[Peter D. Mezes, Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong, Stacie J. Casman, Ferenc L. Boldog, Richard A. Shimkets, Linda Gorman, Andrew J. Eisen, Steven K. Spaderna, Corine A.M. Vernet, Constance Berghs, Kimberly A. Spytek, Vincent A. DiPippo, Bryan D. Zerhusen, John A. Peyman, Karen Ellerman, David J. Stone, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Shlomit R. Edinger] US CT Old Lyme Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[GUO, Xiaojia, LI, Li, PATTURAJAN, Meera, SHIMKETS, Richard, A., CASMAN, Stacie, J., MALYANKAR, Uriel, M., TCHERNEV, Velizar, T., VERNET, Corinne, A.M., SPYTEK, Kimberly A., SHENOY, Suresh, G., ALSOBROOK, John, P., II, EDINGER, Schlomit, PEYMAN, John, A., STONE, David, J., ELLERMAN, Karen, GANGOLLI, Esha, A., BOLDOG, Ferenc, L., COLMAN, Steven, D., EISEN, Andrew, J., LIU, Xiaohong, PADIGARU, Muralidhara, SPADERNA, Steven, K., ZERHUSEN, Bryan, D.] 555 Long Wharf Drive 11th floor New Haven, CT 06511;713 Robert Frost Drive Branford, CT 06405;56 Jerimoth Drive Branford, CT 06405;45 Harrison Avenue Apartment 1C Branford, CT 06405;191 Leete Street New Haven, CT 06516;17 Peck Street North Haven, CT 06473;35 Averill Place Branford, CT 06405;45 Jefferson Road #3-12 Branford, CT 06405;1739 Foron Road, Box L6 North Branford, CT 06405;28 Court Street, #1 New Haven, CT 06511;15 Millwood Drive Branford, CT 06405;60 Lake Drive Madison, CT 06443;322 East Main Street Branford, CT 06405;336 West Rock Avenue New Haven, CT 06515;223 Whitehorn Drive Guilford, CT 06437;87 Montoya Drive Branford, CT 06405;383 Walden Green Branford, CT 06405;1687 Hartford Turnpike North Haven, CT 06473;24 Andy Lane Guilford, CT 06437;12412 St. James Road Rockville, MD 20850;96 Montoya Circle Branford, CT 06405;71 Hampton Park Branford, CT 06405;261 Deerfield Drive Berlin, CT 06037;337 Monticello Drive Branford, CT 06405 Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

[Bryan D. Zerhusen, Meera Patturajan, Ramesh Kekuda, Charles E. Miller, Daniel K. Rieger, Carol E.A. Pena, Richard A. Shimkets, Li Li, Constance Berghs, Mei Zhong, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Muralidhara Padigaru, Glennda Smithson, Weizhen Ji, Linda Gorman, Corine A.M. Vernet, Mario W. Leite, Xiaojia Sasha Guo, David W. Anderson, Kimberly A. Spytek, Valerie Gerlach, Catherine E. Burgess, Nikolai V. Khramtsov, Tatiana Ort, Karen Ellerman, Luca Rastelli, Michele L. Agee, Amitabha Chaudhuri, John S. Chant, Vincent A. DiPippo, Shlomit R. Edinger, Andrew J. Eisen, Esha A. Gangolli, Loic Giot, Chean Eng Ooi, Mark E. Rothenberg, Steven K. Spaderna, Tord Hjalt, Xiaohong Liu, Raymond J. Taupier, Elina Catterton, Suresh G. Shenoy] US CT Branford The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[Peter D. Mezes, Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong, Stacie J. Casman, Ferenc L. Boldog, Richard A. Shimkets, Linda Gorman, Andrew J. Eisen, Steven K. Spaderna, Corine A.M. Vernet, Constance Berghs, Kimberly A. Spytek, Vincent A. DiPippo, Bryan D. Zerhusen, John A. Peyman, Karen Ellerman, David J. Stone, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Shlomit R. Edinger, Edward Z. Voss, Charles E. Miller] US CT Old Lyme Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Elina Catterton, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Valerie Gerlach, Linda Gorman, Xiaojia Sasha Guo, Michael E. Jeffers, Ramesh Kekuda, Li Li, Uriel M. Malyankar, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Suresh G. Shenoy, Richard A. Shimkets, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong] US CT Branford The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[Michele L. Agee, John P. Alsobrook, David