[Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft, Michael H. Zeldin] US MA Newton Highlands The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

[Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Jr., Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft, Michael H. Zeldin] ,Newton Highlands,MA,;,Brookline,MA,;,Brookline,MA,;,Beverly,MA,;,Littleton,MA,;,Bedford,MA,;,Meshanie Station,NJ,;,Woburn,MA,;,Somerville,MA,;,Burlington,MA,;,Concord,MA,;,Cambridge,MA,;,Littleton,MA,;,Cambridge,MA, The present invention provides substituted 11-phenyl-dibenzazepine compounds that are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

[BRUGNARA, Carlo, HALPERIN, Jose, FLUCKIGER, Rudolf, BELLOTT, Emile, M., Jr., LOMBARDY, Richard, John, CLIFFORD, John, J., GAO, Ying-Duo, HAIDAR, Reem, M., KELLEHER, Eugene, W., MOUSSA, Adel, M., SACHDEVA, Yesh, P., SUN, Minghua, TAFT, Heather, N.] 124 Mount Auburn Street Cambridge, MA 02138;55 Shattuck Street Cambridge, MA 02115;7100 Woodbine Avenue Suite 215 Markham Ontario L3R 5J2;33 Aberdeen Street Newton Highlands, MA 02161;1433 Beacon Street Brookline, MA 02146;24 Beaconsfield Road Brookline, MA 02146;4 York Terrace Beverly, MA 01915;21 Moore Lane Littleton, MA 02146;38 Roberts Drive Bedford, MA 01730;504 Justin Way Meshanie Station, NJ 08853;6 Westgate Drive Woburn, MA 01801;22 MacArthur Street #4 Somerville, MA 02114;34 Newbridge Avenue Burlington, MA 01803;324 Hayward Mill Road Concord, MA 01742;Westgate Apartments #E-6 290 Vassar Street Cambridge, MA 02139;171 Whitcomb Avenue Littleton, MA 01460 The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.

[GEBHARDT, Manette, M., SACHDEVA, Yesh, P.] 2850 Willow Pass Road Pittsburg, CA 94565-0031;639 Odin Drive Pleasant Hill, CA 94523;4421 Pembroke Drive Concord, CA 94518 A composition that includes a finely divided, fully imidized, polyimide dispersed in a non-volatile, fluidizing resin that is a liquid or low viscosity semi-solid at room temperature. The fluidizing resin is substantially insoluble in the polyimide at room temperature, but soluble in the polyimide at the elevated temperaturs during thermal processing. The composition has the flow characteristics of a highly filled liquid.

[SUN, Xiaoyong, SACHDEVA, Yesh, P., WILSON, Donna, Kaye, GABRIEL, Richard, L., RAM, Siya] 128 Spring Street Lexington, MA 02173;33 Harris Street, No. 11 Acton, MA 01720;324 Hayward Mill Road Concord, MA 01742;17 Jennifer Circle Billerica, MA 01821;60 Andrew Road Swampscott, MA 01907;9 Grant Road Winchester, MA 01890 The present invention relates to a method for the stereospecific synthesis of an enantiomer of a chiral amine, wherein the chiral amine has the formula: R1CH(NH2)R?2. R1 and R2¿ are each independently selected from the group consisting of alkyl, aryl and heterocyclic and radicals. This method is particularly useful for stereospecifically synthesizing S-dolaphenine. The method involves contacting a chiral enantioner of norephedrine with borane, within an aprotic solvent to form a complex for stereospecifically reducing oximies. The complex is then contacted with an oxime, thereby stereospecifically reducing said oxime to form an enantiomer of a chiral amine.

[Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft] US MA Newton Highlands The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof which are specific, potent and safe inhibitors of the Ca2+-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.

[Carlo Brugnara, Jose Halperin, Emile M. Bellot, Mark Froimowitz, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Falguni M. Kher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft] US MA Newton Highlands The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.

[Richard L. Gabriel, Adel M. Moussa, Sharon Fitzhenry, Changhua Liu, David A. Swanson, Brittany La, Salah Zahr, Yesh P. Sachdeva, Jurjus Jurayj] ,Swampscott,MA,;,Burlington,MA,;,Marblehead,MA,;,Carlisle,MA,;,Lexington,MA,;,Lawrence,MA,;,Acton,MA,;,Concord,MA,;,Acton,MA, The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: In Structural Formula I, R is an amine protecting group, and R 1 is an amino acid side-chain, a protected amino acid side-chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl group. The method involves contacting a 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. The 1-nitro-3-substituted-3-amino-2-propanol diastereomers are then separated by simulated moving bed chromatography to obtain one or more 1-nitro-3-substituted-3-amino-2-propanol diastereomer.

[CARLO BRUGNARA, JOSE HALPERIN, EMILE M. BELLOT JR, MARK FROIMOWITZ, RICHARD JOHN LOMBARDY, JOHN J. CLIFFORD, YING-DUO GAO, REEM M. HAIDER, EUGENE W. KELLEHER, FALGUNI M. KHER, ADEL M. MOUSSA, YESH P. SACHDEVA, MINGHUA SUN, HEATHER N. TAFT] US MA NEWTON HIGHLANDS The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of the Ca2+-activated potassium channel (Gardos channel) of erythrocytes. The compounds can be used as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation.

[BRUGNARA, Carlo, HALPERIN, Jose, FLUCKIGER, Rudolf, BELLOTT, Emile, M., Jr., LOMBARDY, Richard, John, CLIFFORD, John, J., GAO, Ying-Duo, HAIDAR, Reem, M., KELLEHER, Eugene, W., MOUSSA, Adel, M., SACHDEVA, Yesh, P., SUN, Minghua, TAFT, Heather, N., ZELDIN, Michael, H.] 124 Mount Auburn Street Cambridge, MA 02138;55 Shattuck Street Cambridge, MA 02115;7100 Woodbine Avenue, Suite 215 Markham Ontario L3R 5J2;33 Aberdeen Street Newton Highlands, MA 02161;1433 Beacon Street Brookline, MA 02146;24 Beaconsfield Road Brookline, MA 02146;4 York Terrace Beverly, MA 01915;21 Moore Lane Littleton, MA 02146;38 Roberts Drive Bedford, MA 01730;504 Justin Way Meshanie Station, NJ 08853;6 Westgate Drive Woburn, MA 01801;22 MacArthur Street #4 Somerville, MA 02114;34 Newbridge Avenue Burlington, MA 01803;324 Hayward Mill Road Concord, MA 01742;Westgate Apartments #E-6 290 Vassar Street;171 Whitcomb Avenue Littleton, MA 01460;1 Waterhouse Street Cambridge, MA 02138 The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.