OH, Y represents the radical -N.R1 R2 or -OR3 , Z represents the radical -N.R1 R2 , -NH.R7 , -NH.(sugar radical) or -OR3 , -N.R1 R2 in X, Y and Z being the same or different, R1 and R2 are the same or different and represent a hydrogen atom or a straight-chain or branched-chain alkyl radical having from 1 to 6 carbon atoms or a mono- or polyhydroxylated straight-chain or branched-chain alkyl radical having from 2 to 8 carbon atoms and from 1 to 5 hydroxy groups, R3 represents an alkyl radical having from 1 to 4 carbon atoms or a hydroxylated alkyl radical having from 2 to 4 carbon atoms and from 1 to 3 hydroxy groups, and R7 represents the acyl radical of an aliphatic carboxylic acid having from 2 to 5 carbon atoms which may optionally be substituted by from 1 to 5 hydroxy groups, it being possible for the hydroxy groups also to be functionally modified.

[SPECK ULRICH, KLIEGER ERICH, MUETZEL WOLFGANG] Compounds of the formula ＜IMAGE＞ (I) wherein X is alkylene, optionally substituted by hydroxy, methoxy or amino; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-4 alkyl, or C2-4-alkyl substituted by 1-3 OH groups; R3 is hydrogen, C1-4 alkyl, or C2-4-alkyl substituted by 1-3 OH groups; R4 is hydrogen, C1-4-alkyl, or C2-4-alkyl substituted by 1-3 OH groups; R5 is C2-4-alkyl substituted by 1-3 OH groups; R6 is hydrogen, C1-4-alkyl or C2-4-alkyl substituted by 1-3 OH groups; and R7 is C2-4-alkyl substituted by 1-3 OH groups, or a salt thereof with an acid are useful as opaquing agents in x-ray contrast media.

[GRIES HEINZ DR, MUETZEL WOLFGANG DR] DE The invention relates to 2,4,6-trihalogenated 3-carbamoylphenoxycarboxylic acids of the general formula I ＜IMAGE＞ in which Hal is a chlorine, bromine or iodine atom, R＜1＞ is a hydrogen atom or a lower alkyl radical having 1 to 4 carbon atoms, and k = 0; 2 to 4, l = 0 or 1 and m = 0; 1 to 4, with the proviso that l = 0 when k = 0, and their salts with inorganic bases. The compounds of the formula I and their salts with inorganic bases have an extraordinarily high sweetening power and are outstandingly suitable as sweeteners (sweetening agents).

[GRIES HEINZ, DEUTSCH JULIUS, KLIEGER ERICH, NIEDBALLA ULRICH, RENNEKE FRANZ-JOSEF, CONRAD JUERGEN, MUETZEL WOLFGANG] DE

[HILMANN JUERGEN, HOFFMANN ROLF-RUEDIGER, MUETZEL WOLFGANG, ZIMMERMANN INGFRIED] DE The useful lifetime and the amount of microbubbles of a size less than 50 mu m produced by mechanical agitation of an aqueous liquid employed as an ultrasonic contrast medium are increased by employing a liquid containing dissolved therein a tenside which reduces the surface tension of the liquid and a compound which raises the viscosity of the liquid.