[Erwin Marti, Hans Rudolf Oswald, Peter Bülmayer, Wolfgang Marterer] CH,,Basel;CH,,Starrkirch-Wil;CH,,Arlesheim;DE,,Freiburg i. B.; The invention relates to new salts of valsartan or crystalline, also partly crystalline and amorphous salts of valsartan, the respective production and usage, and pharmaceutical preparations containing such a salt.

[Wolfgang Marterer, Mahavir Prashad, Edwin Bernard Villhauer, Liladhar Murlidhar Waykole, James Anthony Vivelo, Bertrand Sutter, Jean-Claude Bianchi, Raeann Wu, Denis Har, Piotr H. Karpinski, Massimo Pignone, Doris Stingelin, Eckart Buerger] CH CH,Basel The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

[MARTERER, Wolfgang, PRASHAD, Mahavir, VILLHAUER, Edwin Bernard, WAYKOLE, Liladhar Murlidhar, VIVELO, James Anthony, SUTTER, Bertrand, BIANCHI, Jean-Claude, WU, Raeann, HAR, Denis, KARPINSKI, Piotr H., PIGNONE, Massimo, STINGELIN, Doris, BUERGER, Eckart] CH,4056 Basel,Lichtstrasse 35; The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.

[WOLFGANG MARTERER] CH

[MARTERER WOLFGANG, MICKEL STUART JOHN] CH The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula (III), wherein R, R1, and R\' are as defined in the specification, or a salt thereof, and a compound of formula (IV) wherein R, R1, R2 and R\' are as defined in the specification, and processes of manufacturing these.

[MARTERER, Wolfgang, PRASHAD, Mahavir, VILLHAUER, Edwin Bernard, WAYKOLE, Liladhar Murlidhar, VIVELO, James Anthony, SUTTER, Bertrand, BIANCHI, Jean-Claude, WU, Raeann, HAR, Denis, KARPINSKI, Piotr H., PIGNONE, Massimo, STINGELIN, Doris, BUERGER, Eckart] CH,4056 Basel,Lichtstrasse 35; The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.

[MARTERER WOLFGANG, PRASHAD MAHAVIR, VILLHAUER EDWIN BERNARD, WAYKOLE LILADHAR MURLIDHAR, VIVELO JAMES ANTHONY, SUTTER BERTRAND, BIANCHI JEAN-CLAUDE, WU RAEANN, HAR DENIS, KARPINSKI PIOTR H, PIGNONE MASSIMO, STINGELIN DORIS, BUERGER ECKART] CH

[MARTERER WOLFGANG, PRASHAD MAHAVIR, VILLHAUER EDWIN BERNARD, WAYKOLE LILADHAR MURLIDHAR, VIVELO JAMES ANTHONY, SUTTER BERTRAND, HAR DENIS, KARPINSKI PIOTR H, PIGNONE MASSIMO, STINGELIN DORIS, BUERGER ECKART] CH The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza- bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

[MARTERER WOLFGANG, PRASHAD MAHAVIR, VILLHAUER EDWIN BERNARD, WAYKOLE LILADHAR MURLIDHAR, VIVELO JAMES ANTHONY, SUTTER BERTRAND, BIANCHI JEAN-CLAUDE, WU RAEANN, HAR DENIS, KARPINSKI PIOTR H, PIGNONE MASSIMO, STINGELIN DORIS, BUERGER ECKART] CH The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza- bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.

[MARTERER WOLFGANG] CH An alternative synthesis of 2(S), 4(S), 5(S), 7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amide compounds or pharmaceutically acceptable salts thereof which uses the synthetic pathway defined in Schemes 1-3. Novel intermediates are used in the preparation of the above target compound.