[SASISEKHARAN, Ram, VISWANATHAN, Karthik, SOUNDARARAJAN, Venkataramanan, RAGURAM, Sasi, SASISEKHARAN, Viswanathan, SUBRAMANIAN, Vidya] 77 Massachusetts Avenue Cambridge, MA 02139-4307;4 Duval Way Bedford, MA 01730;35 Fremont Street, Apt. 2-1 Arlington, MA 02474;60 Wadsworth Street, Apt. 18-H Cambridge, MA 02142;34 Vliet Drive Hillsborough, NJ 08844;2130 Massachusetts Avenue, Apt. 7B Cambridge, MA 02140;156 Summer Street, Apt. #414 Somerville, MA 02143 The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.

[SASISEKHARAN, Ram, VISWANATHAN, Karthik, CHANDRASEKARAN, Aarthi, RAMAN, Rahul, SRINIVASAN, Aravind, RAGURAM, S., SASISEKHARAN, Viswanathan] 77 Massachusetts Avenue Cambridge, MA 02139;4 Duval Way Bedford, MA 01730;35 Fremont St. Apt. 2-1 Arlington, MA 02474;143 Albany Street, Apt# 401b Cambridge, MA 02139;132 Clocktower Drive #311 Waltham, MA 02452;218 Thorndike Street, #105 Cambridge, MA 02141;34 Vilet Drive Hillsborough, NJ 08844;4 Duval Way Bedford, MA 01730 Umbrella-topology glycan decoys, and systems and methods treating influenza infection utilizing them are disclosed.

[Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan] US MA Bedford The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.

[SASISEKHARAN, Ram, VISWANATHAN, Karthik, CHANDRASEKARAN, Aarthi, RAMAN, Rahul, SRINIVASAN, Aravind, RAGURAM, S., SASISEKHARAN, Viswanathan] 77 Massachusetts Avenue Cambridge, MA 02139-4307;16-561;16-560;Ashdown House #007b 305 Memorial Drive Cambridge, MA 02139;540 Memorial Drive, Apt 1610 Cambridge, MA 02139;218 Thorndike Street #105 Cambridge, MA 02141;34 Vliet Drive Hillsborough, NJ 08844;2130 Massachusetts Avenue, 7b Cambridge, MA 02140 The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

[Ram Sasisekharan, Karthik Viswanathan, Venkataramanan Soundararajan, S. Raguram, Viswanathan Sasisekharan, Vidya Subramanian] US MA Cambridge The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (HA) polypeptides and/or HA receptors, and reagents and methods relating thereto. The present invention provides a system for analyzing interactions between infolds and the interaction partners that bind to them.

[SASISEKHARAN, Ram, VISWANATHAN, Karthik, CHANDRASEKARAN, Aarthi, RAMAN, Rahul, SRINIVASAN, Aravind, RAGURAM, S., SASISEKHARAN, Viswanathan] 77 Massachusetts Avenue Cambridge, MA 02139;4 Duval Way Bedford, MA 01730;35 Fremont St. Apt. 2-1 Arlington, MA 02474;143 Albany Street, Apt# 401B Cambridge, MA 02139;132 Clocktower Drive #311 Waltham, MA 02452;218 Thorndike Street, #105 Cambridge, MA 02141;34 Vilet Drive Hillsborough, NJ 08844;4 Duval Way Bedford, MA 01730 The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

[Ram Sasisekharan, Karthik Viswanathan, Aarthi Chandrasekaran, Rahul Raman, Aravind Srinivasan, S. Raguram, Viswanathan Sasisekharan] US MA Cambridge The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

[COMOLLI, James, FINBERG, Robert, FYGENSON, Deborah K., SHRIVER, Zachary, SASISEKHARAN, Ram, WANG, Jennifer, VISWANATHAN, Karthik] 555 Technology Square Cambridge, Massachusetts 02139;77 Massachusetts Avenue Cambridge, Massachusetts 02139;Office of Technology & Industry Alliances 342 Lagoon Road, Mail Code 2055 Santa Barbara, California 93106-2055;225 Franklin Street, 12th Floor Boston, Massachusetts 02100;;;;;;; This disclosure provides compositions, kits, and methods useful for treating or preventing viral infection. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide composition.

[Akila Jayaraman, Karthik Viswanathan, Rahul Raman, Zachary H. Shriver, Ram Sasisekharan] US MA Waltham The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., H1 HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., H1 HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.

[RAMAN, Rahul, KOH, Xiaoying, VISWANATHAN, Karthik, SASISEKHARAN, Ram, CHANDRASEKARAN, Aarthi] 77 Massachusetts Avenue Cambridge, MA 02142;132 Clocktower Drive, Unit 311 Waltham, MA 02452;56 Webster Avenue Cambridge, MA 02141;3114 Stearns Hill Road Waltham, MA 02451;4 Duval Way Bedford, MA 01730;243 Buena Vista Avenue, #902 Sunnyvale, CA 94086 The disclosure provides methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections. Specifically, the disclosure provides engineered hemagglutinin (HA) polypeptides that show a strong ability to discriminate between umbrella-topology and cone-topology glycans. More specifically, the engineered HA polypeptides have certain particular amino acids residues at positions corresponding to 137, 193, 226, and 228 of the HA polypeptide. The disclosure further provides methods of using the engineered HA polypeptides for treating influenza infections in human.