[Markus Grosse, Klaus Martin Weber, Marco Thyes, Peter Klein, Elmar Vilsmaier] DE Ludwigshr The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.

[VILSMAIER, Elmar, GOERZ, Torsten, MILCH, Gunther, PETERSEN, Uwe, DALHOFF, Axel, SCHMUCK, Gabriele] D-51368 Leverkusen;Am Kumb 23 D-67731 Otterbach;Tirolfstrasse 27 D-67657 Kaiserslautern;Wilhelm-Raabe-Strasse 26 D-67663 Kaiserslautern;Auf dem Forst 4 D-51375 Leverkusen;Obere Bergerheide 40 D-42113 Wuppertal;Am Ringofen 17 D-42327 Wuppertal The invention relates to novel 3-azabicyclo[3.1.0]hexanes with a doubly protected amino group in position 6, and to a method for producing the same from chloramines or bicyclic N,O acetals or bicyclic nitriles. The two protective groups on the amino group in 6 and the group on N(3) can be specifically removed. The novel 3-azabicyclo[3.1.0]hexanes with a doubly protected amino group in position 6 are suitable for manufacturing pharmaceutical products, e.g. gyrase inhibitors, which can be modified by subsequently splitting off the protective groups.

[Peter Klein, Marco Thyes, Markus Grosse, Klaus Martin Weber, Elmar Vilsmaier] DE Waldstrasse The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.

[KLEIN, Peter, THYES, Marco, GROSSE, Markus, WEBER, Klaus, Martin, VILSMAIER, Elmar] Max-Planck-Ring 2 65205 Wiesbaden;Waldstrasse 61 67134 Birkenheide;Mendelsohnstrasse 31 67061 Ludwigshafen;Lindenstraße 12A 68723 Schwetzingen;Rottstraße 83 67061 Ludwigshafen;Am Kumb 23 67731 Otterbach The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicyclo[2.2.1.]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5: 1.

[GROSSE, Markus, WEBER, Klaus, Martin, THYES, Marco, KLEIN, Peter, VILSMAIER, Elmar] Max-Planck-Ring 2 65205 Wiesbaden;Lindenstraße 12A 68723 Schwetzingen;Rottstraße 83 67061 Ludwigshafen;Mendelsohnstrasse 31 67061 Ludwigshafen;Waldstrasse 61 67134 Birkenheide;Am Kumb 23 67731 Otterbach The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.