W. Anderson, Constance Berghs, Ferenc L. Boldog, Catherine E. Burgess, Elina Catterton, Vincent A. DiPippo, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, Bonnie Gould Rothberg, Xiaojia Sasha Guo, John L. Herrmann, Yuan-Di Halvorsen, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, William J. LaRochelle, Denise M. Lepley, Li Li, John R. MacDougall, Charles E. Miller, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Mei Zhong] US CT Wallingford The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[AGEE, Michele, L., ALSOBROOK, John, P., II, ANDERSON, David, W., BERGHS, Constance, BOLDOG, Ferenc, L., BURGESS, Catherine, E., CATTERTON, Elina, DIPIPPO, Vincent, A., EDINGER, Shlomit, R., EISEN, Andrew, ELLERMAN, Karen, GANGOLLI, Esha, A., GERLACH, Valerie, L., GORMAN, Linda, GOULD-ROTHBERG, Bonnie, E., GUO, Xiaojia, HERRMANN, John, L., HALVORSEN, Yuan-Di, JI, Weizhen, KEKUDA, Ramesh, KHRAMTSOV, Nikolai, V., LAROCHELLE, William, J., LEPLEY, Denise, M., LI, Li, MACDOUGALL, John, R., MILLER, Charles, E., ORT, Tatiana, PADIGARU, Muralidhara, PATTURAJAN, Meera, PENA, Carol, E., A., PEYMAN, John, A., RIEGER, Daniel, K., ROTHENBERG, Mark, E., SHENOY, Suresh, G., SMITHSON, Glennda, SPADERNA, Steven, K., SPYTEK, Kimberly, A., STONE, David, J., TAUPIER, Raymond, J., Jr., VERNET, Corine, A., M., VOSS, Edward, Z., ZHONG, Mei] 555 Long Wharf Drive 11th Floor New Haven, CT 06511;107 Knollwood Road Wallingford, CT 06492;60 Lake Drive Madison, CT 06443;85 Montoya Drive Branford, CT 06405;459 Orange Street New Haven, CT 06511;1687 Hartford Turnpike North Haven, CT 06473;90 Carriage Hill Drive Wethersfield, CT 06109;584 Boston Post Road Madison, CT 06443;156 North Atwater Street East Haven, CT 06512;766 Edgewood Avenue New Haven, CT 06515;12412 St. James Road Rockville, MD 20850;87 Montoya Drive Branford, CT 06405;31 Strawberry Hill Road Madison, CT 06443;18 Rock Pasture Road Branford, CT 06405;329 Monticello Drive Branford, CT 06405;1701 Moose Hill Road Guilford, CT 06437;713 Robert Frost Drive Branford, CT 06405;78 Barnshed Lane Guilford, CT 06437;Curagen Corporation 555 Long Wharf Drive 11th Floor New Haven, CT 06511;375 Old Rock Road Brandford, CT 06405;71 Aiken Street Unit R3 Norwalk, CT 06851;38 Montoya Circle Branford, CT 06405;15 Devonshire Lane Madison, CT 06443;51 Church Street Branford, CT 06405;56 Jerimoth Drive Branford, CT 06405;117 Russel Street Hamden, CT 06517;98 Saddle Hill Drive Guilford, CT 06437;85 Viscount Drive Apartment 61A Milford, CT 06460;71 Hampton Park Branford, CT 06405;45 Harrison Avenue Apartment 1C Branford, CT 06405;4766 Durham Road Guilford, CT 06437;336 West Rock Avenue New Haven, CT 06515;10A McKinnel Court Branford, CT 06405;2 Allen Road Clinton, CT 06413;15 Millwood Drive Branford, CT 06405;125 Michael Drive Guilford, CT 06435;261 Deerfield Drive Berlin, CT 06037;28 Court Street, Number 1 New Haven, CT 06511;223 Whitehorn Drive Guilford, CT 06437;34 Pardee Place Extension East Haven, CT 06512;1739 Foxon Road Apartment L6 Branford, CT 06471;123 Knollwood Drive Wallingford, CT 06492;152 Brushy Plain Road Branford, CT 06405 The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[ANDERSON, David, W., BERGHS, Constance, BOLDOG, Ferenc, L., BURGESS, Catherine, E., CASMAN, Stacie, J., CATTERTON, Elina, EDINGER, Shlomit, EISEN, Andrew, ELLERMAN, Karen, GERLACH, Valerie, GORMAN, Linda, GUO, Xiaojia, JEFFERS, Michael, KEKUDA, Ramesh, LI, Li, MALYANKAR, Uriel, M., MILLER, Charles, E., PADIGARU, Muralidhara, PATTURAJAN, Meera, PENA, Carol, E., A., RASTELLI, Luca, SHENOY, Suresh, SHIMKETS, Richard, A., SPADERNA, Steven, K., SPYTEK, Kimberly, A., STONE, David, J., TAUPIER, Raymond, J., Jr., VERNET, Corine, A., M., VOSS, Edward, Z., ZHONG, Mei] 