[Nigel Graham Cooke, Frédèric Zecri, Nicolas Soldermann, Romain Wolf, Christina Hebach, Klemens Hoegenauer, Gregory John Hollingworth, Anette Von Matt, Ross Sinclair Strang, Alexander Baxter Smith, Paulo Fernandes Gomes Dos Santos, Nadege Graveleau, Frank Stowasser, Nicola Tufilli] CH Basel The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I),wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

[Lyn Howard Jones, Dannielle Frances Roberts, Ross Sinclair Strang] GB Sandwich The invention relates to compounds of formula (1)and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

[BORDAS VINCENT, FUREGATI MARKUS, HAMON JACQUES, HINRICHS JUERGEN HANS-HERMANN, HONG ZIYUE, LIMA FABIO, LIMAM FATMA, MOEBITZ HENRIK, NOCITO SANDRO, SCHMIEDEBERG NIKO, SCHOEPFER JOSEPH, STRANG ROSS, ZECRI FREDERIC, YU HUANGCHAO, ZHANG YONG, YANG XINKAN, ZHANG SISI, LI WEI] CH;CH;CH;CH;CH;CN;CH;CH;CH;CH;CH;CH;CH;US;CN;CN;CN;CN;CN

[COOKE, Nigel Graham, FERNANDES GOMES DOS SANTOS, Paulo Antonio, FURET, Pascal, HEBACH, Christina, HÖGENAUER, Klemens, HOLLINGWORTH, Gregory, KALIS, Christoph, LEWIS, Ian, SMITH, Alexander Baxter, SOLDERMANN, Nicolas, STAUFFER, Frédéric, STRANG, Ross, STOWASSER, Frank, TUFILLI, Nicola, VON MATT, Anette, WOLF, Romain, ZECRI, Frédéric] Lichtstrasse 35 CH-4056 Basel;;;;;;;;;;;;;;;;; The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.

[GLOSSOP, Paul, Alan, STRANG, Ross, Sinclair, WATSON, Christine, Anne, Louise, WOOD, Anthony] Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Research and Development European Patent Departement Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Research and Development European Patent Departement Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Research and Development European Patent Departement Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Research and Development European Patent Departement Ramsgate Road Sandwich Kent CT13 9NJ The invention relates to compounds of formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.

[Graham Lunn, John Mathias, Ross Strang] GB Canterbury The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I): or of the general formula (I′) in which A and R1 are as defined within, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, including the treatment diseases mediated by H3 ligands, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

[COOKE, Nigel Graham, FERNANDES GOMES DOS SANTOS, Paulo, GRAVELEAU, Nadege, HEBACH, Christina, HÖGENAUER, Klemens, HOLLINGWORTH, Gregory, SMITH, Alexander Baxter, SOLDERMANN, Nicolas, STOWASSER, Frank, STRANG, Ross, TUFILLI, Nicola, VON MATT, Anette, WOLF, Romain, ZECRI, Frédéric] Lichtstrasse 35 CH-4056 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Werk Klybeck Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharmaceuticals UK Limited Horsham Research Centre Wimblehurst Road Horsham Sussex RH12 5AB;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Werk Klybeck Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Pharma AG Postfach CH-4002 Basel;Novartis Institutes for BioMedical Research, Inc. 100 Technology Square Cambridge, Massachusetts 02139 The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

[STRANG ROSS SINCLAIR] FR The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.

[HUANG, Wei, MANTELL, Simon John, STRANG, Ross Sinclair, THORARENSEN, Atli, TRUJILLO, John Isidro, TURNER, Steve Ronald, YEAP, Siew Kuen] Pfizer Global Research and Development Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Global Research and Development 700 Chesterfield Parkway Chesterfield, Missouri 63017;Pfizer Global Research and Development Ramsgate Road Sandwich Kent CT13 9NJ;c/o Pfizer Global Research and Development Ramsgate Road Sandwich Kent CT13 9NJ;Pfizer Global Research and Development 700 Chesterfield Parkway Chesterfield, Missouri 63017;Pfizer Global Research and Development 700 Chesterfield Parkway Chesterfield, Missouri 63017;Pfizer Global Research and Development 700 Chesterfield Parkway Chesterfield, Missouri 63017;Pfizer Global Research and Development Ramsgate Road Sandwich Kent CT13 9NJ The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allergic and respiratory conditions.

[Graham Lunn, John Paul Mathias, Ross Sinclair Strang] GB Canterbury The present invention relates to tetrahydronaphthyridine derivatives of the general formula (I):or of the general formula (I′)in which A and R1 are as defined within, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, including the treatment diseases mediated by H3 ligands, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.