[BUCKLEY, Naomi, CLARK, Benjamin, J., CUMMINS, Michael, DONOVAN, Danny, GELFAND, Mark, HUGHES, Luke, KELLY, Brian, KELLY, Gary, KELLY, Grace, KELLY, John, LEDWITH, Seamus, LEUNG, Mark, S., MCMULLIN, Gwenda, MULLINS, Barry, NAGA, Karun, D., NASH, Stephen, PICCAGLI, Francesco, RYBA, Eric, SWEENEY, Fiachra, TILOTTA, Vicenzo, TUROVSKIY, Roman, WOOLLEY, Lana, ZARINS, Denise] 62 Caiseal Cam Roscam, Galway City Galway;1380 Shorebird Way Mountain View, CA 94043;251 Roscaoin Roscam, Galway;C/o 21 Coill Tire Galway, Doughiska;304 8th Avenue, Apt. 3 New York, NY 10001;Crannagh Cort Galway;C/o Moyvilla Oranmore Galway, Ballybrit;Dooras Cornamona Galway;Winnowing Hill, Balconey Road Clifden, Galway;Derrymullen Ballinsloe, Galway;Corbally, Cummer, Tuam Galway;2348 Larsen Road Shawnigan Lake, BC V0R 2W1;Parkmore Business Park West Ballybrit, Galway;Fairhaven Delgany Wicklow;4382 Headen Way Santa Clara, CA 95054;Churchtown, Newcastle West Galway;Via Martiri Della Liberta' 7 I-BS 25030 Roncadelle;1380 Shorebird Way Mountain View, CA 94043;9 Semple Mill, Parkavera Galway;Parkmore Business Park West Ballybrit Galway;240 N. Lake Merced Hill San Francisco, California 94132;Parkmore Business Park West Galway Ballybrit;20746 Verde Vista Lane Saratoga, CA 95070 Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

[LEUNG, Mark S., CLARK, Benjamin J., MICHLITSCH, Kenneth, THAI, Erik, WU, Andrew, ZARINS, Denise] 102 rue des Maraichers L-2124 Luxembourg;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403;c/o Medtronic Vascular 3576 Unocal Place Santa Rosa, CA 95403 Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

[Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins] US CA Palo Alto Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

[BUCKLEY, Naomi, CLARK, Benjamin J., CUMMINS, Michael, DONOVAN, Danny, GELFAND, Mark, HUGHES, Luke, KELLY, Brian, KELLY, Gary, KELLY, Grace, KELLY, John, LEUNG, Mark S., McMULLIN, Gwenda, MULLINS, Barry, NAGA, Karun D., NAASH, Stephen, RYBA, Eric, SWEENEY, Fiachra, TILOTTA, Vincenzo, WOOLLEY, Lana, ZARINS, Denise] 62 Caiseal Cam Roscam, Galway City, Galway, IE

[BUCKLEY NAOMI, CLARK BENJAMIN, CUMMINS MICHAEL, DONOVAN DANNY, GELFAND MARK, HUGHES LUKE, KELLY BRIAN, KELLY GARY, KELLY GRACE, KELLY JOHN, LEUNG MARK, MCMULLIN GWENDA, MULLINS BARRY, NAGA KARUN D, NASH STEPHEN, RYBA ERIC, SWEENEY FIACHRA, TILOTTA VINCENZO, WOOLLEY LANA, ZARINS DENISE] IE;US;IE;IE;US;IE;IE;IE;IE;IE;CA;IE;IE;US;IE;US;IE;IE;IE;US Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state. 100\ Figs. 2A & 2B 108- 113 115

[Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai] US CA Foster City Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

[BUCKLEY, Naomi, CLARK, Benjamin, J., CUMMINS, Michael, DONOVAN, Danny, GELFAND, Mark, HUGHES, Luke, KELLY, Brian, KELLY, Gary, KELLY, Grace, KELLY, John, LEUNG, Mark, S., MCMULLIN, Gwenda, MULLINS, Barry, NAGA, Karun, D., NASH, Stephen, RYBA, Eric, SWEENEY, Fiachra, TILOTTA, Vicenzo, TUROVSKIY, Roman, WOOLLEY, Lana, ZARINS, Denise, TUROVSKIY, Michael] 62 Caiseal Cam Roscam, Galway City Galway;1380 Shorebird Way Mountain View, CA 94043;251 Roscaoin Roscam, Galway;C/o 21 Coill Tire Galway, Doughiska;304 8th Avenue, Apt. 3 New York, NY 10001;Crannagh Cort Galway;C/o Moyvilla Oranmore Galway, Ballybrit;Dooras Cornamona Galway;Winnowing Hill, Balconey Road Clifden, Galway;Derrymullen Ballinsloe, Galway;2348 Larsen Road Shawnigan Lake, British Columbia, V0R 2W1;Parkmore Business Park West Ballybrit, Galway;Fairhaven Delgany Wicklow;4382 Headen Way Santa Clara, CA 95054;Churchtown, Newcastle West Galway;1380 Shorebird Way Mountain View, CA 94043;9 Semple Mill, Parkavera Galway;Parkmore Business Park West Ballybrit Galway;240 N. Lake Merced Hill San Francisco, CA 94132;Parkmore Business Park West Galway, Ballybrit;20746 Verde Vista Lane Saratoga, CA 95070;240 N. Lake Merced Hills San Francisco, CA 94132 Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

[WU, Andrew, CLARK, Benjamin, J., ZARINS, Denise, THAI, Erik] 1380 Shorebird Way Mountain View, California 94043;506 Gibraltor Lane Foster City, CA 94404;498 Alameda De Las Pulgas Redwood City, CA 94062;20746 Verde Vista Lane Saratoga, CA 95070;2318 Brushgen Way San Jose, CA Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

[Denise Zarins, Andrew Wu, Hanson Gifford, III, Mark Deem, Mark Gelfand, Howard R. Levin] US CA Saratoga Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

[MAUCH, Kevin, ALVARADO, Mario, BEETEL, Robert, J., COLE, Juanita, Sanchez, CHANG, William, GOSHGARIAN, Justin, RIVERA, Leonila, SHIN, Sukyoung, SILVER, Michele, SOM, Sina, WU, Andrew, ZARINS, Denise, ABOYTES, Maria, G.] 102 rue des Maraichers Luxembourg, Luxembourg L2124;9463 Victoria Lane Windsor, CA 95492;3576 Unocal Place Santa Rosa, CA 95403;1380 Shorebird Way Mountain View, CA 94043;2320 Vennie Court Santa Rosa, CA 95401;5772 Trailwood Drive Santa Rosa, CA 95404;4340 Leafwood Circle Santa Rosa, CA 95405;942 Dorothea Court Windsor, CA 95492;5726 Raters Drive Santa Rosa, CA 95409;258 Usher Drive Windsor, CA 95492;2124 Francisco Avenue San Francisco, CA 95403;1380 Shorebird Way Mountain View, CA 94043;20746 Verde Vista Lane Saratoga, CA 95070;915 Colorado Ave. Palo Alto, CA 94303 Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfused the neural fibers.