555 Long Wharf Drive 11th floor New Haven, CT 06511;85 Montoya Drive Branford, CT 06405;459 Orange Street New Haven, CT 06511;1687 Hartford Turnpike North Haven, CT 06473;90 Carriage Hill Drive Wethersfield, CT 06109;17 Peck Street North Haven, CT 06473;584, Boston Post Road Madison, CT 06443;766 Edgewood Avenue New Haven, CT 06515;12412 St. James Road Rockville, MD 20850;87 Montoya Drive Branford, CT 06405;18 Rock Pasture Road Branford, CT 06405;329 Monticello Drive Branford, CT 06405;713 Robert Frost Drive Branford, CT 06405;14 Flax Mill Hollow Branford, CT 06405;71 Aiken Street Unit R3 Norwalk, CT 06851;56 Jerimoth Drive Branford, CT 06405;229 Brandford Road, #330 Branford, CT 06405;98 Saddle Hill Drive Guilford, CT 06437;71 Hampton Park Branford, CT 06405;45 Harrison Avenue Apartment 1C Branford, CT 06405;604 Orange Street, #2 New Haven, CT 06511;52 Pepperbush Lane Guilford, CT 06437;15 Millwood Drive Branford, CT 06405;5 Indian Meadows Drive Guilford, CT 06437;261 Deerfield Drive Berlin, CN 06037;28 Court Street, #1 New Haven, CT 06511;223 Whitethorn Drive Guilford, CT 06437;34 Pardee Place Extension East Haven, CT 06512;1739 Foxon Road Apartment L6 Branford, CT 06471;123 Knollwood Drive Wallingford, CT 06492;45 Harrison Avenue Apartment 1B Branford, CT 06405 The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

[DECRISTOFARO, Marc, F., PADIGARU, Muralidhara, MILLER, Charles, TCHERNEV, Velizar, ZHONG, Haihong, ZHONG, Mei, ANDERSON, David, BALLINGER, Robert, GERLACH, Valerie, SPYTEK, Kimberly, A., RASTELLI, Luca, KEKUDA, Ramesh, GUO, Xiaojia, ZERHUSEN, Bryan, ANDREW, David, MEZES, Peter, PATTURAJAN, Meera, BURGESS, Catherine, E., EISEN, Andrew, WOLENC, Adam, BAUMGARTNER, Jason, SHIMKETS, Richard, A., GUSEV, Vladimir, VERNET, Corine, A., M., TAUPIER, Raymond, J., PENA, Carol, SHENOY, Suresh, LI, Li, CASMAN, Stacie, BOLDOG, Ferenc, FERNANDES, Elma, SMITHSON, Glennda, MALYANKAR, Uriel, TAILLON, Bruce, LIU, Xiaohong] 11th Floor 555 Long Wharf Drive New Haven, CT 06511;140 Mill Street #16-114 East Havev, CT 06112;71 Hampton Park Branford, CT 06405;98 Saddle Hill Drive Guilford, CT 06437;45 Jefferson Road #3-12 Branford, CT 06405;2269 Long Hill Road Guilford, CT 06437;Apartment 1B 45 Harrison Avenue Branford, CT 06405;11th Floor 555 Long Wharf Drive New Haven, CT 06511;25 Star Avenue Newington, CT 06111;18 Rock Pasture Road Branford, CT 06405;28 Court Street #1 New Haven, CT 06511;52 Pepperbush Lane Guilford, CT 06437;168 Lockwood Avenue Stamford, CT 06902;713 Robert Frost Drive Branford, CT 06405;337 Monticello Drive Branford, CT 06405;43A Linden Avenue Branford, CT 06405;7 Clark's Lane Old Lyme, CT 06371;Apartment 1C 45 Harrison Avenue Branford, CT 06405;90 Carriage Hill Drive Wethersfield, CT 06109;12412 Saint James Road Rockville, MD 20850;Apartment 206 500 Main Street East Haven, CT 06512;1697 Quinnipiac Avenue New Haven, CT 06513;5 Ludian Meadows Drive Guilford, CT 06437;1209 Durham Road Madison, CT 06443;Apartment L6 1739 Foxon Road Branford, CT 06471;34 Pardee Place Extension East Haven, CT 06512;604 Orange Street #2 New Haven, CT 06511;15 Millwood Drive Branford, CT 06405;56 Jerimoth Drive Branford, CT 06405;17 Peck Street North Haven, CT 06473;1687 Hartford Turnpike North Haven, CT 06473;77 Florence Road #2B Branford, CT 06405;125 Michael Drive Guilford, CT 06405;229 Branford Road #330 Branford, CT 06405;181 Elizabeth Lane Middletown, CT 06457;96 Montoya Circle Branford, CT 06405 Disclosed are novel polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

[John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong] US CT Madison Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.